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This study investigates how Plasmodium actin depolymerizing factors interact with phosphoinositides, revealing structural and functional differences between ADF1 and ADF2.

The paper develops a combined untargeted and semi-targeted metabolomics approach to profile small intestinal and fecal metabolomes, revealing distinct metabolomes and potential new bile acids.

This paper develops a method to perform single-cell proteomics on preserved tissues, expanding its applicability by overcoming sample preservation challenges.

This paper investigates how high-dose vitamin C inhibits myeloperoxidase-generated hypochlorous acid through oxidation products, suggesting potential therapeutic applications for cancer and neutrophil-related diseases.

This paper compares univariate and multivariate reference interval methods, finding that multivariate approaches reduce false positives and improve accuracy in clinical settings.

This paper presents a computational design of high-efficiency Kemp eliminases with unprecedented catalytic efficiency and stability through de novo enzyme design.

This study shows SFN-glycoconjugates reduce inflammation in dendritic cells by targeting the NF-kappaB pathway, inducing immunotolerance better than NF-kappaB inhibition alone.

The paper introduces GAP-MS to study glycan-dependent PPIs and shows it identifies PPI variations under different glycosylation conditions.

The paper reports the cryo-EM structure of a blue-shifted channelrhodopsin from Klebsormidium nitens and develops mutants with blue-shifted action spectra.

This study shows TCF4 undergoes LLPS in vitro, which is reversible and regulated by DNA binding, suggesting a role in transcriptional activation and potential involvement in neurological diseases.

The paper identifies sideroflexins as mitochondrial transporters for neutral amino acids and shows functional overlap among paralogues.

This paper designs and tests sEH-PROTACs to degrade soluble epoxide hydrolase, identifying PROTAC 23 as effective in degrading sEH in human macrophages.

This study identifies CtdA, a tRNA deacetylase that removes canavanine from mischarged tRNAArg, and reveals its structural and evolutionary relationships to B3/B4 domains.

This study shows that reduced NEU1 activity in neurological MPS leads to hypersialylation of brain glycoproteins, contributing to CNS pathology through disrupted synaptogenesis and behavior.

This paper identifies SLC35F2 as a high-specificity transporter for queuine and queuosine in multiple species and shows its role in regulating intracellular levels of these micronutrients.

This study identifies Ser/Thr phosphorylation by PknK as a novel regulatory mechanism for Type II TA modules in M. tuberculosis, disrupting toxin-antitoxin interactions.

This study identifies IP6K1 as a regulator of mitochondrial polyP synthesis and function, showing its role in energy homeostasis through 5-InsP7 production and a catalytic-independent mechanism.

This study shows that gut SQOR deficiency and high dietary methionine impair colon bioenergetics, alter microbiome, and affect brain function and behavior.

This study examines how mitochondrial outer membrane lipids affect VDAC1 assembly using atomic force microscopy and simulations, showing lipid regulation of VDAC organization.

The paper identifies toxic intermediate complexes formed during mitochondrial complex I assembly in NDUFS4 mutant mice, revealing hypoxia's role in rescuing disease by preventing pathological reverse electron transfer.