Discover, rate, and discuss biology preprints.

The paper shows that random search by CD8 T cells for Plasmodium parasites is efficient in liver sinusoids, challenging the need for attraction-based search.

This study identifies CXCL5 as a factor that increases alveolar-epithelial barrier permeability in acute lung injury, independent of neutrophil recruitment.

This study examines age-related changes in alveolar macrophages of rhesus macaques, finding increased inflammation and identifying MIF as a potential biomarker for age-associated lung disease.

The paper introduces Met-Vision, an imaging-based pipeline that identifies four distinct metabolic states in tissue macrophages, showing metabolic diversity during inflammation.

This study uses single-nucleus RNA sequencing to identify two distinct endothelial response patterns to ISAV infection in Atlantic salmon.

This study characterizes the gene regulatory network of early human B-cell development and identifies regulatory elements linked to B-cell acute lymphoblastic leukemia.

This study identifies Bhlhe40 as a key regulator of T cell effector differentiation, showing distinct roles in CD4 and CD8 T cells for anti-PD-1 and anti-CTLA-4 therapies.

This study shows that inhibiting monocyte migration via CCR2 deficiency reduces arterial thrombosis and improves thrombolysis in mice.

This study identifies bacterial exposure as a key driver of immune ageing and shows residual bacterial DNA in immune cells predicts immune age changes.

This study identifies RBPJ-mediated epigenetic regulation of efferocytosis in macrophages, showing that suppression of H3K9me3 enhances apoptotic cell clearance and suppresses inflammation.

Booster SARS-CoV-2 mRNA vaccine recruits and broadens GC B cell responses targeting a highly conserved site on receptor binding domain of spike glycoprotein.

This study shows that macrophage fatty acid synthesis promotes fibroblast expansion and fibrosis after myocardial infarction.

This study optimizes the dose and timing of MSC-derived culture-conditioned media (CCM) to enhance its immunomodulatory effects on CD3+ T-cells in acute graft-versus-host disease.

This study examines how BCG vaccination at birth affects MR1T cell TCR usage and function in infants, finding increased type I interferon response and a TCR cluster enriched in vaccinated infants.

This study shows that disrupting autophagy in CAR-T cells enhances their metabolic activity and improves their ability to reject ovarian tumors in vivo.

This study creates the first multiomic single-cell spatial atlas of palatine tonsils in infectious mononucleosis, revealing EBV's epithelial tropism and immunosuppressive microenvironment.

This study compares human and murine macrophage responses to Mtb infection, identifying shared and distinct immune pathways and cytokine expression patterns between alveolar and monocyte-derived macrophages.

This study investigates how heme oxygenase-1 (HO1) affects interferon-stimulated gene (ISG) expression in response to various stressors, finding that TNF is a key inducer and HO1 influences nuclear retention of inflammatory transcription factors.

This study shows that older females have more inflammatory monocytes, which is reversed by Hormone Replacement Therapy.