Hypothalamic control of reproductive hormones

Kiss1 neurons in the medial amygdala of mice are sexually dimorphic and unique from hypothalamic anteroventral periventricular Kiss1 neurons in their action potential firing properties

The paper examines the electrophysiological properties of Kiss1 neurons in the medial amygdala (MeA) of mice, finding sexual dimorphism and distinct firing characteristics compared to hypothalamic Kiss1 neurons.

A brain locus for viable gestation

This study identifies a brain-specific neuronal population critical for viable pregnancy by analyzing gene expression changes in estrogen receptor alpha-expressing neurons during gestation.

Differentiation of KISS1-Expressing Cells from Human Pluripotent Stem Cells: Many Roads To Rome

This study differentiates human pluripotent stem cells into KISS1-expressing neuron cultures using two distinct protocols and identifies marker gene expression differences between the resulting cell types.

Hypothermic Conditions Impair GnRH Pulse Generator Activity and Gametogenesis

This study shows hypothermia, not hypometabolism, suppresses reproductive activity in mice by reducing arcuate kisspeptin neuron activity during energy-saving conditions.

Endocrine-Adapted Pituitary Macrophages Regulate Gonadotropin Secretion through CXCL5-CXCR2-MAPK Signaling

The paper identifies pituitary macrophages as hormone-producing immune cells that regulate gonadotropin secretion through CXCL5-CXCR2-MAPK signaling in female mice.

Evolutionary trade-offs between growth and reproduction under obesogenic conditions: sex-biased skeletal and gonadal maturation in mice

This study shows that high-fat diets during adolescence shift energy allocation in mice toward reproduction, affecting skeletal and metabolic health differently in males and females.

Stable Network Homeostasis during Multi-Level Postnatal Maturation of the Mouse Tuberoinfundibular Dopamine-Prolactin Axis

This study investigates the postnatal maturation of TIDA neurons in mice, showing that while individual cell properties change, network stability and Prl levels increase.

Sustained GnRH Agonism Alters Endocrine Dynamics and Pubertal Progression in Juvenile Rats

This study examines the effects of sustained GnRH agonism on pubertal progression and HPG axis dynamics in juvenile rats, finding sex-specific changes in gonadal size, hormone levels, and gene expression.

Distinct afferent signatures onto anterior and posterior VMHvl subdomains and their progesterone receptor-expressing neurons

The paper identifies distinct afferent inputs to anterior and posterior VMHvl subdomains and their progesterone receptor-expressing neurons, revealing circuit mechanisms underlying female sexual behavior regulation.

Menarche onset is an inflection point for mental health and brain development

The paper identifies menarche as an inflection point for mental health and brain development in adolescent females using longitudinal data.

Microglia Rank signaling regulates GnRH function and the Hypothalamic-Pituitary-Gonadal axis

The paper shows that microglia use Rank signaling to regulate GnRH function and the HPG axis, leading to hypogonadotropic hypogonadism when disrupted.

Knockout of PI4-Kinase A in GnRH Neurons Causes their Prepubertal Death

This study shows that PI4-kinase A is essential for postnatal survival of GnRH neurons, leading to infertility in knockout mice, but not for embryonic development.

Bioengineered recombinant kisspeptins with extended half-life exhibit novel peripheral function in a large-animal model

This study bioengineers kisspeptins with extended half-life and demonstrates their novel peripheral function in a large-animal model.

Integrating Models to Decode the GnRH Pulse Generator

This paper uses computational modeling to integrate experimental data and decode the dynamics of the GnRH pulse generator, focusing on the KNDy network and its modulation by external factors.

Joint model shows association of Mapuche genetic ancestry and longitudinal BMI with early menarche

The paper develops a joint statistical model to show that higher Mapuche genetic ancestry and accelerating BMI trajectories independently increase the likelihood of early menarche in admixed girls.

High-Fat Diet Induces Epigenetic and Metabolic Changes in Kisspeptin Neurons in Association with Obesity and Male Secondary Hypogonadism

This study shows that a high-fat diet alters epigenetic and metabolic processes in Kisspeptin neurons, contributing to male hypogonadism in mice.

Decoding the pituitary gonadotrope regulatory architecture governing the preovulatory surge in vivo

The paper identifies a biphasic gene regulatory network in rat pituitary gonadotropes that controls the preovulatory hormone surge, showing FSH surge is driven by dynamic Fshb transcription rather than Lhb upregulation.

Post-inhibitory rebound firing drives hypothalamic activation for male mating

The paper identifies post-inhibitory rebound firing as a mechanism by which inhibition promotes activation in limbic circuits to drive male mating.

The olfactory organ is a site for neuroendocrine modulation of reproduction in zebrafish

The paper investigates the role of Gnrh in zebrafish reproduction, showing that waterborne Gnrh modulates the hypothalamic-pituitary axis and that gnrh-r3 knockout leads to infertility.

GABA Neurons in the Amygdala play a central Role in Urocortin-3-Mediated Stress Suppression of Reproduction

This study identifies two anti-correlated GABA subpopulations in the MePD that mediate UCN3-mediated stress suppression of reproduction through mutual inhibition and downstream LH regulation.

Neuronal plasticity at puberty in hypothalamic neurons controlling fertility in female mice

This study investigates neuronal plasticity in Kiss1ARC neurons during puberty in female mice, showing electrophysiological and gene expression changes that enable mature function in the HPG axis.

Progressive hypothalamic neuroinflammation after ovariectomy in mice parallels age-related transcriptomic changes in the female human hypothalamus

This study examines hypothalamic changes in mice after ovariectomy, finding time-dependent neuroinflammation and gene expression patterns that mirror human age-related changes.

Gonadotrophs have a dual origin, with most derived from pituitary stem cells during minipuberty.

The paper shows that most gonadotrophs in adults originate from postnatal pituitary stem cells during minipuberty, while embryonic gonadotrophs are maintained, revealing a dual origin.

Comprehensive chemotyping, and the gonadal regulation, of seven kisspeptinergic neuronal populations in the mouse brain

The paper identifies seven distinct kisspeptin neuronal chemotypes in the mouse brain and shows gonadectomy alters their expression patterns.

IGF-1 Acts through Kiss1-expressing Cells to Influence Metabolism and Reproduction

This study shows that IGF-1 receptor in Kiss1-expressing cells affects metabolism and reproduction differently in males and females.

Temporal Analysis of Pituitary Transcriptional Dynamics in Mice Models of Hypopituitarism During Postnatal Development

The paper analyzes pituitary transcriptional dynamics in mouse models of congenital hypopituitarism across developmental stages, revealing distinct gene expression patterns and functional impairments in Prop1 mutants.

The preoptic Kisspeptin/nNOS/GnRH (KiNG) neuronal network regulates rhythmic LH release through a dual activation-inhibition mechanism

This study investigates the KiNG neuronal network's role in regulating GnRH/LH release through excitatory and inhibitory mechanisms involving kisspeptin and nNOS neurons.

Kisspeptin modulates sex-like phenotypes in the neonatal period

This study investigates the effect of neonatal Kiss1 signaling blockage on sex-like phenotypes in rats, finding that Kiss1 modulates testosterone surge and sexual behavior with sex-specific effects.

Estrogen-regulated peptidergic input to gonadotropin-releasing hormone neurons from the lateral septal kisspeptin network

The paper identifies estrogen-regulated peptidergic neurons in the lateral septum that project to gonadotropin-releasing hormone neurons and reveals their unique transcriptome and potential evolutionary conservation.

Lifelong impacts of puberty timing on human plasma metabolic profiles

This paper investigates the causal effect of puberty timing on plasma metabolites using Mendelian randomization and finds moderate evidence of causal relationships for 16 metabolites after adjusting for confounders.