A. Zhang

The paper investigates microbiota dynamics and assembly patterns in a large water diversion canal, finding deterministic processes shape bacterial communities while stochasticity dominates micro-eukaryotic communities.

This study evaluates a multivalent Ad-vectored vaccine delivered via respiratory mucosal route, showing robust protection against SARS-CoV-2 and variants in mice.

This study shows that hyperglycemia represses HIF-1, leading to increased mitochondrial ROS production and renal injury in diabetes, which can be mitigated by restoring HIF-1 function.

This study identifies the DEPDC1-EEF1A1-FOXO3a axis as a critical pathway promoting osteosarcoma progression by downregulating FOXO3a, with implications for therapeutic strategies.

This study examines the effects of imidacloprid and thiamethoxam at LC30 and LC50 concentrations on the life table parameters of soybean aphid, showing significant changes in reproduction and development rates.

The paper shows that negative DNA supercoiling reduces stochasticity in protein-mediated DNA looping, making it deterministic and ergodic within bacterial doubling time.

This study identifies MYC as a key driver of metastatic heterogeneity in pancreatic cancer by linking its activity to increased metastasis through TAM recruitment.

This paper introduces a precision-targeted metabolomics method capable of analyzing diverse biological matrices and identifies differential metabolomes in rats with CCl4-induced hepatitis.

The paper reports a proteomics resource analyzing protein expression in mouse adult and aged hematopoietic stem cells and their progenitors, revealing differential expression and gene regulation.

The paper identifies OsMKK1 as a direct target of OsDMI3 and shows that OsDMI3-mediated phosphorylation of OsMKK1 is crucial for ABA signaling and stress responses.

This study shows that changes in plasma cfDNA levels during chemotherapy predict clinical response in NSCLC patients, with specific insights for lung adenocarcinoma.

This study compares the gut DNA and RNA viromes of Chinese residents and Pakistani visitors, finding ethnic origin significantly influences virome composition and diversity.

The paper analyzes RNA editing in plant chloroplasts using RNA-seq data from three lineages, identifying 5,389 editing sites and revealing evolutionary patterns and functional impacts.

This paper develops a molecular clamping assay called ColoScape for early colorectal cancer detection using XNA-mediated qPCR, showing high sensitivity and specificity in clinical samples.

The paper shows Gβγ interacts with RNA polymerase II in cardiac fibroblasts, negatively regulating fibrotic gene expression, with cell-specific signaling pathways involved.

This study identifies strawberry-derived pelargonidin as a safe and effective permeability enhancer for oral delivery of protein drugs in mice.

This study identifies strain-level features of the mouse gut microbiota using metagenome-assembled genomes, revealing distinct genomic and functional characteristics compared to human gut microbes.

This paper reveals the atomistic mechanism of NompC channel opening under intracellular compression using simulations and experiments, showing force transmission through ankyrin repeats and linker helices to the TRP domain.

This study shows that rabies virus glycoprotein suppresses gastric cancer migration by inhibiting the 7-nAChR-MEK/ERK-EMT pathway.

This study identifies lncRNA-PCG pairs regulated by PBDE exposure and their involvement in intermediary metabolism pathways.

This study shows that modulating S1PR1 and S1PR2 improves chemotherapy delivery and efficacy in Ewing sarcoma by normalizing tumor vessel permeability.

This study investigates how temperature affects RNA editing in grape organelles, finding that editing levels decrease with rising temperature and that PPR gene expression declines, potentially contributing to stress adaptation.

This study identifies ALI-1 as a candidate gene for the B1 locus, showing its role in regulating awn length and grain weight in wheat through cytokinin suppression.

This paper identifies Neogenin-1 as a marker distinguishing myeloid-biased from balanced Hoxb5+ long-term hematopoietic stem cells in mice, revealing their functional heterogeneity and hierarchical relationship.

This study reveals the Ca2+ permeation mechanism through RyR1 using molecular dynamics simulations, showing a one-at-a-time hydrated ion translocation pattern.

This study evaluates bio-bitumen made from biomass pyrolysis oil as a substitute for petro-bitumen in coating sheets, showing improved adhesion, temperature stability, mechanical strength, and flexibility.

This paper uses SERS to determine molecular orientation in lipid membranes, finding specific polar and roll angles for di-4-ANEPPS.

This study reconstitutes Dmc1-mediated meiotic recombination in vitro and identifies RPA's role in enhancing Dmc1 activity by overcoming ssDNA structure inhibition and stabilizing D-loops.

This study shows that KMO inhibition protects against renal ischemia-reperfusion injury in mice by reducing renal damage and inflammation.