Discover, rate, and discuss biology preprints.

The paper develops a Bayesian statistical framework to predict single-cell age from transcriptomic profiles and demonstrates its accuracy on Tabula Muris Senis data.

This study finds that autistic traits are linked to a suboptimal decision bias strategy in subsecond timing tasks, not reduced perceptual sensitivity.

This study uses single-cell RNA-seq to analyze transcriptional changes in mouse hearts during perinatal development, identifying gene regulatory patterns and a cell type-independent imprinted gene signature.

This study shows that manipulating cellular aging in larval Drosophila midgut progenitors affects long-term intestinal aging and homeostasis in adults.

This study demonstrates the feasibility of establishing an ex vivo human growth plate model using tissue from percutaneous epiphysiodesis procedures to study bone growth and pediatric growth disorders.

The paper identifies a developmentally regulated long-range enhancer-promoter contact that is critical for SOX2 expression and neuroectodermal differentiation in human neural development.

This paper describes the embryonic development of the convict cichlid from fertilization to hatching, providing a staging table for comparative developmental studies.

This paper refines an in vitro protocol for culturing schistosomes to achieve sexual dimorphism, showing that human serum promotes red blood cell digestion and sexual differentiation compared to fetal bovine serum.

This study finds that neonatal resting-state EEG aperiodic activity relates to 12-month communicative abilities in typically developing infants, showing an inverted U-shaped relationship.

This study shows Notch signalling regulates human ENS progenitor dynamics, affecting differentiation and migration, and links its disruption to intestinal aganglionosis.

This study demonstrates that AAV-DJ efficiently and safely transduces human ovarian cells, enabling targeted gene modulation with significant knockdown of AMHR2 and TGF{beta}1.

The paper shows that cell size can override fate determinants in Drosophila neuroblasts, with larger daughters retaining neuroblast-like properties despite inheriting GMC determinants.

The paper shows how coordinated Wnt and Hedgehog signaling creates sharp cell-type boundaries by synchronizing cell-cycle exit and differentiation.

This study identifies germ lineage-specific DAF-16 patterning and a role for DAF-16 in early embryogenesis independent of canonical DAF-2 signaling.

This study shows that loss of actinodin1 and actinodin2 genes in fish causes collagen fibers to orient perpendicularly to the epidermis, leading to fin reduction and thickening, and reveals similar patterns in tetrapod limbs.

This study shows that overexpression of TNNI3K in zebrafish impairs heart regeneration by causing chronic inflammation and fibrosis rather than cell-cycle defects.

The paper investigates cultural differences in audiovisual speech perception in infants, finding that Canadian infants show earlier integration of auditory and visual cues than Chinese infants.

This study shows how prepatterned tissue stiffness gradients control organ shape and size through mechanosensing and Wnt5a signaling in sweat glands.

The paper introduces a transgenic zebrafish line that enables precise optogenetic activation of FGF/ERK signaling in vivo.

This study shows that light-dark and dietary cues regulate Drosophila ovarian stem cells by modulating Drp1 on mitochondria to enhance egg production.