C. Zhou

This study identifies Kindlin-2 as a protective factor in articular cartilage, showing its role in preventing osteoarthritis through regulation of Stat3 and Runx2 pathways.

The paper identifies a new native gluten epitope recognized by cross-reactive B cells in celiac disease, which may contribute to epitope spreading.

This study identifies the LCK-14-3-3ζ-TRPM8 axis as a regulator of TRPM8 function and assembly, promoting pancreatic cancer malignancy through phosphorylation at Y1022.

This study uses optical coherence tomography to track the morphological and functional development of human heart organoids over time.

This study tracks SARS-CoV-2-specific T cell cytokine responses over one year, finding persistent multi-cytokine production with greater immunity linked to disease severity.

This study identifies novel viral genomic components and evolutionary patterns using conserved untranslated regions (UTRs) and UTR-backed iterative BLASTn in multipartite viruses.

This study shows that CSF1R inhibition affects T-helper cell differentiation in CD4+ cells, independent of microglia depletion.

The paper uses long-read RNA sequencing to study polyadenylation and transcript usage changes in host cells during SARS-CoV-2 infection, identifying differential polyadenylation and transcript usage in infected cells.

This study shows that TAM proliferation in PDAC is driven by CSF1 from fibroblasts, leading to immunosuppression and tumor progression, but also increasing sensitivity to CD40 agonist therapy.

This study shows that OsLEC1 inhibits photosynthesis in rice embryos to promote seed dormancy by regulating hormonal pathways and gene networks.

The paper examines genetic and clonal diversity in Leymus chinensis patches, finding strong genetic structure and clonal reproduction within patches.

This study investigates cell-type apoptosis in lung tissues during SARS-CoV-2 infection, finding both intrinsic and extrinsic apoptotic pathways are activated, while some cell types remain refractory to infection.

This study investigates how EPAC1 regulates rickettsial adhesion to endothelial cells by modulating ANXA2 Y23 phosphorylation, using in vivo models and FluidFM.

This study identifies the DEPDC1-EEF1A1-FOXO3a axis as a critical pathway promoting osteosarcoma progression by downregulating FOXO3a, with implications for therapeutic strategies.

This paper develops a non-viral method for efficient T cell genome editing using modified plasmids, achieving CAR-T cell functionality comparable to AAV-based methods.

This study examines SARS-CoV-2 transcriptional and epi-transcriptional dynamics using long-read sequencing in human and primate infection models, revealing distinct patterns of sgRNA regulation and modification.

This study investigates the role of Rickettsia-infected endothelial cell-derived exosomes in causing barrier dysfunction in brain microvascular endothelial cells, identifying miR-23a and miR-30b as key regulators.

A mouse-adapted SARS-CoV-2 strain with RBD mutations caused 100% mortality in aged male BALB/c mice and showed altered receptor binding affinity.

This paper introduces a fast 3D printing method called FLOAT to create large-scale biocompatible hydrogel models with minimal deformation and cellular injury.

DyRAST uses dynamic laser speckle imaging and machine learning to rapidly predict antibiotic minimum inhibitory concentrations in E. coli within 60 minutes.

This study shows oxidative stress reduces Nampt mRNA and protein levels in PC12 cells, contributing to cell death and NAD+ deficiency.

This paper develops a scalable, high-fidelity in vitro model of human cardiac development using hPSCs, showing high similarity to fetal hearts in morphology and cell-type complexity.

The paper uses TMT-based proteomics to compare host protein responses to virulent and low virulent Listeria monocytogenes strains in intestinal organoids, identifying differentially expressed proteins and their functional roles.

The paper identifies lipid droplet-like structures in gut microbiota from mouse and human samples and establishes a method to study them.

This study identifies Rab18's role in lipid droplet dynamics by showing it binds PLIN2 and ACSL3, promoting TAG accumulation and LD growth in muscle cells.

The paper analyzes single-cell RNA-seq data from plasma cells in celiac disease patients to identify transcriptional differences and clonal relationships between disease-specific and non-specific plasma cells.

This study identifies METTL5 as an 18S rRNA-specific m6A methyltransferase that modulates stress response gene expression by affecting translation.

The paper studies the binding and enzymatic activity of LD proteins using adiposomes, showing PI's effect on PLIN2 and ATGL.

This paper reports the cryo-EM structure of the C9ORF72-SMCR8-WDR41 complex, revealing its role as a GAP for Rab8a and Rab11a.

This study shows that a loss-of-function mutation in IL-17F increases susceptibility to oropharyngeal candidiasis in mice, but not in heterozygous carriers.