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The paper characterizes hepatic lentiviral vector transduction in mice, finding strain-specific variations and QTLs linked to transduction efficiency and kinetics, suggesting the need for personalized gene therapy protocols.

The paper analyzes the transcriptomic differences in 45,X tissues compared to 46,XX and 46,XY controls during early human fetal and placental development, identifying gene expression changes associated with Turner syndrome.

This study improves genomic selection in hexaploid wheat by incorporating additive and epistatic effects, leading to a 3% increase in prediction accuracy for grain yield.

The paper analyzes mutation rates in healthy human tissues using single-cell data to identify genetic and epigenetic factors influencing mutability across different tissues.

This study shows that fmo-4 in C. elegans extends lifespan and stress resistance by regulating calcium homeostasis through interactions with known longevity pathways.

This paper describes a novel RNA splicing system, SOS splicing, that removes transposons from mRNAs in C. elegans and human cells, protecting genes from TE-mediated disruption.

The paper performs a multi-breed meta-GWAS in pigs to identify genomic regions associated with complex traits and integrates with PigGTEx to prioritize variant-gene-tissue-trait circuits.

This study uses random regression models to analyze longitudinal dry matter yield data from perennial forage species, identifying genotype adaptability and stability through reaction norms.

The paper investigates how recombination machinery affects mutation rates in plant organellar genomes using mutant lines and sequencing techniques.

The paper identifies structural variants in maize using whole genome alignment and short-read sequencing, linking them to life history traits and genotype-by-environment interactions.

This paper introduces a method to increase the proportion of correctly repaired hepatocytes in the liver through transient gene inhibition and transgene delivery, achieving a 25% increase in targeted cells and five-fold transgene expression.

The paper introduces a statistical method using trigonometry to detect nonlinear genetic relationships between traits, finding nonlinear associations between BMI and psychiatric traits but not between height and psychiatric traits.

The paper investigates how maternal thyroid hormone exposure affects DNA methylation at a leptin upstream enhancer in adipose tissue, with sex-specific impacts on body fat percentage.

The paper compares statistical learning methods for predicting complex traits from gene expression in Drosophila, finding method-specific accuracy differences and improved performance with functional annotations.

This study shows that inhibiting cathepsin B reduces amyloid deposits in mouse models of lysosomal diseases, suggesting it as a potential therapeutic target.

This paper proves the central limit theorem for the number of mutations in a sample from a large population, showing it approximates a normal distribution under certain evolutionary models.

The paper identifies a serine codon hierarchy that affects translation efficiency in Bacillus subtilis, showing that TCN codons cause ribosome pausing and regulate gene expression, including the sda gene involved in sporulation and biofilm formation.

The paper reports a novel TRPC6 mutation causing autosomal dominant FSGS and shows that combined Sildenafil and Losartan therapy improves podocyte dysfunction.

This work benchmarks DNA sequence models for predicting causal regulatory variants in human genetics using a curated dataset of 113 Mendelian and 83 complex traits.

The paper identifies adaptation strategies in aneuploid cancer cells through in vitro evolution and multi-omics analysis, revealing key transcription factors and genomic changes that improve proliferation and survival.