H. Li

This study identifies immune mechanisms underlying CyHV-3 resistance in a common carp strain through transcriptomic analysis of gene and lncRNA expression.

This paper introduces a method to assess cell viability without staining using phase imaging and deep learning, achieving 95% accuracy in distinguishing live and dead cells.

Vectorchip enables high-throughput analysis of individual mosquito bites to study pathogen transmission dynamics and infectious viral particles.

This study identifies bacterial swarmers as protective against intestinal inflammation in mice and humans, showing their ability to enrich beneficial gut microbes.

The paper introduces a photoswitchable tag technology to isolate and analyze live cells from specific regions in complex tissues, enabling spatially defined single-cell RNA sequencing.

This study identifies 129 loci associated with 27 yield-related traits in tomato, explaining 8.8% of phenotypic variance, and highlights a candidate gene involved in leaf stomata formation and drought resistance.

This study uses cryo-EM to determine the structure of the TSCC complex, revealing its architecture and potential mechanisms of Rheb regulation.

This study identifies lncRNA-RMST as a SOX2 co-regulator that modulates miR-1251 expression, influencing cell proliferation and migration in Hirschsprung's disease.

The paper identifies an octopaminergic circuit that regulates glial potassium and water buffering, showing dual roles in maintaining and reducing glial buffering under different conditions.

This study shows that SARS-CoV-2 attached to salmon can remain infectious for over a week at 4°C, indicating a potential transmission risk in seafood markets.

This study shows that genome doubling in allopolyploids can recover transcriptional and splicing changes from hybridization, partially fixing heterosis and revealing new insights into transcriptome reprogramming mechanisms.

This study analyzes the genomic structure and adaptive potential of G. purpurascens, a landrace of G. hirsutum, to understand its biogeographic history and divergence from modern cultivars.

This paper develops a safe, effective, and scalable anthelmintic based on Bacillus thuringiensis Cry5B for treating human gastrointestinal nematodes.

The paper shows that differentiated epidermal cells regulate stem cell behavior through mechanical signals, affecting proliferation, fate, and migration.

This study distinguishes swarming from planktonic bacterial motion by confining bacteria in microwells, revealing distinct motion patterns in swarming and planktonic states.

This study reveals the transport mechanism of class-3 P4 ATPases by analyzing their structure and function, showing conserved lipid-flipping mechanisms and unique features.

This study infects human iPSC-derived cardiac cells with SARS-CoV-2 and identifies novel cytopathic features in COVID-19 patient hearts, including myofibrillar fragmentation and DNA loss in cardiomyocytes.

This study shows SARS-CoV-2 uses the SR-B1-mediated HDL uptake pathway alongside ACE2 for entry, and blocking this pathway inhibits infection.

This study identifies Bmp8a as a positive regulator of antiviral immunity, showing its role in enhancing type I IFN production and reducing viral load in zebrafish.

The paper analyzes SARS-CoV-2 genome sequences to study mutation patterns and evolutionary dynamics, identifying mutations that may enhance viral fitness and provide insights for vaccine development.

Virus-antibody coevolution in rhesus macaques recapitulates developmental features of human antibodies.

This study shows an inactivated SARS-CoV-2 vaccine induces neutralizing antibodies and CTL responses in rhesus macaques, effectively preventing viral replication and lung inflammation.

This paper identifies two potent DHODH inhibitors with broad-spectrum antiviral activity against RNA viruses, including SARS-CoV-2, and suggests their potential clinical use.

This paper develops a biomimetic HTM hydrogel model to study glaucoma pathology and test therapeutic interventions.

This study shows Rbx1 and Ube2m differentially regulate Treg cell homeostasis and function, with Rbx1 deletion causing severe inflammation and Ube2m deletion causing milder issues, suggesting therapeutic potential for targeting neddylation/CRLs in immune disorders.

This study investigates the micro- and macroevolution of Prevotella copri-containing lineage in primate guts, revealing co-evolution with humans, host jumping, and horizontal gene transfer.

The paper shows heroin cues induce two distinct astrocyte subpopulation plasticities that reduce heroin relapse in rats.

HiFi-SIM improves structured illumination microscopy image fidelity by reducing artifacts and enhancing axial resolution without requiring precise PSF calibration or parameter tuning.

This paper describes a catalase-based therapeutic for COVID-19 that reduces oxidative stress and cytokine production in human and animal models without toxicity.

This study identifies Aqp5 as a key factor in IPMN development using a novel mouse model, linking nuclear GSK-3β and oncogenic KRas to terminal duct cell expansion.