T-cell and Retrovirus Studies

Multiple Pol determinants constrain koala retrovirus A replication

This study identifies PR, RT, and cleavage-site interactions as determinants of KoRV-A replication efficiency and reveals unusual extracellular particle organization.

Transcriptional rewiring of NF-κB by HBZ and Fra-2 drives inflammatory chemoresistance in Tax-negative adult T-cell leukemia/lymphoma

This study identifies the Fra-2-NF-κB-IL-1β axis as a mechanism driving chemoresistance in Tax-negative ATL, with therapeutic targeting of IL-1 signaling restoring drug sensitivity.

A Living Oncogenic Microcell Isolated from Mammalian Cancers

The paper isolates and characterizes microcellular organisms from mammalian cancers, showing they have RNA-based genetics, reverse transcriptase activity, and oncogenic potential.

Quantification of STLV-1 Tax in various tissues of non-human primates by different PCR methods.

This study quantifies STLV-1 Tax in tissues of non-human primates using TaqMan qPCR and ddPCR, finding higher detection in stomach compared to tonsils.

Antagonistic regulation of HBZ splicing by hnRNPA1 and hnRNPH1 drives HTLV-1 leukemogenesis.

This paper identifies HBZ splicing regulation by hnRNPA1 and hnRNPH1 as a key driver of HTLV-1 leukemogenesis, showing that HBZ_SP1 promotes transformation and chemoresistance in ATL.

Seroprevalence of Human T-Lymphotropic Virus Type-1 (HTLV-1) Among Blood Donors at a Tertiary Hospital in Abakaliki, Ebonyi State, Nigeria

The study assesses HTLV-1 seroprevalence among blood donors in Nigeria, finding 24.6% positivity with higher rates in specific age, marital status, and occupational groups.

HTLV-1 intasome recruits the PP2A-B56 holoenzyme and restricts its phosphatase activity

The paper shows HTLV-1 integrase recruits PP2A-B56 holoenzyme, structurally inhibiting its phosphatase activity without affecting infection.

HTLV-1-Induced Neuroimmunome Correlates with Disease Progression and Severity

The paper identifies a neuroimmune signature in HTLV-1 infection that correlates with disease progression and severity using bulk and single-cell transcriptomic data.

FDXR Upregulation by p63/p73 is a Prognostic and Therapeutic Marker of HTLV-1-Associated Adult T Cell Leukemia/Lymphoma

This study identifies FDXR upregulation as a prognostic marker and therapeutic target in HTLV-1-associated ATL, showing its link to disease severity and sensitivity to fluorouracil.

Feline leukaemia virus subgrouping using the viral interference assay

This study investigates FeLV subgroup detection using interference assays in 50 cases, finding co-infection with FeLV-A and FeLV-B in 62% of cases.

Human RPL7 and DDX21 interact with HTLV-1 Gag and enhance tRNAPro primer annealing to genomic RNA

This study identifies RPL7 and DDX21 as co-chaperones that enhance HTLV-1 Gag's ability to anneal tRNAPro to the viral genomic RNA primer binding site.

Machine Learning-based Identification and Characterization of High-risk Carriers of HTLV-1-Associated Myelopathy (HAM)

This study uses machine learning to identify high-risk HTLV-1 carriers likely to develop HAM by analyzing proviral load and antibody titers.

HTLV-1 Tax induces PINK1-Parkin-dependent mitophagy to mitigate activation of the cGAS-STING pathway

This study shows HTLV-1 Tax induces mitophagy via PINK1-Parkin to suppress cGAS-STING activation and type I IFN, aiding viral persistence and cell survival.

Bioinformatic analysis of the variability of Tax1 and Tax2 proteins of the human T-cell lymphotropic virus (HTLV)

The paper uses bioinformatics tools to analyze the conservation and variability of Tax1 and Tax2 proteins from HTLV-1 and HTLV-2, highlighting sequence differences that may explain functional differences in pathogenicity.

Unconventional stabilization of the human T-cell leukemia virus type 1 immature Gag lattice

This paper identifies an unconventional stabilization mechanism in HTLV-1 immature Gag lattice using cryo-ET and mutagenesis, showing CA-NTD as the primary stabilizing component.

Implication of the cellular factor CTCF in the regulation of Bovine Leukemia Virus latency and tridimensional chromatin organization

This study shows CTCF regulates BLV transcription and 3D chromatin structure, affecting viral latency and host cell organization.