Genetics and Physical Performance

Evaluating a Genome-Wide Polygenic Score for Handgrip Strength and Its Interplay with Leisure-Time Physical Activity Across the IGEMS Twin Cohorts

The paper evaluates a polygenic score for handgrip strength and its interaction with physical activity across twin cohorts, finding a significant genetic association and effect modification by physical activity.

Association between KCNC1 gene polymorphism and blood lipid levels in determining the efficacy of high-intensity interval training

This study examines how KCNC1 gene polymorphisms affect blood lipid levels and response to high-intensity interval training in young Han Chinese individuals, finding sex-specific associations.

Skeletal muscle enhancer programming of intrinsic cardiorespiratory fitness

The paper identifies enhancer architecture differences in skeletal muscle between high and low cardiorespiratory fitness rats, linking them to gene expression and metabolic traits.

A contextual genomic perspective on physical activity and its relationship to health, well-being and illness

This study investigates the genetic basis of physical activity across different contexts and finds that leisure-time activity has distinct genetic influences and protective health effects.

Polygenic prediction of cardiorespiratory fitness: The HUNT Study

This study develops and validates a polygenic score for cardiorespiratory fitness (CRF) and finds it is associated with reduced cardiovascular disease and mortality risks.

R allele of ACTN3 R577X gene polymorphism is associated with Elite Indian Boxer Status

The paper examines the association between ACTN3 R577X polymorphism and elite boxer status in the Indian population, finding higher R allele frequency in boxers compared to nonathletes.

alpha-Actinin-3 deficiency protects from the effects of acute cold exposure through altered skeletal muscle Ca2+ and OXPHOS signaling.

This study shows that alpha-actinin-3 deficiency improves cold tolerance through enhanced mitochondrial function and reduced muscle mass loss during acute cold exposure.

Molecular Landscape of Modality-Specific Exercise Adaptation in Human Skeletal Muscle through Large-Scale Multi-OMICs Integration

This study integrates multi-OMIC data from 12 cohorts to identify exercise-specific molecular signatures and gene regulatory patterns in human skeletal muscle.

ACTN3 genotype influences androgen response in skeletal muscle

This study shows that ACTN3 genotype affects androgen response in skeletal muscle by altering AR expression and pathways related to muscle homeostasis.

It All Rolls Downstream: Upstream Control of Physical Activity Regulation

This study identifies upstream regulators of physical activity by analyzing genetic molecules associated with activity regulation, finding beta-estradiol as a key regulator in both brain and muscle datasets.

Relationship between the ACTN3, ACE, AGT, BDKRB2 and IL6 genes and the intake of creatine HCl, whey protein and glutamine, with changes in strength and fat percentage, before an undulating strength program in lower limbs in athletes from Valle del Cauca. Colombia

The study examines how sports supplements affect strength and body composition in athletes with specific genotypes, finding greater gains in supplemented athletes with lower TGS.

Genome-wide association study of liking of physical activity in the UK Biobank

This study identifies 19 genome-wide significant loci associated with liking of physical activity traits using UK Biobank data and validates findings in twin cohorts.

The association of catechol-O-methyltransferase genetic polymorphism rs4680 in physical activity among adult women

The paper investigates the association between COMT rs4680 polymorphism and physical activity levels in middle-aged women, finding higher prevalence of the A-allele among highly active individuals.

Genotypic and allelic distribution of the ACE, ACTN3, and IL6 genes in athletes of Artistic Gymnastics and Swimming in the department of Norte de Santander, Colombia

The paper reports allelic and genotypic frequencies of ACE, ACTN3, and IL6 genes in Colombian athletes of artistic gymnastics and swimming, finding significant differences in ACTN3 but not in ACE or IL6 between the sports.

Association of variants in ACE, ACTN3, AGT, IL6 and BDKRB2 genes with athlete status and playing position in Colombian amateur rugby athletes

The genetic case for cardiorespiratory fitness as a clinical vital sign and the routine prescription of physical activity in healthcare

This paper uses genetic data to support cardiorespiratory fitness (CRF) as a clinical vital sign and advocates for routine physical activity prescription in healthcare.

Loss of α-actinin-3 during human evolution provides superior cold resilience and muscle heat generation

The paper shows that absence of α-actinin-3 in humans improves cold resilience through changes in skeletal muscle thermogenesis and myosin heavy chain composition.

Detection of epistasis between ACTN3 and SNAP-25 with an insight towards gymnastic aptitude identification

The paper identifies an epistatic interaction between ACTN3 and SNAP-25 polymorphisms that improves identification of gymnastic aptitude compared to additive models.

Identification of novel mitochondrial and mitochondrial related genetic loci associated with exercise response in the Gene SMART study

The paper identifies nine nuclear-encoded SNPs associated with exercise response in the Gene SMART cohort using whole-mitochondrial genome sequencing and composite trait analysis.

Effect of PPARGC1A Gly428Ser (rs8192678) polymorphism on athletic sports performance: A meta-analysis

This meta-analysis examines the association between PPARGC1A Gly482Ser polymorphism and athletic sports performance, finding the Gly allele significantly favors performance.

How do your genetics compare to the world’s elite marathoners?

The paper identifies genetic traits linked to endurance, anxiety, and injury risk in elite marathoners and compares them to a normal population using AI.

Relationship between ACTN3 and ACE polymorphisms and FIFA World averaged rating.

The paper examines the relationship between ACTN3 and ACE gene polymorphism frequencies and FIFA World Average Rating, finding that these frequencies are associated with FWAR entropy.

Genome-wide association study of habitual physical activity in over 277,000 UK Biobank participants identifies multiple variants including CADM2 and APOE

This study identifies 26 genetic loci associated with physical activity using UK Biobank data, including APOE and CADM2, and finds genetic correlations with educational attainment and psychiatric traits.

A genetic-based algorithm for recovery: A pilot study

This study shows that genetic variants linked to reduced exercise recovery are associated with greater decreases in countermovement jump height after training in soccer players.