H. Li

This study shows that phagocytic and neutralisation functions of anti-Spike antibodies persist in SARS-CoV-2 convalescents despite declining antibody titers, with improved antibody affinity correlating with maintained effector functions.

This study examines how nicotine and estrogen affect articular cartilage friction and PRG4 secretion in vitro, finding nicotine reduces friction and PRG4 while estrogen reverses these effects.

This paper develops a high-throughput GlyExo-Capture technique to isolate fucosylated extracellular vesicles and identifies a 4-miRNA signature for hepatocellular carcinoma detection.

This study constructs a single-cell transcriptome atlas of multiple myeloma patients stratified by R-ISS, identifies PC subsets and immunotargets, and links them to prognosis and EBV infection.

This study isolates salt-tolerant fungal endophytes from halophytic plants and shows they improve wheat growth and salt tolerance at the seedling stage.

This study identifies ANXA2 as a negative regulator of type I IFN production, which enhances virus replication by inhibiting antiviral signaling pathways.

This study identifies a resident state in influenza polymerase that enables smooth transitions between transcription and replication cycles through structural analysis.

This study shows that nucleobase clustering in RNA with repeat expansions leads to the formation and hollowing of RNA condensates, contributing to neurodegenerative disease mechanisms.

The paper introduces an AuSERP biochip to detect single extracellular vesicle RNA and protein biomarkers for predicting immunotherapy responses in NSCLC patients, showing higher sensitivity than traditional methods.

The paper examines bladder enlargement in nine rodent diabetes models, finding variable enlargement and weak glucose correlations.

This study elucidates how the Cdc48 ATPase complex unfolds and translocates polyubiquitinated protein substrates through cooperative binding with Ufd1/Npl4.

The paper investigates the role of parthenogenetic Asian longhorned ticks in spreading SFTSV, finding they contribute to rapid spread and long-range movement.

This study identifies peroxisome-derived H2O2 targets and shows their sulfenylation kinetics vary across compartments and protein families.

This study shows that combining dalpiciclib with pyrotinib is more effective than pyrotinib with tamoxifen in treating triple-positive breast cancer, with CALML5 as a potential biomarker.

This paper identifies chemical motifs for β-arrestin-biased D1R agonists through SAR studies of A-86929 analogs and small biaryl fragments.

This paper reveals the mechanism by which Rad24-RFC loads the 9-1-1 clamp onto DNA by inserting ssDNA from the top of an open ring, differing from RFC/PCNA loading.

This study shows that ECM stiffness and TGFβ2 regulate YAP/TAZ activity in HTM cells, contributing to glaucoma progression.

The paper identifies KCRs, light-gated potassium channels from a fungus-like protist, which are highly selective and fast-acting, showing potential for optogenetic control of potassium gradients in neurological and cardiac diseases.

This study shows that m6A modifications regulate intestinal immunity and rotavirus infection by modulating IRF7 and IFN expression through METTL3 in intestinal epithelial cells.

This study shows that suppressing Chl a catabolism in ryegrass reduces heat tolerance by disrupting photosystem stability, ROS balance, and chloroplast structure under moderate heat stress.

The paper identifies distinct extracellular tRNA-derived small RNA (tDR) fragmentation signatures associated with different stress responses and shows their potential as biomarkers in human disease.

This study shows that senescence promotes reprogramming through the SASP factor Amphiregulin, which enhances proliferation and MET via EGFR signaling, improving reprogramming efficiency.

This study identifies key traits enabling Schrenkiella parvula to maintain growth and reproductive success under salt stress.

This study shows L-citrulline reduces hypertension, improves placental function, and fetal growth in a rat model of preeclampsia.

This study isolates and characterizes alveolar type II cells using multi-omics and establishes a method for their organotypic culture.

This paper reports the structure and function of Pseudomonas aeruginosa CtpA, showing it forms an inactive hexamer that requires the spiral-shaped lipoprotein LbcA for activation and substrate delivery.

This study evaluates methods for creating gastrojejunostomy using magnetic compression and pyloric ligation in rabbits, finding that pyloric ligation provides better long-term patency than paclitaxel-loaded magnets.

The paper identifies a Jurassic fossil as an epiphytic macrolichen, suggesting macrolichen diversity predates the Cenozoic diversification of extant lineages.

This study engineers AAV vectors for acoustically targeted gene delivery, improving specificity and efficiency while reducing peripheral transduction.