Author

Daniel Ortmann

Wellcome/MRC Cambridge Stem Cell Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Developmental Biology· 5

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Research Focus:differential expression· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:clustering· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Ludovic VallieriD· 4 shared Brandon Tyler WesleyiD· 2 shared Carola Maria MorelliD· 2 shared Ekaterini D. ZacharisiD· 2 shared José Garcia‐BernardoiD· 2 shared Kourosh Saeb‐ParsyiD· 2 shared Rodrigo A. GrandyiD· 2 shared Rute A. TomaziD· 2 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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4 shared papersDevelopmental Biology

Ludovic VallierORCID

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5 papers

Recent·Most cited

Single-cell atlas of human liver development reveals pathways directing hepatic cell fates

Brandon Tyler Wesley, Alexander Ross, Daniele Muraro, Zhichao Miao, Sarah H. Saxton, Rute A. Tomaz, Carola Maria Morell, Katherine Ridley, Ekaterini D. Zacharis, Sandra Petrus-Reurer, Judith Kraiczy, Krishnaa T. A. Mahbubani, Stephanie Emma Brown, José Garcia‐Bernardo, Clara Alsinet, , Ludovic Vallier

This study creates a single-cell atlas of human liver development, identifying pathways and factors that guide hepatic cell fates and improving hepatocyte-like cell functionality.

Nature Cell Biology · Sep 15, 2022Peer-reviewedDevelopmental Biology

Generation of functional hepatocytes by forward programming with nuclear receptors

Rute A. Tomaz, Ekaterini D. Zacharis, Fabian Bachinger, Annabelle Wurmser, Daniel Yamamoto, Sandra Petrus-Reurer, Carola Maria Morell, Dominika Dziedzicka, Brandon Tyler Wesley, Imbisaat Geti, Charis‐Patricia Segeritz, Miguel Cardoso de Brito, Mariya Chhatriwala, Daniel Ortmann, Kourosh Saeb‐Parsy, Ludovic Vallier

This study generates functional hepatocytes from human pluripotent stem cells using forward programming with nuclear receptors, bypassing the limitations of traditional differentiation methods.

eLife · Jul 26, 2022Peer-reviewedDevelopmental Biology

Analysis of Endothelial-to-Haematopoietic Transition at the Single Cell Level identifies Cell Cycle Regulation as a Driver of Differentiation

Giovanni Canu, Emmanouil I. Athanasiadis, Rodrigo A. Grandy, José Garcia‐Bernardo, Paulina M. Strzelecka, Ludovic Vallier, Daniel Ortmann, Ana Cvejic

This study identifies cell cycle regulation as a driver of endothelial-to-haematopoietic transition using single-cell transcriptomics in a human pluripotent stem cell system.

Genome biology · Jul 1, 2020Peer-reviewedDevelopmental Biology

Cell cycle regulators control mesoderm specification in human pluripotent stem cells

Loukia Yiangou, Rodrigo A. Grandy, Anna Osnato, Daniel Ortmann, Sanjay Sinha, Ludovic Vallier

This study investigates how cell cycle regulators influence mesoderm specification in human pluripotent stem cells, finding that CDKs and pRb phosphorylation are context-dependent for efficient mesoderm formation.

Journal of Biological Chemistry · Sep 12, 2019Peer-reviewedDevelopmental Biology

Human axial progenitors generate trunk neural crest cells

Thomas J.R. Frith, Ilaria Granata, Matthew Wind, Erin Stout, Oliver Thompson, Katrin Neumann, Dylan Stavish, Paul Roy Heath, Daniel Ortmann, James O.S. Hackland, Konstantinos Anastassiadis, Mina Gouti, James Briscoe, Valerie A. Wilson, Stuart L. Johnson, , Anestis Tsakiridis

This study identifies that human axial progenitors generate trunk neural crest cells and defines their molecular signatures.

eLife · Aug 10, 2018Peer-reviewedDevelopmental Biology