Vestibular and auditory disorders

Dynamic arm movements attenuate perceptual distortion of visual vertical induced during prolonged whole-body tilt

The paper investigates how dynamic arm movements during whole-body tilt affect perceptual distortion of visual vertical, finding reduced distortion during tilt but not after.

A neuroanatomically grounded optimal control model of the compensatory eye movement system

The paper develops an optimal control model of the compensatory eye movement system that successfully reproduces eye movement data across multiple conditions and explains non-linear reflex summation.

A Bayesian Generative Model of Vestibular Afferent Neuron Spiking

The paper develops a Bayesian generative model of vestibular afferent neuron spiking and shows it accurately captures spike train data with three parameters.

Ocular vestibular evoked myogenic potential (VEMP) reveals subcortical HTLV-1-associated neurological disease

The paper compares cervical and ocular VEMP in HTLV-1-infected individuals with and without myelopathy to assess subcortical neurological impairment.

Recruitment orders underlying binocular coordination of eye position and velocity in the larval zebrafish hindbrain

The paper identifies and characterizes oculomotor neurons in the zebrafish hindbrain, revealing a mixed binocular code with position and velocity tuning.

Rare Variants in the OTOG Gene Are a Frequent Cause of Familial Meniere’s Disease

The paper identifies rare variants in the OTOG gene as a frequent cause of familial Meniere’s disease through exome sequencing and variant analysis.

Cytochrome P450 26b1-mediated specification of vestibular striola and central zones is required for transient responses in linear acceleration

This study shows that Cyp26b1-mediated RA degradation during embryogenesis is essential for patterning vestibular zones, which are critical for transient responses to linear acceleration.

Quantitative assessment of anti-gravity reflexes to evaluate vestibular dysfunction in rats

This study quantifies anti-gravity reflexes in rats to assess vestibular dysfunction using acute and sub-chronic IDPN exposure, showing dose- and time-dependent impairments.

Simple spike dynamics of Purkinje cells in the macaque vestibulo-cerebellum reflect sensory prediction error

The paper examines Purkinje cell dynamics in the macaque vestibulo-cerebellum, finding that two cell types encode tilt velocity and translation acceleration, which represent sensory prediction error for updating sensory estimates.

Selective targeting of unipolar brush cell subtypes by cerebellar mossy fibers

The paper shows that primary afferents selectively connect to ON unipolar brush cells, while secondary afferents connect to both ON and OFF subtypes, revealing distinct anatomical pathways for signal transformation.

Shared neural mechanisms between imagined and perceived egocentric motion - A combined GVS and fMRI study

This study investigates shared neural mechanisms between imagined and perceived egocentric motion using GVS and fMRI, finding overlap in brain areas involved in vestibular processing and mental rotation.

Spike burst-pause dynamics of Purkinje cells regulate sensorimotor adaptation

This paper uses a spiking cerebellar model to show how Purkinje cell burst-pause dynamics regulate vestibular ocular reflex adaptation and learning.

Excess of rare missense variants in hearing loss genes in sporadic Meniere disease

This study identifies an excess of rare missense variants in SNHL genes in sporadic Meniere disease patients compared to controls.

Whole-brain calcium imaging during physiological vestibular stimulation in larval zebrafish

This paper develops a light-sheet microscope to enable whole-brain calcium imaging in head-restrained zebrafish during vestibular stimulation, revealing dynamic brain responses to physiological inputs.

Cellular resolution imaging of vestibular processing across the larval zebrafish brain

The paper uses fictive vestibular stimulation and whole-brain calcium imaging to map vestibular-responsive neurons in larval zebrafish, revealing widespread and diverse cellular responses.

Neuronal thresholds and correlations in the peripheral vestibular system during rotation discrimination

This study measures neuronal and behavioral thresholds during rotation discrimination in macaques, finding similar thresholds and significant neuronal correlations but no trial-by-trial activity-behavior link.

Beyond the vestibulo-ocular reflex: Vestibular input is processed centrally to achieve visual stability

The paper re-analyzes data from Zink et al. to show that vestibular input is processed centrally to stabilize vision when ocular torsion is insufficient.

A unified internal model theory to resolve the paradox of active versus passive self-motion sensation

The paper constructs a Kalman filter model to explain how a single internal model of head motion processes motor commands and sensory signals during both active and passive movements.

Gaze-stabilizing central vestibular neurons project asymmetrically to extraocular motoneuron pools

The paper identifies asymmetric projections of central vestibular neurons in zebrafish and shows how these projections enhance sensory encoding of nose-up stimuli while maintaining gaze stabilization.

Cerebellar Re-Encoding Of Self-Generated Head Movements

The paper shows that caudal cerebellar vermis cells re-encode head movements into a gravity-polarized representation.