Genetics and Physical Performance

Association between KCNC1 gene polymorphism and blood lipid levels in determining the efficacy of high-intensity interval training

This study examines how KCNC1 gene polymorphisms affect blood lipid levels and response to high-intensity interval training in young Han Chinese individuals, finding sex-specific associations.

Skeletal muscle enhancer programming of intrinsic cardiorespiratory fitness

The paper identifies enhancer architecture differences in skeletal muscle between high and low cardiorespiratory fitness rats, linking them to gene expression and metabolic traits.

Polygenic prediction of cardiorespiratory fitness: The HUNT Study

This study develops and validates a polygenic score for cardiorespiratory fitness (CRF) and finds it is associated with reduced cardiovascular disease and mortality risks.

R allele of ACTN3 R577X gene polymorphism is associated with Elite Indian Boxer Status

The paper examines the association between ACTN3 R577X polymorphism and elite boxer status in the Indian population, finding higher R allele frequency in boxers compared to nonathletes.

alpha-Actinin-3 deficiency protects from the effects of acute cold exposure through altered skeletal muscle Ca2+ and OXPHOS signaling.

This study shows that alpha-actinin-3 deficiency improves cold tolerance through enhanced mitochondrial function and reduced muscle mass loss during acute cold exposure.

Molecular Landscape of Modality-Specific Exercise Adaptation in Human Skeletal Muscle through Large-Scale Multi-OMICs Integration

This study integrates multi-OMIC data from 12 cohorts to identify exercise-specific molecular signatures and gene regulatory patterns in human skeletal muscle.

ACTN3 genotype influences androgen response in skeletal muscle

This study shows that ACTN3 genotype affects androgen response in skeletal muscle by altering AR expression and pathways related to muscle homeostasis.

It All Rolls Downstream: Upstream Control of Physical Activity Regulation

This study identifies upstream regulators of physical activity by analyzing genetic molecules associated with activity regulation, finding beta-estradiol as a key regulator in both brain and muscle datasets.

Relationship between the ACTN3, ACE, AGT, BDKRB2 and IL6 genes and the intake of creatine HCl, whey protein and glutamine, with changes in strength and fat percentage, before an undulating strength program in lower limbs in athletes from Valle del Cauca. Colombia

The study examines how sports supplements affect strength and body composition in athletes with specific genotypes, finding greater gains in supplemented athletes with lower TGS.

The association of catechol-O-methyltransferase genetic polymorphism rs4680 in physical activity among adult women

The paper investigates the association between COMT rs4680 polymorphism and physical activity levels in middle-aged women, finding higher prevalence of the A-allele among highly active individuals.

Genotypic and allelic distribution of the ACE, ACTN3, and IL6 genes in athletes of Artistic Gymnastics and Swimming in the department of Norte de Santander, Colombia

The paper reports allelic and genotypic frequencies of ACE, ACTN3, and IL6 genes in Colombian athletes of artistic gymnastics and swimming, finding significant differences in ACTN3 but not in ACE or IL6 between the sports.

Association of variants in ACE, ACTN3, AGT, IL6 and BDKRB2 genes with athlete status and playing position in Colombian amateur rugby athletes

Identification of novel mitochondrial and mitochondrial related genetic loci associated with exercise response in the Gene SMART study

The paper identifies nine nuclear-encoded SNPs associated with exercise response in the Gene SMART cohort using whole-mitochondrial genome sequencing and composite trait analysis.

How do your genetics compare to the world’s elite marathoners?

The paper identifies genetic traits linked to endurance, anxiety, and injury risk in elite marathoners and compares them to a normal population using AI.

Relationship between ACTN3 and ACE polymorphisms and FIFA World averaged rating.

The paper examines the relationship between ACTN3 and ACE gene polymorphism frequencies and FIFA World Average Rating, finding that these frequencies are associated with FWAR entropy.

A genetic-based algorithm for recovery: A pilot study

This study shows that genetic variants linked to reduced exercise recovery are associated with greater decreases in countermovement jump height after training in soccer players.