Muscle metabolism and nutrition

Exploring the multifactorial causes and therapeutic strategies for anabolic resistance in sarcopenia: A systems modeling study

This study uses mathematical modeling to investigate the multifactorial causes of anabolic resistance in sarcopenia and evaluates therapeutic strategies to restore muscle protein metabolism.

Anabolic and catabolic responses to different modes of exercise in patients with chronic kidney disease

This study examines how different exercise types affect skeletal muscle in CKD patients, finding that combined aerobic-resistance exercise improves anabolic signaling and myogenic responses compared to aerobic exercise alone.

Turnover rates of human muscle proteins in vivo reported in fractional, mole and absolute units.

The paper compares fractional, mole, and absolute turnover rates of human muscle proteins, finding that mole and absolute rates better account for abundance differences in certain contexts.

Human skeletal muscle possesses both reversible proteomic signatures and a retained proteomic memory after repeated resistance training

This study shows that resistance training induces reversible and retained proteomic changes in human skeletal muscle, suggesting a proteomic memory of muscle growth.

Endurance exercise with reduced muscle glycogen content influences substrate utilization and attenuates acute mTORC1- and autophagic signaling in human type I and type II muscle fibers

This study examines how endurance exercise with reduced muscle glycogen affects substrate utilization and signaling in human muscle fibers, finding altered fatty acid metabolism and mTORC1-autophagy dynamics.

Anabolic sensitivity in healthy, lean, older men is associated with higher expression of amino acid sensors and mTORC1 activators

This study shows that lean, healthy older men maintain anabolic sensitivity to amino acids and exercise, with increased mTORC1 signaling and muscle protein synthesis, suggesting aging alone does not cause anabolic resistance.

Skeletal muscle myosin heavy chain protein fragmentation as a potential marker of protein degradation in response to resistance training and disuse atrophy

This study examines how resistance exercise and disuse atrophy affect myosin heavy chain (MyHC) protein fragmentation in humans, finding increased fragmentation post-exercise and during atrophy, with adaptive responses after training.

Kinetic modeling of leucine-mediated signaling and protein metabolism in human skeletal muscle

The paper develops a kinetic model of leucine-mediated mTOR signaling and protein metabolism in human skeletal muscle, showing that basal p70S6K levels determine MPS and insulin signaling affects net protein balance.