Sleep and Wakefulness Research

This study shows that longer sleep spindle duration during NREM sleep improves post-sleep working memory performance and decoding of latent memory representations.

This study uses a state space model to analyze how acute total and chronic partial sleep loss alter sleep state boundaries and dynamics, finding distinct changes in REM and slow wave sleep.

This study shows that sleep continuity after encoding affects memory accuracy and neural reinstatement of context memory in younger and older adults.

The paper uses a biophysical model to show that slow-wave and delta waves during sleep differentially control memory consolidation and forgetting through distinct synaptic mechanisms.

The paper shows that sleep enhances spatial schema memory formation in humans, with benefits linked to frontal cortical slow oscillation-spindle coupling.

This study shows that sleep helps toddlers consolidate spatial context memory, similar to adults, despite immature hippocampal function.

The paper identifies EGR2 as a conserved sleep regulator by analyzing sub-threshold genetic signals across sleep-related traits in multiple species.

This study uses a computational model to show that age-related loss of recurrent excitation disrupts slow oscillations in sleep, impairing memory consolidation.

This paper links video-based eye movements to cortical and pupil-based arousal markers during sleep, showing state-dependent correlations and offering a non-invasive tool for sleep phenotyping.

The paper shows that theta phase-locked memory reactivation during REM sleep reduces the emotional tone of memories without affecting recognition.

This study identifies a neuroimmune circuit linking chronic stress, REM sleep, and behavioral susceptibility through monocyte-driven microglial remodeling and PV neuron activity.

The paper identifies genes involved in sleep homeostasis in Drosophila by analyzing transcriptomic responses across multiple sleep-wake manipulation methods and datasets.

This study identifies MCH neurons in the hypothalamus as a key circuit linking tau pathology to sleep disruption and shows their potential as a therapeutic target.

This study shows that timing of auditory stimulation during sleep affects spindle dynamics and memory consolidation, with post-spindle stimulation improving motor memory but not word recall.

This study examines yawn functions in juvenile Emperor cichlids, finding support for arousal, social contagion, and sex-specific differences in yawn timing and frequency.

The paper identifies a hypothalamic-brainstem activity sequence that drives arousal fluctuations and cortical hemodynamics during drowsiness using fMRI.

This study investigates how nocturnal awakenings influence dream recall, finding that specific awakening characteristics, not just frequency, affect different types of dream recall.

The paper maps whole-brain neural activity during emergence from isoflurane anesthesia in mice and finds selective subcortical activation rather than global cortical reactivation.

This study uses EEG/EMG recordings and machine learning to analyze how time-restricted feeding affects sleep microarchitecture in mice on a high-fat diet, finding it reduces sleep fragmentation and enhances specific NREM substates.

This study examines longitudinal changes in sleep EEG biomarkers of memory consolidation in middle-aged and older adults, finding declines in SO-sigma coupling and sleep spindle measures linked to synaptic integrity and memory decline.

This study shows that ramelteon increases hippocampal ripple occurrence and amplitude during NREM sleep in mice, potentially supporting its cognitive-enhancing effects.

This study shows that targeted memory reactivation during sleep spindles improves recall-based memory retention, with spindle temporal clustering affecting different memory outcomes.

The paper investigates how theta-band brain synchronization during immediate and post-sleep recall sessions in children supports memory recall dynamics and performance.

This study inhibits hippocampal activity during specific sleep phases in rats and shows that memory consolidation requires hippocampal engagement during cortical slow oscillation upstates.

This study shows that closed-loop auditory stimulation can restore sleep homeostasis in Alzheimer's and Parkinson's disease models by modulating cortical synchrony and arousal.

This study shows that memory reactivation during sleep promotes structural abstraction, enabling knowledge transfer between categories with no feature overlap.

The paper identifies cell-type-specific genes regulating sleep by mapping GWAS variants to effector genes in human and Drosophila models, revealing ruby/AP3B2 as a conserved glial regulator.

The paper shows that NREM sleep oscillations drive synaptic proteome remodelling, promoting stabilization and memory consolidation, while altered oscillations in a disorder lead to synaptic weakening.

This study decomposes representational drift in mice olfactory cortex during wake and sleep, showing distinct transformations driven by each state.

This paper identifies Vgll2 and Tead1 as key regulators of Hcrt neuron generation in mouse and human, showing their role in differentiation and potential for cell therapy.