H. Yu

This paper uses single-cell RNA sequencing to characterize neutrophil heterogeneity and maturation during homeostasis and bacterial infection, revealing distinct subsets and their functional transitions.

This study determines the cryo-EM structure of RyR1 and uses simulations to analyze cation hydration and conduction mechanisms in the receptor.

This paper engineers transketolase to accept novel donor and acceptor substrates, improving catalytic efficiency and stereoselectivity for industrial applications.

This study evaluates immune responses in mice to multi-epitope DNA and protein vaccines against CCHFV, finding that DNA prime-protein boost strategy enhances both cellular and humoral immunity.

The paper presents a comprehensive phosphoproteomic dataset for budding yeast, identifies cell cycle-regulated phosphorylation events, and shows phosphorylation disrupts protein-protein interactions.

This study reveals the Ca2+ permeation mechanism through RyR1 using molecular dynamics simulations, showing a one-at-a-time hydrated ion translocation pattern.

This study identifies mutant p53's role in promoting clonal hematopoiesis by modulating the EZH2-mediated epigenetic pathway.

This study shows that formaldehyde inhibits osteoblast proliferation and migration via the FoxO1 signaling pathway in mouse cells.

This study presents two structures of SETD3 bound to β-actin peptides, revealing sequence-specific recognition and methylation mechanism.

This study uses genome-wide resequencing of wheat landraces and cultivars to trace the genetic diversity and breeding history of bread wheat in China.

The paper shows that a soybean PBS1 decoy protein with a SMV NIa protease cleavage site triggers cell death and inhibits SMV spread, suggesting decoy engineering can be used in soybean and other crops.

The paper shows bile canaliculi contract by releasing calcium into hepatocytes via mechanosensitive channels, driven by bile pressure and regulated by Piezo-1.

This study shows that mitotic regulators and the SHP2-MAPK pathway promote insulin receptor endocytosis and feedback regulation of insulin signaling, improving insulin sensitivity when feedback is blocked.

This study compares 6-month angiographic and 2-year clinical outcomes between long and short chronic total occlusion (CTO) lesions after successful DES PCI, finding higher repeat PCI rates in long CTO lesions.

This study shows that sublancin enhances macrophage function and protects mice from MRSA infection by activating innate immunity and improving T cell responses.

The paper introduces a label-free optical imaging method to measure sub-nanometer mechanical motion during action potentials in single mammalian neurons, finding amplitude variations across neurons and regions.

This study shows type 2 diabetes increases centrosome amplification in PBMCs through AKT-ROS-dependent activation of ROCK1 and 14-3-3σ.