H. Li

This study evaluates CRISPR/Cas9, CRISPR/LbCpf1, and base editors for targeted genome editing in grape, showing variable efficiencies and PAM specificity.

This study creates a human fetal cerebellar cell atlas to identify transitional progenitors linked to aggressive medulloblastoma subgroups and their oncogenic mechanisms.

The paper uses single-cell RNA-seq to analyze factors influencing CD4 T cell activation and identifies distinct functional states and differentiation patterns.

This study shows that bempedoic acid reduces cyst growth in ADPKD cells and mice, and combining it with tolvaptan enhances therapeutic effects.

This study shows that epithelial monolayers recover structural integrity after apoptosis-induced defects through enhanced cell spreading, migration, and traction forces.

This study shows that hypomorphic HD-PTP/PTPN23 mice develop lipodystrophy and reduced adipogenesis, indicating HD-PTP's role in insulin signaling and fat accumulation.

The paper demonstrates that swim bladder resonance enhances hearing in crucian carp through auditory evoked potentials, Micro-CT, and numerical simulations.

This study investigates the effects of cell-free fat extract (CEFFE) on osteoclastogenesis, showing its ability to reduce bone loss and inhibit osteoclast formation through antioxidant and calcium signaling modulation.

The paper develops a brain age prediction model using multiscale functional connectivity from rsfMRI data of 4,259 individuals, showing that multiscale measures improve prediction and that brain age gaps correlate with cognitive and clinical measures.

The paper engineers nanobody interfaces to improve crystal reliability and diversity, resulting in better diffraction and multiple polymorphs.

This study presents the cryoEM structure of LCMV surface glycoprotein and shows that the antibody M28 neutralizes the virus by stabilizing its prefusion state, offering a therapeutic candidate for LCMV infection.

This study shows that osteocyte ablation in mice leads to senescence-associated changes in bone and bone marrow lineages, causing sarcopenia, osteoporosis, and shortened lifespan.

This study identifies NCgl0254 and NCgl0255 as novel O_SCPLOWLC_SCPLOW-serine exporters in C. glutamicum and shows that all four exporters (ThrE, SerE, NCgl0254, NCgl0255) are interdependent in O_SCPLOWLC_SCPLOW-serine export, with SerE being the major contributor.

The paper identifies TMEM164 as an acyltransferase that produces PUFA ether phospholipids, essential for ferroptosis, and shows its absence reduces these lipids and protects cells from ferroptosis.

This study identifies ZmEREB57 as a maize AP2/ERF transcription factor that enhances salt stress tolerance by regulating OPDA and JA signaling through two distinct pathways.

This study observes and attributes intermittent bioluminescence blinking in native bacteria to stochastic gating of Na+/H+ antiporters, revealing their dynamic behavior in living cells.

This study shows that the wheat pathogen Fusarium graminearum can acquire nitrogen-fixing facultative endohyphal bacteria from soil, enhancing its pathogenicity.

The paper identifies a genetic locus associated with root bending in response to salinity, showing that extensin arabinosylation is required for directional root responses to salt.

This study presents the cryo-EM structure of Cas7-11, revealing its mechanism for processing CRISPR RNA and cleaving target RNA.

This study investigates multidimensional plasticity in Ciona savignyi under salinity stress, showing gene expression, alternative splicing, and polyadenylation each play distinct roles in adaptation.

This paper introduces PRESIR, a method to correct motion-related decorrelation noise in FD-OCT, improving motion detection sensitivity and accuracy.

This study identifies two switchable Rac1 pools in Drosophila border cells that integrate direction and coordination during collective migration.

This study shows that inhibiting nuclear export disrupts epithelial-mesenchymal states and affects collective cell migration in healthy epithelia.

This study identifies differentially expressed genes and pathways in Kluyveromyces marxianus under acetic acid stress during high-temperature ethanol fermentation, revealing effects on protein metabolism and ethanol production.

The paper introduces a microbial risk score (MRS) framework to aggregate microbiome data into a predictive score for disease risk, validated across multiple cohorts.

This study identifies TRIM21 as a regulator of PKR-mediated protein translation by modulating PP1 ubiquitination and eIF2 dephosphorylation, revealing its role in antiviral defense and potential therapeutic applications.

This study shows that YAP/TAZ signaling is involved in TGFβ2-induced dysfunction of Schlemm's canal cells and that inhibiting YAP/TAZ can reduce this dysfunction.

This study examines how aridity affects the distribution and community assembly of cyanobacterial morphotypes in drylands, finding that stochastic processes dominate but aridity influences the balance between determinism and stochasticity.

This study uses native mass spectrometry and molecular dynamics to show how intrinsically disordered CTDs in Hfq form a network that integrates RNA contacts and stabilizes the hexamer.

This paper describes the scalable purification of Bt Cry5B crystals and demonstrates their potent bioactivity against nematodes in vitro and in vivo.