Metal-Catalyzed Oxygenation Mechanisms

Unexpected Activities of CYP152 Peroxygenases towards Non-carboxylic Substrates Reveal Novel Substrate Recognition Mechanism and Catalytic Versatility

This study reveals that CYP152 peroxygenases can degrade aromatic pollutants without a carboxyl group, showing new substrate recognition and catalytic mechanisms.

Reactive oxygen generation by minimal copper binding peptide motifs

This study identifies a minimal histidine-rich peptide motif capable of generating reactive oxygen species through copper coordination, suggesting broader implications for intrinsically disordered proteins.

The role of Tyr34 in proton-coupled electron transfer of human manganese superoxide dismutase

This study investigates the role of Tyr34 in MnSOD catalysis using neutron diffraction, X-ray spectroscopy, and quantum chemistry calculations, revealing its impact on proton-coupled electron transfer.

Unravelling an Efficient O2/Reductant-Dependent Catalytic Route in Heme Peroxygenases for Sustainable Applications

This paper identifies an O2/reductant-dependent catalytic pathway in heme peroxygenases that avoids H2O2-induced inactivation, enabling efficient and sustainable chemical transformations.

Heartbeat-like dynamics drives oxygen activation in methane monooxygenase

This paper presents a 2.85 Å cryo-EM structure of MMOH-MMOB, revealing conformational changes and Fe-Fe distances critical for oxygen activation in methane monooxygenase.

Sequential oxidation of L-lysine by a non-heme iron hydroxylase

The paper demonstrates sequential oxidation of L-lysine by a non-heme iron hydroxylase and computationally analyzes structural elements that enable this reactivity.

Double crossed? Structural and computational studies of an unusual crosslinked heme in Methylococcus capsulatus cytochrome P460

This study identifies a double crosslink between lysine and heme in Methylococcus capsulatus cytochrome P460 using structural biology and QM/MM simulations.

2.6-A resolution cryo-EM structure of a class Ia ribonucleotide reductase trapped with mechanism-based inhibitor N3CDP

This paper presents a 2.6-A resolution cryo-EM structure of E. coli class Ia RNR trapped with inhibitor N3CDP, revealing details of radical transfer and PCET mechanism.

Comparative analysis of uncoupled succinate production by the FeII/2-oxoglutarate-dependent dioxygenases

The paper measures succinate production from uncoupled 2OG decarboxylation by FeII/2OG-dependent dioxygenases and validates ALKBH6 functionality.