Hypothalamic control of reproductive hormones

This study identifies Prokr2 expression in terminal nerve neurons and links their dysfunction to Kallmann syndrome through single-cell RNA sequencing and genetic tracing in mice.

The paper identifies genetic variants associated with pubertal stage transitions and BMI using joint models in a Latino cohort, finding 43 novel associations and links between Native American ancestry and earlier Tanner 2 stage onset in boys.

This study profiles GnRH neurons in mice to uncover developmental gene expression patterns linked to human reproductive processes.

The paper investigates the role of membrane estrogen receptor alpha in the positive feedback of estrogens on LH secretion using E4 and C451A-ER mice.

The paper identifies POU6F2 mutations in IHH patients, showing isoform1 regulates GnRH expression and variants disrupt this function, contributing to pubertal failure.

This study profiles gene and miRNA expression in mouse pituitaries across postnatal ages to identify sex-biased gene regulation and cell-type proportion differences during development.

The paper identifies leptin-hyperpolarized neurons in the PMv that coexpress DAT and prolactin receptor, and shows they inhibit reproduction via AgRP, with computational modeling linking these findings to metabolic control of reproduction.

The paper investigates how pubertal sex hormones regulate transcriptional changes in the medial preoptic area of mice during puberty, revealing sexually dimorphic gene regulatory networks.

This study shows that selective ablation of adult hypothalamic GFAP-expressing tanycytes causes hypogonadotropic hypogonadism in males by reducing GnRH neurons and testosterone levels.

This study shows that estradiol-induced progesterone synthesis in the rostral hypothalamus develops post-puberty in female mice and correlates with increased membrane ER expression in hypothalamic astrocytes.

The paper shows that balanced release of NPFF and GnRH in TN-GnRH neurons modulates male sexual behavior in medaka, with double knockout showing normal behavior.

This study investigates the role of RNF216/TRIAD3 in the hypothalamic-pituitary-gonadal axis using cell line and mouse models, finding sex-specific effects on reproductive function.

This study investigates how food scarcity and temperature affect photoperiodic responses in voles, revealing species-specific hypothalamic gene regulation of reproductive development.

The paper shows that male mice have nearly as many Kiss1RP3V neurons as females, which can stimulate testosterone synthesis when activated.

The paper identifies Pclo mutations in rats that affect reproductive behavior and link to depression-associated genes.

The paper investigates the role of neuroprogesterone signaling through Src kinase in RP3V neurons to trigger the luteinizing hormone surge in female rats.

The paper identifies ASPHD1 as a key driver of reproductive traits in the 16p11.2 locus using biobank data, Mendelian randomization, and animal models.

This study shows that neuroprogesterone induces the LH surge via RP3V kisspeptin neurons in female rats by restoring the surge when kisspeptin is administered.

This study identifies 78 genetic signals for male puberty timing using a large sample of men, revealing links to hair color and health outcomes.

This study performs a GWAS meta-analysis of menstrual cycle length in European women, confirming the FSHB locus association and identifying four novel signals linked to the HPG axis.