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Membrane sialylation orchestrates cellular gateways: A spatiotemporal analysis of cellular transport using DNA nanocages via membrane charge modulation

The paper shows that increased cell surface sialylation enhances DNA nanocage uptake by remodeling the membrane and recruiting caveolae-mediated endocytosis in RPE1 cells.

Mechanical Fingerprints in Breast Cancer Research: A Multimodal Experimental Approach

This study develops a multimodal biomechanical platform to measure and compare viscoelastic properties of healthy and tumoral breast tissues, revealing mechanical differences linked to therapy resistance.

Unlocking the potential of Gordonia rubripertincta in syngas fermentation for carbon monoxide bioconversion into carotenoids

This paper investigates the use of Gordonia rubripertincta for syngas fermentation to produce carotenoids, finding optimal conditions for carotenoid yield.

Implementation of an adaptive-optics assisted isoSTED nanoscope

This paper describes the construction and alignment of an adaptive-optics assisted isoSTED nanoscope for achieving isotropic sub-50-nm 3D resolution in thick biological samples.

Parallel Activation and Interference CRISPR (PAIR) with Sequencing Uncovers DNA Repair Networks Guiding Precision Cell Engineering

PAIR combines CRISPR activation and RNA knockdown to study bidirectional gene interactions in DNA repair, revealing strategies to enhance CRISPR-based gene editing precision.

Zero-Shot Design of a Biobetter Cetuximab: Enhanced EGFR Affinity with Preserved Developability

The paper designs a biobetter version of cetuximab with enhanced EGFR affinity using ConvergeAB, showing improved binding without compromising developability.

Towards Continuous Home Monitoring for Dementia: A Real-Time mmWave Radar Framework for Activity Classification and Tracking

This paper introduces a real-time mmWave radar framework for activity classification and tracking in dementia home monitoring, achieving high accuracy in detecting stationary, walking, and absent states.

Reducing encapsidated impurity DNA derived from plasmid backbone by modifying the p5 terminal resolution site in rAAV vector production

This study modifies the p5 terminal resolution site in AAV vectors to reduce encapsidated plasmid backbone DNA, improving vector safety and yield.

Thermal Conductivity of Artificial Materials Engineered from Plant and Bacterial Cells

This study evaluates the thermal conductivity of plant and bacterial cells as potential biodegradable thermal insulation materials, finding low thermal conductivity and stable performance.

Relief of allosteric inhibition, redox imbalance, and transport limitations enables high-yield L-malate production in Escherichia coli

This study improves an Escherichia coli strain for high-yield L-malate production by modifying allosteric regulation, redox balance, and transport, achieving a mass yield of 1.2 g malate per gram of glucose.

Genuine Directed Evolution In Test Tube (GENie)

The paper introduces a test-tube directed evolution platform that enables high-throughput screening without specialized equipment, achieving significant enzyme improvement in catalytic efficiency.

Adhesive silk hydrogel patches for localized and sustained delivery of cell-derived nanovesicles

This paper develops an adhesive silk hydrogel patch for localized and sustained delivery of stem cell-derived nanovesicles, showing anti-fibrotic effects in vitro and in a mouse model.

Electrical stimulation precisely reproduces naturalistic spiking activity in complete and intermixed neural populations in the primate retina

This study uses electrical stimulation to replicate natural spiking activity in primate retinal neurons, achieving lower variability than visual stimuli.

Design of a Conductive Hydrogel Coating to Improve Catheter-Tissue Coupling in Radiofrequency Ablation

This study develops a conductive hydrogel coating for radiofrequency ablation catheters to improve tissue contact and energy transfer, reducing collateral damage and recurrence.

Fast Dynamic Whole-Body In Vivo Cytometry Using Magnetic Particle Imaging

This study uses magnetic particle imaging to dynamically track and quantify therapeutic stem cell accumulation in vivo.

Formulation Development of Topical Inserts Containing Doxycycline and Doxycycline Combined with Tenofovir Alafenamide and Elvitegravir for the Prevention of Sexually Transmitted Infections

This paper develops single and combined topical inserts for bacterial STI and HIV prevention, showing effective drug release and stability.

Development of a Synthetic Hydrogel to Foster Microvascularization of an Endometriosis Microphysiological System

This paper develops a synthetic hydrogel that enables microvascularization in a microphysiological system for endometriosis research, improving reproducibility and biological fidelity.

Chemical Stimulation Sustains Bioluminescence of Living Light Materials

This paper develops a chemical stimulation method to sustain bioluminescence in living materials made from Pyrocystis lunula, enabling long-term, responsive light emission.

Gradient Multinozzle 3D Printing

The paper introduces GEM multinozzle printheads to accelerate ink formulation by enabling parallelized printing and combinatorial ink mixing for complex 3D structures.

An agent-based model suggests how senescent cell behavior and matrix mechanics drive pulmonary fibrosis in aged mice

The paper develops an agent-based model to show how senescent cell behavior and tissue mechanics contribute to pulmonary fibrosis in aged mice.