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The paper profiles the metabolome and genomes of five amaranth cultivars to assess nutritional quality and genetic differences.

The paper presents a gapless Landrace pig genome assembly that improves resolution of repetitive regions and reveals breed-specific telomere repeat structures.

This paper develops an engineered Bacillus subtilis spore system for sustained gastrointestinal delivery of pentameric GLP-1, showing glucose-lowering and weight-reduction effects in mice.

The paper shows that light cues prepare the genome for rapid metamorphosis in marine sponges by priming chromatin structure before environmental induction.

This study investigates whether nucleotide supplementation improves growth recovery in starved charrs by examining one-carbon metabolism changes during refeeding.

The paper uses iPSC-derived liver cells to show SAHA reduces Z-alpha-1-antitrypsin polymers by increasing chaperone expression in AATD models.

This paper introduces Fiber-seq, a method for detecting chromatin accessibility on individual DNA fibers, and provides guidelines for its proper use and analysis.

The paper uses molecular dynamics simulations to study how D-Retro-Inverso peptides modulate TTR fibril stability and identifies DRI-K6V as a potential disruptor of TTR fibrils.

The paper presents an end-to-end pipeline for segmenting nanoparticles and cellular structures in 3D electron microscopy data of tumor spheroids, revealing preferential NP clustering near nuclei.

This paper introduces TRAEV, a computational framework to predict the evolutionary robustness of metabolic traits in microbial cells, validated using yeast strains in controlled environments.

The paper reports the first record of the Eucerotinae subfamily in mainland Afrotropics and describes a new species from Uganda and Cameroon.

This paper develops Gem-miR-15a, a gemcitabine-modified microRNA, which overcomes 5-FU and oxaliplatin resistance in colorectal cancer with high potency and low toxicity.

This paper tests the neuroprotective effects of MNP-021 against diabetes-induced glucotoxicity and neuroinflammation in neurons and glial cells, finding it restores glucose handling, mitochondrial function, and pro-resolving signaling.

The paper introduces a framework for simulating multicompartment neurons with customizable subcellular dynamics using NEST and NESTML, enabling efficient and scalable network simulations.

This study uses patient-specific Fluid-Structure Interaction simulations to predict post-TEVAR endoleaks by quantifying hemodynamic drag forces and proposing a risk factor R.

This study shows sulforaphane extends C. elegans lifespan by over 50% when administered early and reduces transcriptional age by 20%.

The paper evaluates precomputed SpliceAI scores for splice-altering variant prioritization in NDD cohorts, finding inaccuracies and providing a tool to improve variant triage.

The paper reanalyzes a cryo-EM dataset using advanced methods to uncover a minor reactivation-state structure of methionine synthase, revealing conformational changes during cofactor turnover.

The paper identifies shared genetic variants between hypertension and preeclampsia that regulate immune-related genes, linking gene expression to blood pressure traits and clinical phenotypes.

This study quantifies how environmental factors and frequency affect signal detection in Passive Acoustic Monitoring using playback experiments in a tropical agroecosystem.