H. Liu

This study uses fMRI to show that amblyopia causes layer-specific changes in subcortical visual pathways, with reduced feedforward signals in the geniculostriate pathway and altered feedback signals in the retinotectal pathway.

The paper identifies binary and ternary protein interactions among SARS-CoV-2 replication/transcription complex components using a novel compartmentalization-based screening method.

The paper identifies two transcription factors, RlmA and Ace1, critical for Aspergillus fumigatus virulence by analyzing gene expression during lung infection in mice.

This paper develops a microengineered lung organ chip model to study SARS-CoV-2-induced lung injury and immune responses, revealing distinct cellular responses and the role of immune cells in inflammation.

The paper identifies celastrol as a novel HIV-1 latency reversal agent through an image-based screen of a natural compound library.

The paper systematically investigates dynamic mechanical stimulation protocols for mesenchymal stromal cells to optimize matrix production and myofibrogenesis in 3D hydrogels.

The paper shows that ACE2-expressing exosomes in plasma block SARS-CoV-2 infection by competing with cellular ACE2, offering a new innate antiviral mechanism.

This study shows that disrupting FGF2 enhances thermogenesis in brown and beige fat, reducing obesity and hepatic steatosis in mice.

This study shows that Top1 inhibition with Topotecan reduces SARS-CoV-2-induced inflammation and mortality in animal models.

The paper identifies imprinted genes in flax endosperm and shows their role in intraspecific variation and domestication.

This study shows that deleting Letmd1 in mice causes mitochondrial dysfunction in brown adipose tissue, leading to thermogenesis disruption and metabolic disorders.

The paper analyzes public data to show that PDCD1 and CD274 expression in T cells and macrophages correlates with COVID-19 severity.

This study investigates how a dominant-negative SOX18 mutant disrupts transcription factor activity by interfering with chromatin-binding dynamics and recruiting the wild-type interactome.

The paper identifies a CD127-expressing monocyte subset, M127, associated with anti-inflammatory properties in inflammatory diseases and correlates its expansion with milder COVID-19 outcomes.

The paper identifies potent SARS-CoV-2 neutralizing antibodies from a pre-pandemic human antibody library, showing high somatic hypermutation and specific binding to the spike protein.

This study shows that cannabidiol (CBD) reduces pulmonary arterial hypertension by improving mitochondrial function and reducing oxidative stress in vascular smooth muscle cells.

This study uses directed evolution to identify SH2 domain variants with enhanced binding to phosphotyrosine peptides, revealing differences in cross-reactivity with sulfotyrosine.

This study identifies the transferrin receptor (TfR) as an additional receptor for SARS-CoV-2 entry, showing that TfR-mediated infection can occur independently of ACE2 and that targeting TfR has anti-viral effects.

This study identifies SARS-CoV-2 papain-like protease (PLpro) as a novel substrate of ULK1, demonstrating its role in disrupting host autophagy to promote viral replication.

This study identifies a viral protein translation mechanism involving mitochondrial machinery and highlights mitochondria as a target for antiviral drug development.

The paper constructs and validates a prognostic signature for prostate cancer using ferroptosis-related genes, showing its association with clinical outcomes and therapeutic response.

This study uses respiratory tract explants from marine mammals and rhesus macaques to compare influenza A virus infection kinetics across species.

This study shows that prior exposure to one Sarbecovirus strain biases antibody response to a subsequent, antigenically distinct strain, suggesting antigenic imprinting affects immunity to SARS-CoV-2.

This paper identifies potent SARS-CoV-2 main protease inhibitors using accelerated free energy perturbation-based virtual screening of existing drugs, finding 15 inhibitors from 25 predicted drugs.

This study examines how a controlled closed environment affects human saliva microbiota and cytokines, finding stable microbial communities and reduced inflammatory markers.

This study shows heat stress inhibits meiotic recombination in Arabidopsis by reducing DSB formation and homolog synapsis, affecting chromosome axis stability and recombinase levels.

The paper identifies proximal tubule cell state and metabolism as coupled by nuclear receptors in kidney disease using single-cell RNA-sequencing.

This study shows that combining free ammonia pretreatment with anaerobic digestion reduces antibiotic resistance gene abundances in sludge.

This study shows that Eng1 and Ywp1 in C. albicans reduce Dectin-1 binding by masking β-glucans, thereby decreasing immune recognition and virulence.

This paper introduces a cell-based assay to identify coronavirus 3CL protease inhibitors without live virus, demonstrating its effectiveness through compound screening and structure-activity profiling.