Discover, rate, and discuss biology preprints.

LineageFlow predicts clonal fate and transcriptional profiles by integrating growth dynamics and state transitions in single-cell lineage data.

This study uses human precision cut kidney slices to analyze gene expression responses to culture conditions and IFNγ stimulation, showing reproducible APOL1 expression changes.

mixKIN improves kinship estimation from low-coverage genomes by accounting for ancestry, outperforming existing methods in admixed and heterogeneous populations.

This study shows macrophage-derived ROS restricts A. fumigatus germination and hyphal growth, while fungal melanin limits ROS activity, promoting immune evasion.

This paper introduces a method to estimate protein-induced curvature of lipid bilayers using molecular simulations by correlating molecular position with curvature in thermally fluctuating bilayer modes.

ClonoDeconv estimates paired TCR clonotype proportions from bulk-TCR sequencing using a single-cell reference, capturing longitudinal T-cell clonal dynamics.

The paper identifies 22,377 de novo genes in 21 Brassicaceae genomes, showing variation in birth/death rates and factors influencing their turnover.

This paper introduces a mathematical model to correct for reaction-time-induced overshoot in continuous flash suppression paradigms, revealing asymmetry in thresholds for entering and exiting awareness.

This study shows LGP2 is not just a recruitment factor for MDA5 but becomes an integral part of MDA5 filaments, stabilizing them and reducing the number of MDA5 molecules needed for signaling.

This study investigates how mechanical pulling affects the unbinding of a cellulosomal carbohydrate-binding module from cellulose using simulations and experiments, showing that pulling orientation significantly impacts unfolding and unbinding dynamics.

RDEmbed uses sentence embeddings to analyze rare disease phenotypes from clinical text, outperforming ontology-based methods in similarity analysis and clustering.

The paper uses spatial proteomic profiling to analyze cardiac stromal populations and microenvironments in systemic sclerosis-associated myocarditis, identifying distinct fibroblast subtypes and their spatial interactions.

This study compares the neurophysiological and molecular recovery from isoflurane anesthesia with sleep and sleep deprivation in mice, finding distinct gene expression patterns and EEG features.

The paper investigates how regulatory and catalytic domains of ADP-ribosyltransferases co-evolve, showing functional complementarity across species and enzyme classes.

This study identifies LIN28B as a post-transcriptional regulator of Wnt/{beta}-catenin signalling in myeloid leukemia cells and shows that dual targeting enhances cytotoxicity.

This study identifies GPNMB as a critical regulator of lysosomal function in macrophages, essential for myelin clearance and nerve regeneration after peripheral nerve injury.

This study identifies DNAJC13 as a critical regulator of TLR7 trafficking and shows its role in preventing autoimmunity in mice and humans.

The paper develops a new whole slide image analysis method to detect and quantify hepatocellular vacuolization in European flounder exposed to multiple pollutants, showing significant differences between polluted and control sites.

The paper generates a chromosome-level reference genome for Crassostrea virginica using PacBio HiFi, Illumina, and Hi-C data, achieving high completeness and reduced duplication.

The paper evaluates six alveolar macrophage models to identify those best representing in vivo AMs for assessing nanomaterial toxicity, finding AMs GTR and BM-AMs most suitable.