Salivary Gland Disorders and Functions

Interferon-α-Driven Stratification of B Cell Reveals Metabolic Reprogramming of Double Negative, Naive and Transitional cell subsets and Refines Molecular Classification in Söjgren's Disease.

This paper identifies an IFN-α signature in B cells of Sjögren's disease patients, revealing metabolic reprogramming and refining molecular classification.

The SjD Map: An interactive pathway tour into Sjogren's disease signalling mechanisms

The paper develops a molecular interaction map of Sjogren's disease using transcriptomic data and literature, integrating pathway analysis and experimental data for therapeutic insights.

Spatial transcriptomic profiling identifies lacrimal gland epithelial cell-driven mechanisms underlying autoimmunity in Sjogrens disease.

This study uses spatial transcriptomics to identify epithelial cell-driven mechanisms in Sjogrens disease, revealing new insights into autoimmune pathology and potential therapeutic targets.

Mitochondrial Dysfunction and Fatigue in Sjögren's Disease

This study investigates mitochondrial dysfunction and its link to fatigue in Sjögren's disease by analyzing T cell metabolism and mitophagy transcriptional signatures.

Serum and Tear Autoantibodies from NOD and NOR Mice as Potential Diagnostic Indicators of Local and Systemic Inflammation in Sjögren's Disease

This study identifies distinct autoantibody profiles in tears and serum from NOD and NOR mice with Sjögren's disease-associated dacryoadenitis, highlighting tear IgA diversity and TLS as a potential source.

SARS-CoV-2 Infection of Salivary Glands Compromises Oral Antifungal InnateImmunity and Predisposes to Oral Candidiasis

This study shows SARS-CoV-2 infection reduces histatin-5 in salivary glands, impairing antifungal immunity and increasing Candida albicans prevalence in COVID-19 patients.

Machine Learning Approach to Single Cell Transcriptomic Analysis of Sjogren's Disease Reveals Altered Activation States of B and T Lymphocytes

This study uses single-cell transcriptomics to identify altered activation states of B and T lymphocytes in Sjogren's Disease patients compared to controls.

Longitudinal Saliva Omics Responses to Immune Perturbation: A Case Study

This study tracks saliva omics changes over time in response to immune perturbation, revealing broad immune responses in both innate and adaptive timeframes.

Functional specialization of human salivary glands and origins of proteins intrinsic to human saliva

The paper identifies the origins of salivary proteins and reveals gene repertoires specific to fetal and adult salivary glands, showing functional diversity is driven by transcriptional regulators.