H. Li

This study tracks white matter changes in SIV-infected rhesus monkeys with and without cART, finding early alterations at 4 weeks and varying cART effects over time.

This study reveals how Yta7 ATPase disassembles nucleosomes by unfolding histone H3 through a rotary staircase mechanism involving its BRD and AAA+ modules.

The paper identifies Alr3614 as a repressor of type V-K CRISPR-associated transposase systems in Anabaena sp. PCC 7120 through genetic and structural analyses.

This study shows that engineering human stem cell-derived islets to secrete tolerogenic cytokines can prevent xeno-rejection without immunosuppression or encapsulation.

The paper identifies ATM and KEAP1 as targetable vulnerabilities in solid tumors through a CRISPR metabolic screen revealing their synthetic lethality.

This study shows that interfering with DicVg4 and DicVgR genes in Diaphorina citri reduces vitellogenin accumulation, prevents normal egg formation, and leads to abnormal eggs and nymphs.

The paper identifies energy waves as the mechanism for redistributing heme energy in myoglobin after photolysis, showing they are more efficient than diffusion-based processes.

This study analyzes methicillin-resistant M. caseolyticus isolates from retail meat and GenBank, revealing geographic lineage distribution, antimicrobial resistance, virulence factors, and morphological differences.

The paper shows that tumor stemness switch phenotype CSCs undergo bystander apoptosis when infected with BCG or Mtb, activating a niche defense mechanism with anti-tumor and anti-microbial effects.

This study examines how restricted feeding during gestation affects blood glucose levels and gut microbiota in sows across pregnancy and lactation stages.

This study compares the effects of immunomodulatory BT peptide and antibiotics on cecal microbiota in broilers challenged with Clostridium perfringens, finding differences in microbial composition and function.

The paper investigates how alternative 3' UTRs regulate gene expression in response to high salt stress in Spartina alterniflora, showing that 3' UTR lengthening enhances RNA stability and protein synthesis of stress-related genes.

This study shows miR155 inhibits osteogenesis and reduces bone mass by targeting S1PR1, suggesting miR155 inhibition could promote bone regeneration.

The paper shows that elevated ROS levels impair OXPHOS assembly via ferroptosis and mitochondrial unfolded protein response.

This study predicts water deer range expansion and dispersal routes in Northeast Asia using MaxEnt and circuitscape, identifying key habitats and potential conservation corridors.

This study develops two ERR agonists that improve heart failure by enhancing fatty acid metabolism and mitochondrial function in mice.

The paper investigates how gut microbiota contributes to cold-climate adaptation in two lizard species, finding species-specific differences in microbial composition and metabolic gene abundance.

The paper identifies Flaviviridae-derived endogenous viral elements in shrew genomes, revealing an ancient origin of pestiviruses and their potential role as natural reservoirs.

This study demonstrates that MYCN and BCL2 enhance interspecies chimerism with human pluripotent stem cells, enabling the generation of functional human blood progenitor cells in chimeric embryos.

This study characterizes the HERV-K (HML-8) group in the human genome, identifying 40 proviruses and 5 solo LTR elements and determining their integration time and genomic distribution.

This study reports the structure of the MCM8/9 helicase complex using cryo-EM, revealing its DNA unwinding mechanism through conformational changes and rotary motions.

The paper uses single-cell RNA sequencing to identify six distinct stromal cell populations in human bone marrow and their roles in hematopoiesis.

This study determines the cryo-EM structures of AAV9 and AAVPHP.eB in complex with their receptor AA VR, revealing molecular details of receptor recognition and explaining enhanced CNS transduction.

This study identifies Tnrc6a as a regulator of centriole amplification and multicilia formation through local translation of miRNA targets in airway epithelial cells.

This study identifies FAM84B amplification as a marker of poor prognosis in ESCC and shows it promotes cell proliferation by interacting with NPM1 to suppress CDKN2A.

The paper introduces a method to identify the one-dimensional reaction coordinate for protein dynamics, linking structure to function through a generalized work functional.

The paper identifies core bacterial taxa and mobile genetic elements associated with extracellular antibiotic resistance genes in water compartments.

This study investigates the substrate specificity of human SETD3, showing it can methylate histidine and its mimics, with histidine being the most efficient substrate.