Topic · Parasitology · Immunology and Microbiology

Parasitic Infections and Diagnostics

OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.

69 papers

Global population genomics of two subspecies of Cryptosporidium hominis during 500 years of evolution

Swapnil Tichkule, Simone M. Cacciò, Guy Robinson, Rachel M. Chalmers, Ivo Müeller, Samantha J. Emery‐Corbin, Daniel Eibach, Kevin Morris Tyler, Cock van Oosterhout, Aaron R. Jex

The paper analyzes global population genomics of two C. hominis subspecies over 500 years, identifying divergence, transmission patterns, and introgression between them.

Molecular Biology and Evolution · Mar 16, 2022Peer-reviewedGenomics

Development of duplex real time PCR for quick detection of Cryptosporidia in goats

Atul Kumar Sharma, K. Gururaj, Rama Kanta Sharma, Anjana Goel, Souvik Paul, Dinesh Kumar Sharma

This paper develops a duplex RT-qPCR assay to detect active Cryptosporidium infections in goats by targeting mRNA transcripts of the COWP gene and 18S rRNA gene.

bioRxiv · Feb 23, 2022 · PreprintMolecular Biology

Fully resolved assembly of Cryptosporidium parvum

Vipin K. Menon, Pablo C. Okhuysen, Cynthia L. Chappell, Medhat Mahmoud, Medhat Mahmoud, Qingchang Meng, HarshaVardhan Doddapaneni, Vanesa Vee, Yi Han, Sejal Salvi, Sravya Venkata Bhamidipati, Kavya Kottapalli, George Weissenberger, Hua Min Shen, Matthew Clayton Ross, , Fritz Joachim Sedlazeck

The paper presents a high-quality, complete reference genome for Cryptosporidium parvum using Oxford Nanopore and Illumina reads, enabling comprehensive genomic studies.

GigaScience · Jan 1, 2022Peer-reviewedGenomics

Long-read assembly and comparative evidence-based reanalysis of Cryptosporidium genome sequences reveal new biological insights

Rodrigo P. Baptista, Yiran Li, Adam Sateriale, Mandy J Sanders, Karen L. Brooks, Alan Tracey, Brendan R. E. Ansell, Aaron R. Jex, Garrett W. Cooper, Ethan D. Smith, Rui Xiao, Jennifer E. Dumaine, Peter Georgeson, Bernard J. Pope, Matthew Berriman, , Jessica C. Kissinger

The paper presents a new high-quality genome assembly and annotation for Cryptosporidium parvum IOWA, revealing structural and functional insights into its genome and evolutionary relationships with related species.

Genome Research · Jan 1, 2022Peer-reviewedGenomics

Stage-Specific Long Non-coding RNAs in Cryptosporidium parvum as Revealed by Stranded RNA-Seq

Yiran Li, Rodrigo P. Baptista, Adam Sateriale, Boris Striepen, Jessica C. Kissinger

This study identifies 396 novel lncRNAs in Cryptosporidium parvum using RNA-seq, showing differential expression and potential regulatory roles.

Frontiers in Cellular and Infection Microbiology · Jan 14, 2021Peer-reviewedGenomics

Genome-wide association study of cryptosporidiosis in infants implicates PRKCA

Genevieve L. Wojcik, Poonum S. Korpe, Chelsea S. Marie, Alexander J. Mentzer, Tommy Carstensen, Josyf C. Mychaleckyj, Beth D. Kirkpatrick, Stephen S. Rich, PATRICK J. CONCANNON, Abu Syed Golam Faruque, Rashidul Haque, William A. Petri, Priya Duggal

This paper conducts a GWAS to identify genetic variants associated with symptomatic cryptosporidiosis in infants, finding a strong association with an intronic SNP in PRKCA.

mBio · Feb 3, 2020Peer-reviewedGenetics

Whole genome sequencing of dog specific assemblages C and D of Giardia duodenalis from single and pooled cysts indicates host associated genes

Frans N. J. Kooyman, Jaap A. Wagenaar, Aldert Zomer

The paper sequences whole genomes of Giardia duodenalis assemblages C and D from dog feces, revealing host-associated gene differences.

Microbial Genomics · Dec 1, 2019Peer-reviewedMolecular Biology

Nanopore sequencing of Giardia reveals widespread intra-isolate structural variation

Stephen M. J. Pollo, Sarah Julia Reiling, Janneke Wit, Matthew L. Workentine, Rebecca A. Guy, G. William Batoff, Janet Yee, Brent R. Dixon, James D. Wasmuth

The paper uses Nanopore sequencing to generate high-quality genomes and identify structural variants in Giardia isolates, revealing heterozygosity and variant-specific surface proteins.

bioRxiv · Sep 19, 2019 · PreprintGenomics

First report and multilocus genotyping of Enterocytozoon bieneusi from Tibetan pigs in southwestern China

Run Luo, Leiqiong Xiang, Haifeng Liu, Zhijun Zhong, Li Liu, Lei Deng, Yuan Song, Ling Liu, Xiangming Huang, Ziyao Zhou, Hualin Fu, Yan Luo, Guangneng Peng

This study reports the prevalence and genetic diversity of E. bieneusi in Tibetan pigs, identifying novel genotypes and zoonotic potential.

Parasite · Jan 1, 2019Peer-reviewedGenetics