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The paper investigates two STAT5B mutations in T cell leukemias, showing one causes gain-of-function and the other loss-of-function, with distinct impacts on immune cell populations and transcriptional activity.

This study establishes TTE reference ranges for mice, showing anesthesia significantly affects cardiac function, with minimal sex differences and modest age-related changes.

The paper shows that hil-1/H1-0, a nutrient-regulated linker histone, mediates resilience and restoration during fasting-refeeding in C. elegans and human cells.

The paper identifies a new wheat powdery mildew resistance gene, PmAT, using BSR-Seq and QTL-Seq analysis on chromosome 2B.

The paper shows that TAF-12 is required for piRNA transcription in C. elegans by recruiting transcription factors and machinery to H3K27me3-enriched regions.

The paper identifies genetic differentiation and develops SNP markers for distinguishing Sebastes species in the northeastern Atlantic, revealing cryptic species and ecotypes.

The paper introduces a method to improve genetic discovery and fine-mapping by analyzing latent factors from high-dimensional traits, showing enhanced power compared to traditional approaches.

This paper evaluates differences in a breast cancer polygenic risk score across genomic platforms and finds that calibration improves consistency in high-risk classification.

The paper analyzes genome-wide data from 432 Peruvian urban individuals to reveal fine-scale population structure, admixture dynamics, and demographic patterns shaped by ancient and recent events.

This paper shows that SEN1 has three distinct roles in yeast meiosis: enabling IME1 gene expression, preventing DNA:RNA hybrid accumulation, and facilitating double strand break repair and chromosome synapsis.

The paper introduces Perturb-tracing, a high-content screening platform to identify regulators of 3D chromatin organization, discovering new factors that influence chromatin folding and nuclear architecture.

This paper introduces a method to classify gene-by-treatment interactions using Bayesian model selection and applies it to molecular count phenotypes with a software package.

The paper demonstrates that allele-specific siRNA can effectively silence a dominant SETX mutation in ALS4, restoring R-loop levels in patient cells.

This study identifies DAF-18/PTEN's role in protecting LIN-35/Rb from cleavage by CLP-1/CAPN to enhance starvation resistance in C. elegans.

The paper conducts a GWAS in European beech to identify genetic markers associated with drought stress traits, finding significant SNPs linked to stomatal density and water use efficiency.

This paper introduces SNP-context and whole-genome feature embeddings using DNABERT-2 for crop phenotype prediction, showing improved accuracy over traditional methods for traits with varying heritability.

The ChickenGTEx project provides a multi-tissue reference of regulatory variants in chicken, analyzing their functional impacts and utility in genetics, genomics, and evolutionary studies.

The paper develops a cytoplasm-aware population to study cytonuclear interactions in barley, identifying cytoplasmic effects on spike traits and improving genomic prediction.

The paper identifies TUP1 as a key gene responsible for ethanol tolerance in yeast strains with chromosome III aneuploidy.

The paper describes an optimized auxin-inducible degron system for conditional protein degradation in Cryptococcus neoformans, enabling the study of essential genes.