Prostate Cancer Treatment and Research

Transcriptional mediators of treatment resistance in lethal prostate cancer

This study identifies transcriptional states in mCRPC that mediate treatment resistance, including AR splicing heterogeneity, TGF-β signaling, and immune infiltration patterns.

Mapping Isoform Abundance and Interactome of the Endogenous TMPRSS2-ERG Fusion Protein with Orthogonal Immunoprecipitation-Mass Spectrometry Assays

The paper quantifies the abundance and interactome of the TMPRSS2-ERG fusion protein in prostate cancer cells using IP-MS assays, identifying key isoforms and interaction partners.

RUNX1 marks a luminal castration resistant lineage established at the onset of prostate development

This study identifies RUNX1 as a marker for a castration-resistant luminal lineage in the developing and adult mouse prostate, distinct from NKX3.1+ cells.

A single-cell atlas of the mouse and human prostate reveals heterogeneity and conservation of epithelial progenitors

This study creates a single-cell atlas of mouse and human prostate epithelium, identifying conserved progenitor populations and anatomical relationships between species.

Development and validation of a six-RNA binding proteins prognostic signature and candidate drugs for prostate cancer

The paper identifies a six-RNA binding protein prognostic signature and three candidate drugs for prostate cancer using TCGA data and Connectivity Map.

Identification of potential biomarkers associated with pathogenesis of primary prostate cancer based on meta-analysis approaches

This study identifies potential biomarkers for primary prostate cancer through meta-analysis of transcriptomic data and functional enrichment analysis.

Patient-matched analysis identifies deregulated networks in prostate cancer to guide personalized therapeutic intervention

The paper identifies patient-specific deregulated regulatory networks in prostate cancer to inform personalized therapeutic strategies.

SCAND1 suppresses CDC37 gene transcription by repressing MZF1

The paper identifies SCAND1 as a tumor suppressor that negatively regulates CDC37 gene transcription by inhibiting MZF1 in prostate cancer.

Identification of a basal stem cell subpopulation in the prostate via functional, lineage tracing and single-cell RNA-seq analyses

The paper identifies a basal stem cell subpopulation in the prostate using lineage tracing, functional analysis, and single-cell RNA-seq, showing Zeb1+ cells are multipotent prostate basal stem cells.

Metabolic deregulation in prostate cancer

The paper identifies six metabolic subgroups of prostate cancer using transcriptomics data, showing distinct survival outcomes and highlighting metabolic pathways as potential early diagnostic indicators.

A community-based collaboration to build prediction models for short-term discontinuation of docetaxel in metastatic castration-resistant prostate cancer

This paper presents a crowdsourced challenge to predict early discontinuation of docetaxel in mCRPC patients using clinical data from multiple trials, finding that ensemble models outperform individual models.