C. Dupont

SON-dependent nuclear speckle rejuvenation alleviates proteinopathies

This study identifies pyrvinium pamoate as a compound that rejuvenates nuclear speckles, improving protein quality control and reducing YAP1 activity, thereby alleviating proteinopathies in pre-clinical models.

The multifunction Coxiella effector Vice stimulates macropinocytosis and interferes with the ESCRT machinery

This study identifies the Coxiella effector Vice as a protein that manipulates host cell lipid composition and cellular pathways to form the Coxiella-containing vacuole.

Host-Microbiome Associations in Saliva Predict COVID-19 Severity

The paper examines the relationship between salivary microbiome and host parameters in COVID-19 patients, finding that microbiome diversity and salivary cytokines predict disease severity.

Variation in colour signals among Sarracenia pitcher plants and the potential role of areoles in the attraction of flying Hymenoptera

The paper examines color variation in Sarracenia pitcher plants and its role in attracting flying Hymenoptera, finding that contrasting areoles may act as visual lures.

Roscovitine exacerbates Mycobacterium abscessus infection by reducing NADPH oxidase-dependent neutrophil trafficking

This study shows Roscovitine reduces neutrophil trafficking by inhibiting NADPH oxidase, worsening Mycobacterium abscessus infection in CF models.

Microbiota and stress: a loop that impacts memory

This study shows that chronic stress alters gut microbiota in quails, and transferring this microbiota to germ-free hosts impairs memory and increases anxiety-like behavior.

The mechanism underlying transient weakness in myotonia congenita

This study identifies plateau potentials caused by Na+ and Ca2+ currents in Becker disease models and shows that inhibiting NaPIC with ranolazine prevents transient weakness.

The influence of substrate concentration on the culturability of heterotrophic soil microbes isolated by high-throughput dilution-to-extinction cultivation

This study isolates subsurface soil microbes using high-throughput dilution-to-extinction culturing and shows that substrate concentration affects culturability of specific microbial lineages.

Microbiome disturbance and resilience dynamics of the upper respiratory tract in response to influenza A virus infection in analog hosts

The paper examines how influenza A virus infection affects the upper respiratory tract microbiome in humans and ferrets, finding that infected individuals experience microbiome disturbances that recover over time.

Supragingival plaque microbiome ecology and functional potential in the context of health and disease

This study examines the supragingival plaque microbiome in children to link microbial diversity and function to caries, identifying key metabolic pathways and novel microbes associated with disease.

Patterns of thaumarchaeal gene expression in culture and diverse marine environments

The paper investigates thaumarchaeal gene expression under ammonia limitation and across environments, identifying core genes involved in ammonia oxidation.

Allele-specific control of replication timing and genome organization during development

This study identifies allele-specific replication timing and genome organization differences in hybrid mouse embryos and shows they diminish during differentiation.