A. Goldman

Controlled tumor heterogeneity in a co-culture system by 3D bio-printed tumor-on-chip model

This paper develops a 3D bioprinted tumor-on-chip model to study tumor heterogeneity and cell migration in breast cancer.

Spatial and temporal metagenomics of river compartments reveals viral community dynamics in an urban impacted stream

The paper analyzes spatial and temporal metagenomic data from a wastewater-impacted river to reveal viral and microbial community dynamics and their potential roles in biogeochemical cycles.

Immune Contexture of Isocitrate Dehydrogenase stratified Human Gliomas

The paper provides a comprehensive analysis of immune contexture in IDH stratified human gliomas using single-cell RNA sequencing and spectral cytometry, identifying TREM2 as a novel immunotherapy target.

Functional and structural asymmetry suggest a unifying principle for catalysis in integral membrane-bound pyrophosphatases

This study presents the first structure of a K+-independent M-PPase and shows asymmetric and time-dependent substrate binding, proposing a unified model for ion pumping and energy coupling in M-PPases.

MTCH2 cooperates with MFN2 and lysophosphatidic acid synthesis to sustain mitochondrial fusion

This study identifies cooperative mechanisms between MTCH2, MFN2, and lysophosphatidic acid synthesis in sustaining mitochondrial fusion.

mPPases create a conserved anionic membrane fingerprint as identified via multi-scale simulations

The paper uses multiscale simulations to show mPPases form conserved anionic lipid interactions at specific sites across different species.

Phospholipid Metabolism Is Associated with HIV Rebound Upon Treatment Interruption

This study links phospholipid and lysophospholipid levels to faster HIV rebound after treatment interruption, suggesting their role in viral persistence and inflammation.

Carbon limitation leads to thermodynamic regulation of aerobic metabolism

The paper tests OM thermodynamics as a regulator of aerobic respiration, showing it dominates under carbon limitation and shifts to nitrogen content when carbon is in excess.

Vimentin protects the structural integrity of the nucleus and suppresses nuclear damage caused by large deformations

This study shows that vimentin intermediate filaments protect the nucleus from damage during cell migration by maintaining its shape and mechanical integrity.