Vestibular and auditory disorders

Brain inputs to the vestibular nuclei in lampreys

This study investigates brain inputs to the vestibular nuclei in lampreys, finding sparse connections from other brain regions and extensive interconnections within the vestibular nuclei.

When Noise Isnt Simply Noise: Deterministic Postural Drive During Noisy Galvanic Vestibular Stimulation (nGVS)

This study shows low-amplitude nGVS can influence postural behavior through deterministic effects, not just stochastic resonance, by analyzing coherence and time-cumulant density in response to galvanic vestibular stimulation.

Deficits in tail-lift and air-righting reflexes in rats after ototoxicity associate with loss of vestibular type I hair cells

This study shows that ototoxicity in rats causes loss of vestibular type I hair cells, which correlates with deficits in tail-lift and air-righting reflexes, with different dependencies on specific regions.

Directionally Biased Neuronal Responses to Pitch-Axis Vestibular Stimulation in Larval Zebrafish Compared to Roll-Axis Responses

The paper maps zebrafish brain responses to pitch and roll-axis vestibular stimulation, revealing directional biases in neuronal activity and identifying specific brain regions involved in motion perception.

Functional contributions of quantal and non-quantal hair cell synaptic transmission in the vestibular periphery

This study investigates the functional roles of quantal and non-quantal synaptic transmission from type I and II hair cells in mice, showing that non-quantal transmission can drive vestibular responses across a wide range of frequencies, while quantal transmission is essential for gravity detection.

Head stabilization behavior and underlying circuit mechanisms in larval zebrafish

This study shows larval zebrafish use a VCR-like behavior for head stabilization through specific body flexions and neural circuits, similar to mammals.

Explaining attractive and repulsive biases in the subjective visual vertical

The paper explains both attractive and repulsive biases in the subjective visual vertical using a Bayesian model, resolving a long-standing question in perceptual psychology.

Bat eye movements resolve a long-standing question in gaze control

This study quantifies eye movements in bats, showing robust visual and otolith-driven gaze stabilization, challenging the assumption that bats lack eye movement.

Persistence of vestibular function in the absence of glutamatergic transmission from hair cells

This study shows that vestibular function remains normal in Vglut3-/- mice despite severe reduction in glutamatergic synaptic transmission, suggesting non-quantal transmission compensates for the loss.

Selective genetic targeting of the mouse efferent vestibular nucleus identifies monosynaptic inputs and indicates function as multimodal integrator

The paper develops a method to selectively target efferent vestibular neurons in mice to map their monosynaptic inputs and demonstrate their role as a multimodal integrator.

Hair cell population integrity necessary to preserve vestibular function

The paper investigates the relationship between hair cell integrity and vestibular function, finding that 50% of hair cells are needed for minimal function and 80% for normal function.

Vertical Optokinetic Eye Movements in the Larval Zebrafish

This study characterizes the vertical optokinetic response in larval zebrafish, revealing differences from horizontal OKR and insights into visual processing and eye movement control.

Does stimulus order affect central tendency and serial dependence in vestibular path integration?

This study investigates whether stimulus autocorrelation affects central tendency and serial dependence in vestibular path integration, finding these biases persist regardless of sequence protocol.

Hyperplastic Growth, Not Hydrostatic Distension, in Endolymphatic Hydrops in Humans Challenges the Classic View of Meniere's Disease

This study challenges the traditional view of Meniere's disease by showing that endolymphatic hydrops is associated with epithelial hyperplasia rather than fluid pressure, suggesting a compensatory cellular response.

Galvanic vestibular stimulation alters the sense of upright

This study investigates how galvanic vestibular stimulation (GVS) affects the perception of upright body orientation, finding that right-sided anodal GVS alters the Subjective Postural Vertical (SPV) in both young and older adults.

Different contribution of missense and loss-of-function variants to the genetic structure of familial and sporadic Meniere disease

This study compares the genetic burden of missense and loss-of-function variants in familial and sporadic Meniere disease, finding divergent genetic architectures and shared enriched genes.

An integrated system for comprehensive mouse peripheral vestibular function evaluation based on Vestibulo-ocular Reflex

This paper develops an integrated system for evaluating mouse vestibular function using VOR tests and validates it with multiple peripheral vestibular models.

Cerebellum involvement in visuo-vestibular interaction for the perception of gravitational direction: a repetitive transcranial magnetic stimulation study

This study uses rTMS to show cerebellar vermis involvement in visuo-vestibular integration for gravitational direction perception, reducing visual dependency in OKS-induced SVV bias.

Visual and vestibular reweighting after cyber- and space-sickness

This study examines how visual and vestibular reweighting occurs after exposure to different sensory conflict paradigms and finds that sensitivity to the stimulated modality determines susceptibility to motion sickness.

Stimulation of otolith irregular fibers produces a rostro-caudal gradient in activity in the vestibular nuclear complex (VNC), but not the vestibulocerebellum (VeCb)

This study maps neuronal activity in the vestibular nuclear complex and vestibulocerebellum after otolith irregular fiber stimulation, showing a rostro-caudal gradient in the VNC but not the VeCb.

Anatomical and functional studies of isolated vestibular neuroepithelia from Meniere's Disease patients

This study examines vestibular neuroepithelium from Meniere's Disease patients, showing surviving hair cells maintain normal voltage-activated currents despite significant loss and disorganization.

Reference frames for encoding of translation and tilt in the caudal cerebellar vermis

The paper investigates how neurons in the caudal cerebellar vermis encode translation and tilt by analyzing their response to changes in head-re-body and body-re-gravity orientation.

Sensation is Dispensable for the Maturation of the Vestibulo-ocular Reflex

The paper shows that sensory experience is not required for the maturation of the vestibulo-ocular reflex in larval zebrafish, as neuromuscular junction development drives reflex maturation.

Balance performance in aged mice is dependent on unipolar brush cells

This study shows that unipolar brush cells (UBCs) are essential for balance in aged mice, as disrupting their activity impairs balance performance and vestibular-related behaviors in older mice but not young mice.

Vestibular afferent neurons develop normally in the absence of quantal/glutamatergic input

This study shows that vestibular ganglion neurons develop normal biophysical diversity without glutamatergic input, but with subtle differences in large cells.

Transiently Worse Postural Effects After Vestibulo-ocular Reflex Gain-Down Adaptation in Healthy Adults

This study shows that after simulating unilateral vestibular hypofunction, body sway increases temporarily but returns to normal, suggesting dynamic sensory reweighting.

Central tendency and serial dependence in vestibular path integration

The paper investigates central tendency and serial dependence biases in vestibular path integration using a distance reproduction task in darkness, finding similar biases to those observed in visual path integration.

Vestibular prepulse inhibition of the human blink reflex

This study investigates the effect of a vestibular prepulse on the blink reflex in humans, finding inhibition in healthy subjects but not in those with vestibular failure.

Sustained bias of spatial attention in a 3T MRI scanner

This study examines the time course and aftereffects of MVS-induced spatial attention bias and VOR in a 3T MRI scanner, showing sustained attention bias and temporary aftereffects.

RPM: an open-source rotation platform for open- and closed-loop vestibular stimulation in head-fixed mice

The paper introduces an open-source rotation platform for vestibular stimulation in head-fixed mice, enabling both open- and closed-loop experiments to study spatial navigation.