Rabies epidemiology and control

A randomized controlled trial of the effectiveness of a community-based rabies vaccination strategy

This paper compares community-based and team-based dog vaccination strategies, finding community-based delivery achieves higher and more consistent coverage, exceeding the critical threshold for herd immunity.

Antigenic landscape of rabies and related lyssaviruses revealed by cryo-EM

The paper determines cryo-EM structures of monoclonal antibodies bound to rabies virus glycoprotein, identifying new antigenic sites and their role in neutralization.

Application of the CPER reverse genetics system for genetic engineering of rabies virus

This paper develops a CPER-based reverse genetics system for rabies virus, enabling the generation of recombinant viruses with various genetic modifications.

Changes in free-roaming dog population demographics and health associated with a catch-neuter-vaccinate-release program in Jamshedpur, India

This study evaluates the impact of a CNVR program on free-roaming dog demographics and health in Jamshedpur, India, finding reduced prevalence of certain health issues and increased sterilization rates in treated areas.

Human brain cell types shape host-rabies virus transcriptional interactions revealing a preexisting pro-viral astrocyte subpopulation

The paper investigates how rabies virus interacts with different human brain cell types, identifying a pro-viral astrocyte subpopulation that enhances viral transcription.

Estimation of free-roaming dog populations using Google Street View: A Validation Study

This study validates using Google Street View imagery with citizen scientists to estimate free-roaming dog populations in urban areas, finding a strong correlation with door-to-door surveys.

Large circulation of a novel vesiculovirus in bats in the Mediterranean region

The paper identifies a novel vesiculovirus, Mediterranean bat virus (MBV), circulating in bats across the Mediterranean region using a new RT-qPCR method and genomic analysis.

Deep mutational scanning of rabies glycoprotein defines mutational constraint and antibody-escape mutations

This study uses deep mutational scanning to identify functional and antigenic effects of mutations in rabies glycoprotein, revealing escape mutations for antibodies and constrained regions for vaccine development.

Reducing spatial heterogeneity in coverage improves the effectiveness of dog vaccination campaigns against rabies

This study shows that reducing spatial heterogeneity in dog vaccination coverage improves rabies control in Serengeti, Tanzania, by decreasing focal incidence and preventing outbreaks.

Genomic Characterization of a Dog-Mediated Rabies Outbreak in El Pedregal, Arequipa, Peru

This study sequenced rabies virus genomes from a dog-mediated outbreak in El Pedregal, Peru, revealing multiple introductions and linking them to ongoing rabies circulation in Arequipa and Bolivia.

Immunogenicity of Rabies Virus G-Protein mRNA Formulated with Muscle Targeting Lipid Nanoparticles in Mice

This study evaluates an mRNA vaccine encoding the Rabies Virus G-protein formulated with muscle-targeting lipid nanoparticles, showing high immunogenicity and protection in mice.

Immunological findings of West Caucasian bat virus in an accidental host

This study investigates the immune response to West Caucasian bat virus (WCBV) in Syrian hamsters, finding it induces an intermediate antiviral response compared to Rabies and Duvenhage viruses.

Structural insight into rabies virus neutralization revealed by an engineered antibody scaffold

This paper determines the crystal structure of an engineered antibody diabody bound to rabies virus glycoprotein, revealing a conserved epitope and mechanism of neutralization.

Making Genomic Surveillance Deliver: A Lineage Classification and Nomenclature System to Inform Rabies Virus Elimination

This paper introduces a lineage classification system for rabies virus based on SARS-CoV-2 nomenclature, enabling high-resolution tracking of viral spread and improving disease control.

Intracerebral transfection of anti-rabies virus antibodies is an effective therapy for rabies

This study shows that intracerebral transfection of anti-rabies virus antibodies reduces morbidity/mortality in mice infected with rabies virus.