Spaceflight effects on biology

Genetic Variability affects the Skeletal Response to Unloading

The paper shows genetic differences affect bone loss in mice under unloading, with specific strains showing greater bone volume and strength loss.

Transcriptomic analysis of DNA damage response in zebrafish embryos under simulated microgravity

The paper examines the impact of simulated microgravity on DNA damage response in zebrafish embryos and compares it to human spaceflight effects observed in the NASA twin study.

GraviKit: an easy-to-implement microscope add-on for observation of gravitation dependent processes

GraviKit enables gravity-dependent imaging with a horizontal beampath by converting standard microscopes into devices with a rotatable stage.

MRI-Visible Perivascular Space (PVS) Changes with Long-Duration Spaceflight

This study examines how spaceflight affects MRI-visible perivascular spaces (PVSs) in astronauts, finding that novice astronauts show increased PVS volume post-flight, while experienced astronauts show baseline correlations between flight days and PVS length.

Ophthalmic Changes in a Spaceflight Analog Are Associated with Brain Functional Reorganization

This study examines resting-state functional connectivity changes in a spaceflight analog, finding distinct patterns in those who develop optic disc edema compared to those who do not.

Alternative Splicing Regulates the Physiological Adaptation of the Mouse Hind Limb Postural and Phasic Muscles to Microgravity

This study investigates how alternative splicing and differential gene expression contribute to muscle adaptation to microgravity in mice, finding that AS plays a major role in transcriptomic changes.

Spaceflight decelerates the epigenetic clock orchestrated with a global alteration in DNA methylome and transcriptome in the mouse retina

This study shows spaceflight alters the DNA methylome and transcriptome in mouse retinas, slowing the epigenetic clock and affecting disease-related pathways.

Spaceflight Affects Neuronal Morphology and Alters Transcellular Degradation of Neuronal Debris in Adult Caenorhabditis elegans

This study shows that spaceflight causes dendritic remodeling and impaired clearance of neuronal debris in adult C. elegans neurons.

Brain Connectivity and Behavioral Changes in aSpaceflight Analog Environment with Elevated CO2

This study examines how a spaceflight analog environment with elevated CO2 affects brain connectivity and sensorimotor performance over time.

Multi-domain cognitive assessment of male mice reveals whole body exposure to space radiation is not detrimental to high-level cognition and actually improves pattern separation.

The paper exposes male mice to space radiation and finds no detrimental effect on high-level cognition, with improved pattern separation performance.

A synthetic biochemical device for sensing microgravity

The paper introduces a synthetic RNA-based microgravity sensor in E. coli that alters target protein expression in response to microgravity, demonstrating its potential for space biotechnology applications.

RNAseq analysis of rodent spaceflight experiments is confounded by sample collection techniques

The paper shows that RNAseq analysis of rodent spaceflight experiments is confounded by sample collection and preservation techniques, with preservation effects overshadowing spaceflight effects.

Selective facilitation of egocentric mental transformations under short-term microgravity

This study investigates how microgravity affects perspective-taking abilities, finding it selectively enhances mental rotations in the frontal plane and varies by visual field dependence.

Caenorhabditis elegans Exhibits Positive Gravitaxis

This study shows that Caenorhabditis elegans senses and responds to gravity through an active behavior requiring gravisensation, with gravity response declining with age.

Comparative Transcriptomic Signature of the Simulated Microgravity Response in Caenorhabditis elegans

This study identifies the transcriptomic response of C. elegans to simulated microgravity and shows that 75% of gene expression changes persist for four days post-exposure.