Vestibular and auditory disorders

Vestibular control of posture deviates from Weber's law in response to electrical vestibular stimulation

This study shows that vestibular control of posture does not follow Weber's law, with balance discrimination thresholds increasing sublinearly with stimulus amplitude.

Repeated Inertial Stimulation Reveals Divergent Plasticity in Peripheral and Central Vestibular Pathways

This study investigates how different jerk characteristics affect peripheral and central vestibular pathways in rats, revealing distinct plasticity patterns in their responses to mechanical vestibular load.

Disruption of a Structural Niche for Otoconia Maintenance May Underlie Common Vestibular Disorders

The paper identifies a structural niche in the inner ear responsible for otoconia maintenance and links its disruption to vestibular disorders.

Causal mapping of self-motion networks in the human brain

This study uses invasive brain stimulation to identify cortical regions and networks involved in vestibular self-motion perception in humans.

GWAS and multimodal transcriptomic profiling of human otolithic organs characterize the genetic architecture of balance in the elderly

The paper identifies genetic factors associated with balance in the elderly through GWAS and multimodal transcriptomic analysis of otolithic organs.

Functional maturation in abducens motoneurons populations during angular VOR larval development

This study examines the maturation of Abducens motoneurons during larval development, showing increased discharge modulation in silent units and enhanced myelination in late larval stages.

VESTIBULAR FUNCTION LOSS ASSOCIATES WITH SENSORY EPITHELIUM PATHOLOGY IN VESTIBULAR SCHWANNOMA PATIENTS

This study links vestibular function loss in vestibular schwannoma patients to sensory epithelium pathology, including reduced hair cell counts and calyx damage.

Differential maturation in vestibular neuronal groups related to developmental motor reorganization in amphibians

The paper investigates how vestibular neuronal maturation changes during amphibian metamorphosis, showing a shift from tonic to phasic discharge in vestibulospinal neurons.

Cortical vestibular-evoked potentials depend on body orientation

The paper investigates how body orientation affects cortical vestibular-evoked potentials (vEPs) and identifies Na/Pa and N*/P* as markers of otolithic processing.

Genome-wide analysis implicates inner ear development in Meniere's disease

This study identifies genetic loci associated with Meniere's disease and links them to inner ear development and retinoic acid metabolism.

A Mechanosensitive GPCR at vestibular kinocilium is required for normal balance

This study identifies mGlu2 as a mechanosensitive GPCR in vestibular hair cells essential for balance, distinct from its role in hearing.

Graded Hair Cell Ablation Reveals Functional Redundancy in the Mature Mouse Vestibular System

This study shows that the adult mouse vestibular system maintains functional responses despite significant hair cell loss, with different levels of redundancy in macula and crista ampullaris.

Deciphering the role of brainstem vestibular-related inhibitory networks in shaping postural reflexes in the Xenopus tadpole

The paper identifies inhibitory vestibular neurons in Xenopus tadpoles and shows they modulate postural reflexes through interactions with excitatory vestibulospinal neurons.

MDAtlas: A Multiomics Meniere Disease Database of Genes and Cells

MDAtlas provides an open-access multiomics database for Meniere Disease, integrating genomic, transcriptomic, and epigenomic data to support research on disease mechanisms and biomarkers.

Minimizing the influence of magnetic vestibular stimulation inside MRI-scanners by adjusting head position

This study identifies head positions in MRI scanners that minimize magnetic vestibular stimulation effects by eliminating vestibulo-ocular reflex components through specific pitch and roll angles.

Rare Missense Variants in MYO7A and OTOP2 Genes in a South Korean Meniere Disease Cohort

The paper identifies rare missense variants in OTOP2 and MYO7A genes in a South Korean Meniere disease cohort, suggesting their potential pathogenic roles.

Replication of missense OTOG gene variants in a Brazilian cohort of Meniere's Disease

The paper reports rare missense OTOG variants in a Brazilian MD patient, suggesting their potential role in MD pathophysiology through structural destabilization of Otogelin.

Dynamics of thalamic directional coding under vestibular imbalance

This study investigates how head direction cells adapt to unilateral vestibular loss in rats, revealing cell-type-specific changes in directional coding.

A novel membrane contact site in vestibular hair cells

The paper describes a novel membrane contact site in mouse type I vestibular hair cells associated with atypical plasma membrane-apposed mitochondria, potentially modulating non-quantal transmission.

Circuit mechanisms to transform neural population dynamics for motor control

The paper identifies input-output transformations in the cerebellar circuit and shows how interneurons and plasticity enable flexible motor control.

KV1.8 (Kcna10) potassium channels enhance fast, linear signaling in vestibular hair cells and facilitate vestibulomotor reflexes and balance

This study shows that KV1.8 potassium channels in vestibular hair cells enhance fast signaling and support balance and motor reflexes by improving response time, gain, and frequency range.

Wavelet transform of single-trial vestibular short-latency evoked potential reveals temporary reduction in signal detectability and temporal precision following noise exposure

The paper applies wavelet transform to single-trial VsEP data to quantify noise-induced changes in signal detectability and temporal precision in rats.

A brainstem circuit for gravity-guided vertical navigation

This study identifies a brainstem circuit in larval zebrafish that converts gravitational signals into vertical navigation by maintaining consistent heading.

PP2B-dependent cerebellar plasticity sets the amplitude of an innate reflex during juvenile development

This study shows that early disruption of cerebellar plasticity affects the setpoint of the vestibulo-ocular reflex (VOR), while adult-onset disruption only impacts its adaptation.

Using Manganese Enhanced Magnetic Resonance Imaging (MEMRI) to Assess Calcium Dependent Activity in Vestibular Pathways Following Linear Acceleration

This study uses MEMRI to assess calcium-dependent activity in vestibular pathways of rats after linear acceleration, showing differential Mn2+ uptake in specific brain regions.

Noise-induced changes in rat head stability and orientation correlate with dysfunction of otolith irregular afferents

This study shows that noise exposure reduces CR+ calyces and alters head stability and orientation in rats, correlating with changes in VsEP amplitudes and behavioral responses.

Elucidating the role of muscarinic acetylcholine receptor (mAChR) signaling in efferent mediated responses of vestibular afferents in mammals

This study identifies M3 mAChRs as mediators of efferent-mediated slow excitation in irregular vestibular afferents and suggests M1 mAChRs may drive similar effects in regular afferents.

Evidence that ultrafast non-quantal transmission underlies short-latency vestibular evoked potentials.

The paper demonstrates that ultrafast non-quantal transmission underlies short-latency vestibular evoked potentials in guinea pigs.

Subchronic alteration of vestibular hair cells in mice: implications for multisensory gaze stabilization

This study investigates subchronic vestibular hair cell damage in mice, showing partial loss affects VOR and OKR, with reduced visuo-vestibular integration despite VOR recovery.

Vestibular Compound Action Potentials and Macular Velocity Evoked by Sound and Vibration in the Guinea Pig.

This study investigates how transient sounds and vibrations activate vestibular afferents in guinea pigs by measuring mechanical and neural responses.