Author

M. Howarth

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Bioengineering· 2 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:drug response / drug discovery· 5 Assay:proteomics· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

P. J. Bjorkman· 3 shared A. A. Cohen· 2 shared A. H. Keeble· 2 shared A. P. West· 2 shared J. Gilbert-Jaramillo· 2 shared J. R. Keeffe· 2 shared L. M. Kakutani· 2 shared M. C. Nussenzweig· 2 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersImmunology

P. J. Bjorkman

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Author profile →

8 papers

Recent·Most cited

Preclinical Development of a Stabilized RH5 Virus-Like Particle Vaccine that Induces Improved Anti-Malarial Antibodies

L. D. W. King, D. Pulido, J. R. Barrett, H. Davies, D. Quinkert, A. M. Lias, S. E. Silk, D. J. Pattinson, A. Diouf, B. G. Williams, K. McHugh, A. Rodrigues, C. A. Rigby, V. Strazza, J. Suurbaar, , S. J. Draper

This paper develops a stabilized RH5 VLP vaccine that induces improved anti-malarial antibodies compared to a soluble protein vaccine in preclinical studies.

bioRxiv · Jan 4, 2024Immunology

iMAX FRET (Information Maximized FRET) for multipoint single-molecule structural analysis

B. S. Joshi, C. V. de Lannoy, M. Howarth, S. H. Kim, C. Joo

The paper introduces iMAX FRET, a single-molecule method for structural analysis that captures 3D biomolecular structures and conformational changes through FRET and geometrical reconstruction.

bioRxiv · Sep 27, 2023 · PreprintBiophysics

SpyMask Enables Combinatorial Assembly of Bispecific Binders

C. L. Driscoll, A. H. Keeble, M. Howarth

SpyMask enables efficient, modular assembly of bispecific binders using SpyTag/SpyCatcher chemistry, revealing activity dependent on binder order and scaffold geometry.

bioRxiv · Aug 31, 2023Bioengineering

Multiviral Quartet Nanocages Elicit Broad Anti-Coronavirus Responses for Proactive Vaccinology

R. A. Hills, T. K. Tan, A. A. Cohen, J. R. Keefe, A. H. Keeble, P. N. Gnanapragasam, K. N. Storm, M. L. Hill, S. Liu, J. Gilbert-Jaramillo, M. Afzal, A. Napier, W. S. James, P. J. Bjorkman, A. R. Townsend, M. Howarth

A vaccine candidate with polyprotein antigens displayed on nanocages induces neutralizing antibodies to multiple SARS-like coronaviruses.

bioRxiv · Feb 24, 2023 · PreprintImmunology

CD4-binding site immunogens elicit heterologous anti-HIV-1 neutralizing antibodies in transgenic and wildtype animals

H. B. Gristick, H. Hartweger, M. Loewe, J. van Schooten, V. Ramos, T. Y. Oliviera, Y. Nishimura, N. S. Koranda, A. Wall, K.-H. Yao, D. Poston, A. Gazumyan, M. Wiatr, M. Horning, J. R. Keeffe, , P. J. Bjorkman

This study shows that CD4bs immunogens can elicit potent, broad anti-HIV-1 neutralizing antibodies in transgenic and wildtype animals.

bioRxiv · Sep 8, 2022Immunology

Modular capsid decoration boosts adenovirus vaccine-induced humoral and cellular immunity against SARS-CoV-2

M. D. J. Dicks, L. M. Rose, L. A. H. Bowman, C. Graham, K. J. Doores, M. H. Malim, S. J. Draper, M. Howarth, S. Biswas

This paper describes a method to enhance adenovirus vaccine efficacy by decorating capsid surfaces with antigens, resulting in improved humoral immunity and retained T cell responses.

bioRxiv · Feb 20, 2022Bioengineering

Mosaic nanoparticles elicit cross-reactive immune responses to zoonotic coronaviruses in mice

A. A. Cohen, P. N. P. Gnanapragasam, Y. E. Lee, S. Ou, L. M. Kakutani, J. R. Keeffe, C. O. Barnes, H.-J. Wu, M. Howarth, A. P. West, M. C. Nussenzweig, P. J. Bjorkman

The paper demonstrates that mosaic nanoparticles displaying multiple coronavirus RBDs induce cross-reactive and neutralizing antibodies against SARS-CoV-2 and zoonotic coronaviruses in mice.

bioRxiv · Nov 17, 2020Immunology

Plasmablast-derived antibody response to acute SARS-CoV-2 infection in humans

K.-Y. A. Huang, T. Tan, T.-H. Chen, C.-G. Huang, R. Harvey, S. Hussain, C.-P. Chen, A. Harding, J. Gilbert-Jaramillo, X. Liu, M. Knight, L. Schimanski, S.-R. Shih, Y.-C. Lin, C.-Y. Cheng, , A. Townsend

This study analyzes plasmablast-derived antibodies in three COVID-19 patients, identifying neutralizing antibodies and cross-reactivity with other betacoronaviruses.

bioRxiv · Aug 28, 2020 · PreprintMicrobiology