Optical Imaging and Spectroscopy Techniques

An Open-Source, Excitation-Resolved UV-NIR Imaging Platform for Bioluminescence, Luminescence-Decay, and Chemical Discrimination Measurements

AURORA-MSI is an open-source multispectral imaging platform that enables excitation-resolved measurements of bioluminescence, luminescence decay, and chemical discrimination without photon-counting instrumentation.

Physics-Informed Neural Network for Mapping Vascular and Tissue Dynamics Using Laser Speckle Contrast Imaging

This paper develops a physics-informed neural network to rapidly estimate vascular and tissue dynamics from laser speckle contrast imaging data without ground-truth labels.

Visual Semantic Encoding and Identification of Naturalistic Movies via High-Density Diffuse Optical Tomography

This study uses HD-DOT to encode and decode semantic representations from naturalistic movies, showing it can capture high-dimensional semantic maps similar to fMRI.

A Novel Technique for Fluorescence Lifetime Tomography

This paper introduces a deep learning method called AUTO-FLI for 3D fluorescence lifetime imaging in deep tissues, showing it can accurately reconstruct intensity and lifetime data in scattering media.

Time-Resolved Laser Speckle Contrast Imaging (TR-LSCI) of Cerebral Blood Flow Response to Intracranial Pressure Elevation

This paper develops and applies TR-LSCI for depth-sensitive, high-speed CBF imaging during ICP perturbations, revealing phase-dependent autoregulation transitions.

Multimodal 3D light-field and laser-speckle endoscopy

This paper introduces a multimodal 3D endoscope combining light-field and laser-speckle imaging to capture 3D structure and blood flow during surgery.

Characterizing developmental changes in infant habituation using functional change point detection

This study uses functional change point detection to analyze infant fNIRS data and finds earlier habituation timing in older infants.

Prior photon measurement density function constructed in a standard channel space for functional near-infrared spectroscopy

The paper constructs a prior photon measurement density function (PMDF) using a standard channel space and structural MRI database, outperforming template-based PMDF in fNIRS studies.

Indocyanine green excitation-emission matrix characterization: excitation-dependent emission shifts and application-specific spectra

This paper characterizes indocyanine green (ICG) excitation-emission matrices in different microenvironments, showing excitation-dependent emission and its implications for fluorescence-guided surgery.

Fast in vivo deep-tissue 3D imaging with selective-illumination NIR-II light-field microscopy and aberration-corrected implicit neural representation

This paper introduces a fast 3D in vivo imaging technique using NIR-II light-field microscopy with aberration correction, enabling high-speed visualization of biological processes in mice.

Laser Speckle Orthogonal Contrast Imaging Calibration by Replicating Red Blood Cells Scattering Statistics with a Moving Reference Diffuser

This paper introduces a calibration method for Laser Speckle Orthogonal Contrast Imaging using a moving reference diffuser to replicate red blood cell scattering statistics, enabling standardized microcirculation activity quantification.

Evaluating the reliability of functional near-infrared spectroscopy data in the context of a reasoning paradigm

This study evaluates fNIRS reliability in a reasoning task, finding robust activation patterns, diminishing returns with more data, and high reliability for functional connectivity.

Mechanisms of surface and volume light scattering from Caenorhabditis elegans revealed by angle-resolved measurements

This study investigates light scattering mechanisms in C. elegans using angle-resolved measurements and simulations, identifying surface and volume scattering components and their impact on image contrast.

Effect of sleep stages on patterns of fNIRS hemodynamic response to auditory paradigms in one-month-old Gambian and UK infants

This study examines how sleep stages affect fNIRS-measured hemodynamic responses to auditory stimuli in one-month-old Gambian and UK infants, finding cohort-specific differences in response patterns.

Whole-Slide Mapping of Tumor Tissue Fiber Architecture via Computational Scattered Light Imaging

This paper introduces ComSLI, a computational method to map collagen fiber orientation in paraffin-treated tumor tissues, enabling analysis of tumor growth and desmoplastic reactions.

High dynamic range shortwave infrared (SWIR) imaging of mice with an InGaAs camera

This paper develops a high dynamic range (HDR) SWIR imaging method for mice using InGaAs cameras, enabling quantitative fluorescence analysis across wide intensity ranges.

Dynamic Causal Modelling for Functional Near-Infrared Spectroscopy Using Spatial Priors Derived from Diffuse Optical Tomography

This paper improves dynamic causal modeling for fNIRS by using source-level locations from diffuse optical tomography, showing better performance in estimating brain connectivity during a response inhibition task.

Optimizing short-channel regression in fNIRS: an empirical evaluation with ecological audiovisual stimuli

This study evaluates SC regression methods in fNIRS to improve signal quality, finding that pooled and orthogonalized SC signals enhance detection of stimulus-specific responses.

Investigating the effect of channel pruning on functional near-infrared spectroscopy data collected from children aged 5-24 months

This study compares channel pruning methods for infant fNIRS data, finding that QT-NIRS provides better signal quality and retention than CV pruning, with lower thresholds recommended for infants.

fNIRS Characterization of Temporal Potentiation During Optimized Nerve Stimulation

This study uses fNIRS to analyze cortical responses to optimized nerve stimulation, finding temporal potentiation and nonlinear adaptation in the sensorimotor network.

The protocol for mesoscopic wide-field optical imaging in mice: from zero to hero

This paper provides protocols for mesoscopic wide-field optical brain imaging in mice, enabling visualization of the dorsal cortex and simultaneous measurement of haemodynamics and intracellular parameters.

High precision fluorescence tomography-guided system for pre-clinical radiation research: system design and validation

The paper develops a high-precision fluorescence tomography system integrated with a small animal irradiator for pre-clinical radiation research, achieving sub-millimeter localization accuracy in both phantom and in vivo models.

Mapping human cerebral blood flow with high-density, multi-channel speckle contrast optical spectroscopy

This study develops a multi-channel SCOS system to map human cerebral blood flow changes during brain activation, showing spatial heterogeneity and validating its accuracy with a phantom.

Anisotropic light propagation in human brain white matter

This study characterizes anisotropic light scattering in human white matter by measuring tensor components and correlating them with axon fiber orientation.

Laser Speckle Particle Sizer (SPARSE) Informs the Size Distribution of Tissue Granularities

The paper introduces SPARSE, a laser-based method to measure particle size distribution in biological tissues and fluids without prior knowledge of refractive index or scattering concentration.

On-skin, micro-objective enabled camera module for speckle contrast optical spectroscopy/tomography

This paper introduces a compact, on-skin camera module for speckle contrast optical spectroscopy/tomography, validated on phantoms and human subjects to track blood flow with high sensitivity and signal-to-noise ratio.

Wide-field optical redox imaging with leading-edge detection for assessment of patient-derived cancer organoids

This study uses wide-field optical redox imaging to assess treatment response and heterogeneity in colorectal cancer organoids, showing improved sensitivity and accuracy compared to existing methods.

Mapping functional hemodynamic and metabolic responses to dementia: a broadband spectroscopy pilot study

This study uses broadband near-infrared spectroscopy to assess hemodynamic and metabolic responses in dementia patients, finding strong correlations between oxCCO features and clinical markers.

High-Density Multi-Distance fNIRS Enhances Detection of Brain Activity during a Word-Color Stroop Task

This study compares high-density and sparse fNIRS arrays in detecting brain activity during a Word-Color Stroop task, finding HD arrays provide better localization and sensitivity in image space.

A Novel Infrared-Based Non-Invasive Brain Stimulation Approach for Neurological Disorders

This paper proposes an infrared-based non-invasive brain stimulation method for neurological disorders, showing its feasibility through photon modeling and experimental evaluations.