H. Li

The paper identifies an evolutionary conserved NO-producing system in fungi, mammals, and plants, revealing multifunctional enzymes with implications for agriculture and medicine.

The paper identifies Fab-dimerized glycan-reactive antibodies in HIV-infected macaques and HIV-naïve humans that neutralize HIV-1 and can be elicited by vaccination.

This paper improves an adenine base editor for in vivo use, achieving efficient dystrophin restoration in dystrophic mice with minimal off-target effects.

This paper uses Nanoparticle Tracking Analysis (NTA) to characterize magnetosome size distribution and concentration changes under ultrasonication and SDS treatment.

The paper evaluates a new qPCR curve analysis method, CqMAN, against existing approaches using clinical and dilution datasets, showing it is comparable and suitable for qPCR data processing.

This study shows that combining controlled-release urea with 300 kg ha-1 potassium chloride improves soil fertility, plant growth, and yield of Italian ryegrass.

The paper screens SARS-CoV-2 target cells across 11 animal species using single-cell transcriptomes, finding higher proportions in cats and detecting them in multiple pig cell types.

This paper identifies and profiles bisecting N-acetylglucosamine modifications in human amniotic membrane through glycomic and glycoproteomic analyses, revealing 41 glycoproteins with this modification.

This study identifies SETD2 as a factor that interacts with hnRNP L to regulate alternative splicing by linking transcription and splicing through its SHI domain.

The paper uses scRNA-seq to compare ACE2 expression and bladder cell clusters in OAB and healthy mice, finding reduced umbrella cells and higher ACE2 in epithelial cells, suggesting altered 2019-nCoV infection pathways.

This study shows that the disordered N-terminal region of SETD2 regulates its proteasome-mediated decay, affecting H3K36me3 deposition and transcriptional fidelity.

This study reports the largest sequenced plant genome, Paris polyphylla var. yunnanensis, and identifies genes involved in polyphyllin biosynthesis.

This study investigates the evolution, cross-species transmission, and origin of bat coronaviruses in China using sequence data and Bayesian analysis.

This paper introduces two growth-based selections in E. coli to engineer CHMO with improved thermostability and NADH cofactor specificity.

The paper discovers a high-magnesium calcite armor in leaf-cutter ants, showing it enhances exoskeleton hardness and protects against predation and fungal infection.

This paper describes a growth-based selection platform for evolving 4-hydroxybenzoate hydroxylase to accept 3,4-dihydroxybenzoic acid, achieving higher catalytic efficiency.

This paper shows that using a nicotinamide mononucleotide redox cofactor system in E. coli enables efficient aldehyde accumulation by targeting specific enzymes and reducing byproducts.

This study shows that a 3D fibronectin nano-array on a fibrin matrix accelerates mouse skin wound healing by enhancing cell adhesion, proliferation, and vascular morphogenesis.

This study investigates tree shrew susceptibility to SARS-CoV-2 infection and finds that they show mild symptoms and low viral replication, suggesting limited susceptibility.

PlanktonScope provides an affordable modular imaging platform for oceanographic research, enabling high-throughput imaging in both lab and field settings.

This study evaluates the cytotoxicity of chloroquine and hydroxychloroquine in multiple cell lines and tissues using a dynamic imaging system and PBPK model, finding HCQ less toxic than CQ in most cases.

The paper shows that egg-surface bacteria in Bactrocera dorsalis increase β-caryophyllene in fruits, deterring oviposition by conspecific flies.

The paper identifies and characterizes two new families of anion channelrhodopsins (ACRs), including RubyACRs with highly red-shifted absorption spectra, expanding optogenetic tools for neural inhibition.

This study identifies three groups of direct repeats in Anabaena sp. PCC 7120 by analyzing the specificities of two Cas6 endonucleases, showing cross-recognition and functional coordination in CRISPR-Cas systems.

The paper shows that ribosome stalling and phase separation are critical for transposon RNA processing and epigenetic silencing in plants.

This study compares SARS-CoV-2 infection outcomes in three non-human primate species, finding that M. mulatta is most susceptible, followed by M. fascicularis and C. jacchus.

This study shows that miR-203 suppresses pancreatic cancer cell proliferation, invasion, and migration by down-regulating FGF2 expression.

This paper combines CIS checkpoint deletion with CAR engineering in NK cells to enhance their metabolic fitness and anti-tumor activity in a lymphoma model.

The paper identifies 19 new BCCR proteins from cryptophyte algae, revealing distinct conductance mechanisms and rapid desensitization in two subfamilies through electrophysiology and spectroscopy.

This paper describes the development of DN052, a novel TLR8 agonist with high potency and selectivity, showing strong antitumor activity and favorable safety profile, leading to phase I clinical trials.