Discover, rate, and discuss biology preprints.

This study uses OCT to show the urothelium absorbs and expels water in response to NaCl, challenging its traditional view as impermeable and linking osmotic stress to urothelial damage.

This study develops and validates a TTF prototype for glioblastoma therapy, showing reduced tumor growth and increased apoptosis in vitro and in vivo.

This study investigates how low-frequency focused ultrasound affects astrocyte and neuronal calcium dynamics in mouse cortex, finding state-dependent effects with greater astrocytic response in awake mice.

This paper describes a novel fetal therapy approach using transplanted fetal kidneys from different species to provide a bridge to dialysis in affected fetuses, demonstrating successful urine production and long-term function without immunosuppressants.

This paper introduces PERC, a method for efficient CRISPR editing in primary human immune cells and HSPCs using a peptide reagent, achieving over 90% editing efficiency without specialized equipment.

This study shows prolonged shear stress induces fibroblast-to-myofibroblast transition through mechanical and biochemical changes, with lasting effects on cell morphology, adhesion, and migration.

This paper develops micrometer-scale tPA beads that enhance plasmin generation and fibrinolysis, achieving rapid thrombus removal in a mouse stroke model with lower doses than standard tPA.

This study shows that Drosophila adjusts flight speed through adaptive feedforward control, not just feedback, by observing changes in speed after wing damage and antennae ablation.

This study investigates how EDA fibronectin matrix organization during wound closure influences YAP translocation, showing that altered matrix structure in fibrotic wounds disrupts YAP signaling, potentially impairing regenerative repair.

The paper compares the morphology of astrocytes in the lamina cribrosa and glial lamina across species to understand their role in glaucoma.

BOOST is a rapid expansion microscopy method that achieves ~10x linear expansion in 90 minutes using microwave-assisted chemistry, improving throughput for various biological specimens.

This study shows that tissue-engineered heart valves with native biaxial mechanical properties perform better and avoid fibrosis compared to those with non-physiological mechanics.

Portable therapeutic ultrasound enhanced AAV9 delivery to the brain in mice and rhesus macaques compared to systemic injection alone.

This paper demonstrates a microfluidic cross-slot device to measure linear viscoelastic properties of microparticles by replicating uniaxial creep tests at high throughput.

This paper estimates speech-reception-threshold using EEG-based envelope reconstruction and analyzes how SNR affects TRF components, showing strong alignment between neurophysiological and behavioral measures.

This study uses light-controlled EGF receptors to precisely manipulate tissue movements in epithelial cells, showing light can drive millimeter-scale rearrangements.

This study develops scalable methods to produce and purify engineered ARRDC1-mediated microvesicles (ARMMs) for gene therapy delivery, showing efficient production and in vivo biodistribution.

This study shows that cell-scale porosity in MAP scaffolds improves muscle regeneration in VML injuries by modulating immune response and supporting innervated muscle fiber formation.

This study develops a 3D tissue platform with collagen and stem cells to screen cell-cell and cell-matrix interactions, showing enhanced vascularization and identifying pathways affecting vasculogenesis and ASD models.

PHIROS enables long-term, high-resolution imaging of organotypic brain slices with controlled perfusion, revealing dynamic tumor-astrocyte interactions and mitochondrial transfer.