Muscle metabolism and nutrition

The Energetic Cost of Building Human Skeletal Muscle

The paper calculates the energetic cost of building human skeletal muscle using a bottom-up model, finding a central estimate of 14570 kJ/kg (3481 kcal/kg) of metabolizable energy required.

CreaSol(R) SSAT (Stabilized Tyrosol) Enhances Creatine on Muscle Performance and Anti-fatigue Capacity in Trained Mice

This study shows that combining tyrosol with creatine monohydrate improves muscle strength and endurance in trained mice, with greater recovery capacity after exhaustive exercise.

Amino Acid-Stimulated Muscle Protein Synthesis is Attenuated During Early Recovery from Aerobic Exercise in Individuals with Obesity

Exploring the multifactorial causes and therapeutic strategies for anabolic resistance in sarcopenia: A systems modeling study

This study uses mathematical modeling to investigate the multifactorial causes of anabolic resistance in sarcopenia and evaluates therapeutic strategies to restore muscle protein metabolism.

Plasma metabolite responses to an oral protein tolerance test differ between young and sarcopenic participants and suggest altered anabolic sensitivity

This study uses an oral protein tolerance test combined with metabolomics to show that sarcopenic older adults have slower postprandial decline in essential amino acids compared to young controls, suggesting altered anabolic sensitivity.

Ageing blunts the phospho-proteomic response to resistance exercise in humans

This study shows that ageing reduces the phospho-proteomic response to resistance exercise in human skeletal muscle, despite normal mTORC1 activation, suggesting new therapeutic targets for aged muscle.

Dynamic proteomic profiling reveals protein-specific regulation of synthesis rates underpinning the divergent adaptation of human muscle to endurance and resistance training

This study identifies protein-specific synthesis rate changes in human muscle under endurance and resistance training, revealing mode-specific adaptations in subcellular protein subsets.

Anabolic and catabolic responses to different modes of exercise in patients with chronic kidney disease

This study examines how different exercise types affect skeletal muscle in CKD patients, finding that combined aerobic-resistance exercise improves anabolic signaling and myogenic responses compared to aerobic exercise alone.

Large increases in resistance training volume do not impair skeletal muscle hypertrophy or anabolic-catabolic molecular signalling in trained individuals

This study shows that a large increase in resistance training volume does not hinder muscle hypertrophy or anabolic-catabolic signaling in trained individuals.

Subcellular proteomic profiling of human skeletal muscle reveals exercise-induced coordinated and compartment-specific protein remodeling

This study profiles subcellular proteomes in human skeletal muscle during acute exercise and endurance training, revealing compartment-specific protein remodeling and sex-conserved responses.

Proteomic profiling of skeletal muscle ribosomes from higher versus lower responders to 10 weeks of resistance training

This study develops a ribosome enrichment protocol for human muscle tissue and examines ribosomal protein composition differences between higher and lower responders to resistance training.

Dynamic proteome profiling uncovers age-related impairments in proteostasis and the protective effects of resistance exercise in human skeletal muscle

This study uses dynamic proteome profiling to show that resistance exercise improves proteostasis in older human skeletal muscle by increasing mitochondrial protein turnover and restoring proteomic imbalances.

Stable isotope tracer captures the anabolic response of human skeletal muscle microtissues undetected by puromycin labeling

This study compares stable isotope tracers and puromycin labeling in measuring muscle protein synthesis in engineered skeletal muscle, finding tracers detect anabolic responses missed by puromycin.

Skeletal muscle proteomic responses to energy deficit with concomitant aerobic exercise in humans

This study investigates the proteomic changes in human skeletal muscle during energy deficit combined with aerobic exercise, revealing shifts toward an oxidative phenotype and metabolic adaptations.

Turnover rates of human muscle proteins in vivo reported in fractional, mole and absolute units.

The paper compares fractional, mole, and absolute turnover rates of human muscle proteins, finding that mole and absolute rates better account for abundance differences in certain contexts.

Human skeletal muscle possesses both reversible proteomic signatures and a retained proteomic memory after repeated resistance training

This study shows that resistance training induces reversible and retained proteomic changes in human skeletal muscle, suggesting a proteomic memory of muscle growth.

Endurance exercise with reduced muscle glycogen content influences substrate utilization and attenuates acute mTORC1- and autophagic signaling in human type I and type II muscle fibers

This study examines how endurance exercise with reduced muscle glycogen affects substrate utilization and signaling in human muscle fibers, finding altered fatty acid metabolism and mTORC1-autophagy dynamics.

Global Skeletal Muscle Metabolomics Reveals Mechanisms Behind Higher Response to Resistance Training in Older Adults

The paper identifies metabolic pathways disrupted in low responders to resistance training in older adults using metabolomics.

Adaptive time course of the skeletal muscle proteome during programmed resistance training in rats

This study quantifies skeletal muscle proteome changes over time in rats during resistance training, revealing distinct adaptation phases driven by ribosomal and mitochondrial protein dynamics.

Anabolic sensitivity in healthy, lean, older men is associated with higher expression of amino acid sensors and mTORC1 activators

This study shows that lean, healthy older men maintain anabolic sensitivity to amino acids and exercise, with increased mTORC1 signaling and muscle protein synthesis, suggesting aging alone does not cause anabolic resistance.

Skeletal muscle myosin heavy chain protein fragmentation as a potential marker of protein degradation in response to resistance training and disuse atrophy

This study examines how resistance exercise and disuse atrophy affect myosin heavy chain (MyHC) protein fragmentation in humans, finding increased fragmentation post-exercise and during atrophy, with adaptive responses after training.

Relative rDNA copy number is not associated with resistance training-induced skeletal muscle hypertrophy and does not affect myotube anabolism in vitro

This study investigates the relationship between relative rDNA copy number and resistance training-induced skeletal muscle hypertrophy, finding no significant association.

Kinetic modeling of leucine-mediated signaling and protein metabolism in human skeletal muscle

The paper develops a kinetic model of leucine-mediated mTOR signaling and protein metabolism in human skeletal muscle, showing that basal p70S6K levels determine MPS and insulin signaling affects net protein balance.