Cytomegalovirus and herpesvirus research

Endogenization and excision of human herpesvirus 6 in human genomes

The paper analyzes HHV-6 integration in human genomes, identifies co-evolution with chr22q, and reports evidence of in vivo excision and reactivation.

A Molecular Mechanism for Probabilistic Bet-hedging and its Role in Viral Latency

The paper identifies stochastic variability in viral tegument protein abundance as a mechanism for probabilistic bet hedging between viral replication and latency in herpesvirus.

Inherited chromosomally integrated HHV-6 demonstrates tissue-specific RNA expression in vivo that correlates with increased antibody immune response.

This study identifies tissue-specific RNA expression of integrated HHV-6A/B in vivo and links it to increased antibody responses against specific viral antigens.

EGR1 transcriptional control of human cytomegalovirus latency

This study identifies EGR1 as a key transcription factor regulated by EGFR signaling that promotes CMV latency by enhancing UL138 expression in CD34+ HPCs.

Multiple-Strain Infections of Human Cytomegalovirus with High Genomic Diversity are Common In Breast Milk from HIV-Positive Women in Zambia

The paper investigates HCMV strain diversity in breast milk from HIV-positive women in Zambia, finding multiple-strain infections with high genotypic complexity.

RNA sequencing of the in vivo human herpesvirus 6B transcriptome to identify targets for clinical assays distinguishing between latent and active infections

This study uses RNA sequencing to analyze HHV-6B transcriptomes in various samples to identify diagnostic targets distinguishing latent from active infections.

Feedback-mediated signal conversion promotes viral fitness

The paper shows that positive feedback in HCMV IE1 protein sustains lytic gene expression despite transient tegument transactivator signals, enhancing viral fitness.

Differences in cognitive functions between cytomegalovirus-infected and cytomegalovirus-free university students: a case-control study

This study compares cognitive functions between CMV-infected and CMV-free university students, finding higher IQ in infected individuals despite lower antibody concentrations.

Copy number heterogeneity, large origin tandem repeats, and interspecies recombination in HHV-6A and HHV-6B reference strains

The paper uses next-generation sequencing to analyze copy number variations and interspecies recombination in HHV-6A and HHV-6B reference strains, revealing large tandem repeats and a novel recombinant strain.