Hypothalamic control of reproductive hormones

The paper examines changes in pituitary function in a mouse model of chronic temporal lobe epilepsy, finding increased GnRH sensitivity and gene expression in females but no significant changes in LH or FSH levels.

The paper identifies a gene regulatory network in Atlantic salmon linking vgll3 to regulators of sexual maturation, suggesting alternative mechanisms to GnRH1 in controlling c-jun and sf1 expression.

The paper investigates how kisspeptin neurons in the medial amygdala modulate GnRH pulse frequency through GABA and glutamate neurotransmission in female mice.

The paper creates a comprehensive neuroanatomical atlas of glycoprotein hormone receptor expression in the brain using single-transcript detection technologies.

The paper investigates the association between urinary kisspeptin concentrations and pubertal development in children, finding sex-specific differences and potential for non-invasive assessment.

The paper investigates GABA transmission to GnRH neurons in an epilepsy mouse model, finding sex-specific changes linked to estrous cycle disruption.

The paper investigates whether GnRH neuron firing in female mice with epilepsy correlates with seizure severity and finds no such relationship.

This study shows that psychosocial stress delays puberty and increases anxiety in female mice by affecting Urocortin3 neurons in the medial amygdala.

This study shows that maternal immune activation accelerates puberty and alters pain sensitivity in mice, with environmental enrichment mitigating some effects.

The paper uses in vivo calcium imaging to show KNDy neurons synchronize in a temporal order before LH pulses, revealing a structured activation pattern in the GnRH pulse generator.

The paper investigates how glutamatergic transmission modulates GnRH pulsatility in the arcuate kisspeptin network across the estrous cycle using optogenetics and mathematical modeling.

This study identifies a recessive PRDM13 mutation causing congenital hypogonadotropic hypogonadism and cerebellar hypoplasia through mouse models and human expression analysis.

This study investigates whether prenatal androgen treatment affects the firing activity of hypothalamic arcuate kisspeptin neurons in female mice, finding no significant differences in firing rates across age groups.

The paper investigates the role of GFAP-expressing astrocytes in regulating GnRH and KNDy neuron activity and LH release, finding that Gq signaling in the preoptic area increases LH release and GnRH firing.

This study investigates sex differences in GnRH neuron potassium currents and excitability under homeostatic feedback conditions, finding no significant differences between sexes.

The paper examines how progesterone receptor expressing neurons in the VMHvl change structurally and electrophysiologically along the anterior-posterior axis and across the reproductive cycle.

The paper shows that EED represses Kdm6b, increasing H3K27me3 and reducing gene expression in a puberty-activating network.

The paper shows that kisspeptin, not other co-transmitters, activates GnRH neuron dendrons, and that its deletion abolishes episodic hormone secretion despite preserved KNDy neuron synchronization.

The paper identifies two spexin paralogs in tilapia that inhibit FSH and LH via Galr2b, revealing their role in the brain-pituitary-gonad axis.

The paper shows that optogenetic stimulation of MePD kisspeptin neurons in female mice increases LH pulse frequency, suggesting their role in regulating the GnRH pulse generator.

This study shows Gli3 is critical for olfactory ensheathing cell development and GnRH-1 neuronal migration, and identifies a GLI3 mutation in a Kallmann syndrome patient.

This study uses CRISPR-Cas9 to disrupt ER in specific kisspeptin neuron populations in adult mice, revealing distinct roles of AVPV and arcuate kisspeptin neurons in estradiol-mediated negative and positive feedback on GnRH.

This study shows that NKB signaling in the medial amygdala stimulates gonadotropin release in female mice independently of kisspeptin.

This study identifies miR-505-3p as a repressor of puberty onset in female mice, showing delayed puberty and reduced fertility with its overexpression and earlier puberty with its knockout.

This study identifies PACAP-expressing neurons in the ventral premammillary nucleus that regulate reproductive function in female mice by modulating kisspeptin neurons.

This study identifies 26 genetic loci associated with reproductive ageing in a Japanese population, highlighting differences in allele frequencies and effect estimates compared to European populations.

The paper estimates genetic and environmental influences on testosterone, DHEA, and progesterone concentrations in human hair across 8-18 years in twins, identifying sex-specific heritability peaks.

The paper investigates how stress affects the HPG axis transcriptome in rock doves, finding females show more differential gene expression than males.

This study identifies sex-biased gene expression patterns in the HPG axis of rock doves, revealing tissue-specific differences in reproductive-related genes.

This study shows that proper olfactory bulb development and olfactory/vomeronasal axonal connections are not required for GnRH-1 neuronal migration to the hypothalamus.