Advanced Neuroimaging Techniques and Applications

DTI-ALPS PRIMARILY REFLECTS WHITE MATTER DIFFUSION DISPERSION AND MICROSTRUCTURAL HETEROGENEITY IN NEURODEGENERATION: INSIGHTS FROM MULTI-MODAL MRI

This study investigates DTI-ALPS as a marker of glymphatic flow in neurodegeneration and finds it primarily reflects white matter diffusion dispersion and microstructural heterogeneity rather than glymphatic flow.

T2 relaxometry for myelin water fraction: an ex vivo brain imaging study

This study validates and compares TSE and GRASE techniques for myelin water imaging in postmortem human brains, showing moderate to strong agreement between the sequences.

Sex-stratified fixel-based analysis reveals reduced frontal fibre density in males with first-episode of psychosis

This study uses fixel-based analysis to find reduced frontal fibre density in male first-episode psychosis patients compared to controls, with no significant differences in females.

Diffusion MRI Tractography Predicts Electrophysiological Connectivity and Explains Spectral Signatures of Evoked Potentials in the Human Brain

The paper uses diffusion MRI and SEEG to predict electrophysiological connectivity and explain evoked potential spectral signatures in the human brain.

Tractography from Serial Optical Coherence Tomography: How and Why?

This paper develops a method for microscale white matter tractography using S-OCT and validates it on simulated and mouse brain data, showing improved ODF estimation and tractography performance.

Test-Retest Reproducibility of Single- and Cross-Population White Matter Atlases in Diffusion MRI Tractography

This study evaluates whether cross-population white matter atlases improve test-retest reproducibility compared to single-population atlases in diffusion MRI tractography.

Postnatal maturation of putamen microstructure accompanies topographic white matter connectivity and altered circuits in autism

The paper examines the postnatal development of putamen microstructure and white matter connectivity in autism, finding preserved organization with increased prefrontal connectivity.

Reproducibility of Diffusion, Shape, and Connectivity Metrics Across Scanners: Implications for Multi-Site Tractography

The paper evaluates the reproducibility of diffusion, shape, and connectivity metrics across scanners in multi-site tractography studies and finds shape metrics show the highest reproducibility.

Longitudinal quantitative MRI of whole human brains during formaldehyde immersion, PBS wash-out, and tissue volume change

The paper quantifies how MRI parameters and tissue volume change in human brains during fixation and PBS immersion, providing a resource for linking in vivo MRI to postmortem data.

Diffusion MR Microscopy of the Human Hippocampus at 50 μm Resolution at 14.1 T for 3D Virtual Histology

This paper demonstrates diffusion MR microscopy at high resolution for 3D virtual histology of the human hippocampus, showing correspondence with histological markers and revealing structural changes in Alzheimer's disease.

OCTOPUS: A versatile open-source tool creating realistic numericalbrain cells

OCTOPUS generates realistic digital brain cells with complex geometries to improve dMRI signal modeling and validate biophysical models.

Diffusion tensor imaging of whole human brains during long-term formaldehyde fixation: Temporal evolution of diffusion parameters, post-mortem conditions, and dependence on tissue structure

This study examines how post-mortem tissue conditions and fixation progression affect diffusion tensor imaging parameters in whole human brains, finding that mean diffusivity is a robust marker while fractional anisotropy requires microstructure-aware interpretation.

Assessing nonlinear associations between body mass index and brain microstructure across adolescence in the ABCD Study

This study examines how BMI relates to brain microstructure across adolescence, finding nonlinear associations that intensify at higher BMI percentiles.

The microstructure-weighted human connectome: network properties and structure-function correlations across spatial scales

This study evaluates microstructure-weighted connectomes using diffusion MRI data and finds that DePerp provides the most consistent structure-function coupling across spatial scales.

Weakening of subcortical and strengthening of cortical visual pathways across early adolescence

The paper uses longitudinal dMRI data to show that subcortical visual pathways weaken while cortical pathways strengthen during early adolescence, with both linked to faster visual processing.

Multidimensional diffusion MRI reveals heterogeneous microstructural remodeling associated with amyloid pathology

This study uses multidimensional diffusion MRI to show increased microstructural heterogeneity in 5xFAD mouse brains compared to wild-type, associated with amyloid pathology but not widespread degeneration.

Anatomical White Matter Tracts Span the Cortical Hierarchy to Support Cognitive Diversity

The paper shows that white matter tracts are positioned within the cortical hierarchy to support specific cognitive functions and connect regions with greater cognitive diversity.

A multi-b-value test-retest diffusion MRI brain dataset for model validation and reproducibility assessment

The paper introduces a densely sampled longitudinal diffusion MRI dataset for validating dMRI techniques and assessing reproducibility.

10.5 Tesla High-Resolution Macaque Brain MRI for In vivo and Ex vivo Connectivity Studies

This paper presents high-resolution diffusion MRI techniques for in vivo and ex vivo macaque brain imaging at 10.5 Tesla, enabling detailed connectivity studies.

Genetic architecture and biological relevance of intrinsic white matter functional activity

This study identifies genetic associations with white matter functional activity, showing heritability and links to cognition but not neuropsychiatric disorders.

Developmental Changes in Gray Matter Microstructure and Local Brain Connectivity Support Inhibitory Control from Adolescence to Young Adulthood

Cortico-striato-pallido-thalamic loop: Effects of age on white matter neurite microstructural properties and its spatial gradients

The paper examines age-related changes in white matter microstructural properties within the cortico-striato-pallido-thalamic loop using NODDI, finding age-sensitive spatial gradients and an inverted-U association with age.

Mapping Whole-Brain Factors of Microstructural Similarity with Diffusion MRI

The paper identifies shared dimensions of variation in diffusion MRI statistics and maps spatial patterns of microstructural similarity across the brain.

Corticospinal Tractometry and Whole-Brain Connectometry of Hand Dexterity in Chronic Stroke and Traumatic Brain Injury

The paper uses diffusion MRI to analyze white matter correlates of hand dexterity in stroke and TBI patients, finding CST features predict dexterity in stroke but not TBI, and whole-brain connectometry reveals distributed pathways associated with different dexterity tests.

A Mechanical Theory for the Formation of Short Association Fibers in the Brain

This study shows mechanical forces during cortical folding guide the formation of short association fibers in the brain, explaining their U-shaped trajectories and prevalence between gyri.

Neural fiber orientations across spinal cord gray matter

The paper maps neurite orientations across the spinal cord using MRI and microscopy, revealing regional differences in fiber organization.

SILICA: Streamline Independent Component Analysis for Trajectory-Resolved White Matter Decomposition

SILICA decomposes white matter tractograms into population-level statistical components while preserving individual streamline geometry, revealing recognizable brain systems and enabling trajectory-resolved visualization.

Quantifying visual pathway overlap to identify training-related microstructural change in hemianopia

The paper quantifies tract overlap in visual pathways to assess training-related microstructural changes in hemianopia patients using diffusion MRI.

Benchmarking Generalizability in Deep Learning-Based White Matter Tract Segmentation

This study benchmarks deep learning models for white matter tract segmentation across diverse datasets, finding that CNN-based models perform best within their training domain but degrade under domain shifts, and introduces an ensemble method to mitigate this issue.

Testing diffusion-derived orientation priors for streamline modelling of the MRI-visible glioblastoma core: the BRIAN framework

The paper introduces BRIAN, a diffusion-informed simulator for glioblastoma spread modeling, showing directional tracking improves agreement with MRI-visible tumours but not necessarily with richer angular reconstructions.