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CRADLE: A Clinically Robust, Anatomy-Aware Post-Processing Framework for Infant GMA Landmark Tracking in 2D Videos

CRADLE improves 2D infant movement tracking by refining landmark positions using anatomical constraints and filtering, reducing errors at distal joints.

Correlating amino acid profiles with improved expression capability of superior CHO based expression platforms

The paper constructs a modified CHO cell line to improve Rituximab expression and uses amino acid analysis to assess cellular health and stress response.

A Comprehensive Computational Model of the Human head for Designing and Optimizing Visual Brain-Machine Interfaces

The paper develops a comprehensive computational model of the human head to optimize visual brain-machine interfaces by simulating the entire visual pathway and surrounding tissues.

From Spectra to Digital Phenotypes: Wearable Multispectral Sensing for Precision Light and Green Space Exposure

This paper introduces SpectraVita, a wearable device that measures multispectral light and green space exposure, achieving high accuracy in classification and detection.

Structure-Property-Performance Engineering of Hydrogel Depots for Long-Acting Peptide Delivery

This paper develops a hydrogel depot system for long-acting peptide delivery, showing sustained release and improved therapeutic outcomes in rodents.

ReMind: A Retrospective Self-Report Paradigm for Studying Mind-Wandering Onset During Reading

ReMind estimates mind-wandering onset during reading by combining retrospective self-reports with eye-tracking, showing improved detection using onset-aligned windows.

Frequency-Dependent Bioimpedance Signatures of Ocular Tissues in Intact Ex Vivo Eyes Under Simulated Surgical Conditions

This study measures frequency-dependent bioimpedance of ocular tissues in ex vivo porcine eyes and shows significant tissue separability at specific frequencies.

Rapid imaging of lysyl oxidase activity and fibrogenesis with a turn-on fluorophore

This paper introduces a fluorescent staining method to visualize LOX activity and fibrogenesis in tissue sections using a turn-on fluorophore, validated in mouse and human samples.

Proteomic analysis reveals regional sex differences in healthy and fibrotic human lung

This study identifies sex-biased protein expression in healthy and fibrotic human lung regions, highlighting potential biological mechanisms for sex differences in idiopathic pulmonary fibrosis.

Comparison of Osteoblast Calcification in Bio-Oss, Cerasorb, Pro Osteon, and Bio-Tiss Cerabone

This study compares the osteogenic potential of four bone graft biomaterials using in vitro assays, finding that Bio-Oss and Cerasorb outperformed Pro Osteon and Bio-Tiss Cerabone in gene expression, ALP activity, and mineralization.

Structural dynamics insights into principles underlying the fitness of new broadly potent AAVs

The paper develops a new AAV engineering workflow, scAAVengr-Hunt, to create potent vectors and identifies a structural mechanism underlying their broad species and tissue potency.

Fibronectin and laminin differentially affect the inflammatory environment in microphysiological systems

This study investigates how fibronectin and laminin affect the inflammatory environment in 3D engineered constructs using an inflammation-on-a-chip device.

Machine Learning-Driven Optimization of Specific, Compact, and Efficient Base Editors via Single-Round Diversification

This paper develops novel base editors by diversifying TadA orthologs and using generative models to optimize specificity and efficiency.

Characterization of calcifications in posterior horn of human meniscus using micro-computed tomography

This study uses micro-CT to identify and quantify differences in calcification patterns between basic calcium phosphate and calcium pyrophosphate in human meniscus, providing insights into their roles in osteoarthritis.

Green genetically encoded IP3 biosensor for hierarchical analysis of its signaling network

The paper develops a genetically encoded green fluorescent IP3 biosensor for detecting IP3 signals across concentrations and visualizing its signaling network with cAMP and Ca2+.

Chloroplast genome engineering of potato enables diterpene production without agronomic penalty

This study engineering potato chloroplast genomes to produce diterpenes without agronomic penalties by optimizing gene insertion and precursor supply.

Cell-scale autonomous CMOS motes for intracellular bioelectronics

The paper introduces cell-scale CMOS motes powered optically for intracellular bioelectronics, demonstrating their ability to operate within single-celled organisms with minimal cytoplasmic displacement.

Epicardial extracellular vesicles modulate gene expression following ischemia-reperfusion injury in heart-on-a-chip

The paper investigates how epicardial extracellular vesicles affect gene expression during ischemia-reperfusion injury using a heart-on-a-chip model.

Machine Learning-assisted Raman Spectral Analysis of Serotonin-responsive ssDNA-SWCNT Nanosensor for Improved Selectivity against Dopamine

This paper improves the selectivity of a serotonin-sensitive nanosensor using machine learning and Raman spectroscopy to distinguish serotonin from dopamine.

Targeted Magnetic Nanodiscs for Wireless Causal Manipulation of Gut-Brain Circuits

This paper develops magnetic nanodiscs for wireless, cell-type specific activation of gut-brain circuits, showing they can regulate feeding behavior through hindbrain satiety circuits.