Fungal and yeast genetics research

This study identifies Row1 as a conserved fungal protein essential for appressoria function in Ustilago maydis, showing its role in cell wall modification and secretion during plant infection.

This study identifies two enzymes, Glg1 and Goe1, that link glycogen synthesis to cell wall glucan formation in Cryptococcus neoformans.

This study identifies greater sequence variation in non-coding regions of A. fumigatus genes compared to protein-coding regions, suggesting a role in phenotypic differences between strains.

This study identifies dual localization of mitochondrial carrier proteins Aac2 and Mir1 to peroxisomes and mitochondria in Hansenula polymorpha, revealing requirements for Pex3 and Pex19 in peroxisomal targeting.

This study maps the phosphorylation landscape of the rice blast fungus during infection, identifying key phosphoproteins and pathways involved in disease progression.

This paper uses proteomics to show that Prn1 in Candida albicans is critical for oxidative stress response, affecting protein abundance, survival, and apoptosis.

This study uses machine learning to analyze yeast genomes and growth data to uncover how diet influences the evolution of galactose metabolism.

This study identifies novel -(1->6)-linked mannan structures in Aspergillus fumigatus mycelium and characterizes the enzymes involved in their biosynthesis.

This study investigates the regulatory network of the White Collar complex in Schizophyllum commune during early mushroom development, showing light-dependent promoter binding and transcriptional activation.

The paper demonstrates the use of L-SCRaMbLE to generate large-scale genome rearrangements in synthetic Sc2.0 yeast chromosomes through light-inducible Cre recombinase.

This paper develops a biosensor to visualize and manipulate PKA activity in fission yeast, revealing its dynamics during cell cycle phases.

This study demonstrates the use of alkaline-pH regulatable promoters for methanol-free expression of phytase in Komagataella phaffii, achieving higher production than the traditional AOX1 promoter.

The paper identifies new alleles and regulatory mechanisms of the fMAPK pathway in yeast through genetic screening and whole-genome sequencing.

This study investigates how budding yeast adapts to sucrose transitions by analyzing cAMP signaling dynamics and their impact on growth and metabolism.

This paper compares the temporal dynamics of morphogenesis and gene expression during C. albicans filamentation in vitro and in vivo, identifying key differences in metabolic gene expression and hyphae-to-yeast transition rates.

This paper investigates the role of H3K4 methylation in Mucorales fungi, showing it regulates development, DNA repair, and virulence through genetic and phenotypic analyses of set1 knockout strains.

The paper expands a yeast cloning toolkit to include optimized signal peptides and surface display anchors for improved protein secretion and display in S. cerevisiae.

The paper genetically modifies Candida maltosa to study Efg1 function, finding it represses filamentation despite gene loss in the species.

The paper identifies Ppg1 as a phosphatase that regulates Far complex assembly to maintain gluconeogenic outputs during glucose depletion in yeast.

The paper analyzes PKA signaling in yeast using phosphoproteomics to show how different cAMP concentrations and conditions affect phosphorylation thresholds and growth states.

This study identifies signal-specific MoYpd1 isoforms in Magnaporthe oryzae that are essential for virulence, showing their distinct roles in stress response and pathogenicity.

This paper develops a yeast artificial chromosome system in K. marxianus to enhance heterologous protein expression by incorporating disulfide bond formation modules, achieving record-high glucoamylase yields.

The paper presents a telomere-to-telomere genome assembly of S. japonicus, revealing a previously unknown second centromere-like region and revising the genome size estimate.

The paper shows that the fungal gene ENB1, acquired from a bacterial operon, enables iron uptake in W/S clade yeasts and evolved through horizontal transfer and gene loss.

This study visualizes and analyzes the spatial and temporal dynamics of glaA mRNA in Aspergillus oryzae, revealing its localization near hyphal tips and septa and its dependence on microtubule motors.

This study investigates how manganese homeostasis affects virulence and stress tolerance in Candida albicans through transcriptional profiling and genetic analysis.

The paper shows Elm1 and Gin4 kinases regulate each other through direct binding and phosphorylation to control septin hourglass assembly and remodeling during different cell cycle stages in yeast.

The paper identifies 829 xenologs in 44 early diverging fungi, revealing patterns of horizontal gene transfer and its impact on fungal metabolism, adaptation, and immunity.

This study shows that the function of the C. albicans transcriptional repressor NRG1 varies by strain, affecting filamentation and virulence in different contexts.

The paper identifies a novel gene family, Snowball (snb), essential for fruiting body development in Agaricomycetes fungi, showing its role in differentiation through mutant analysis and transcriptomics.