H. Yu

The paper uses genomic data to classify the Chinese mountain cat as a wildcat subspecies and finds no evidence of its role in domestic cat domestication in East Asia.

This study investigates N-glycosylation sites and glycan-binding ability of SARS-CoV-2 S-protein through phylogenetic analysis, structural comparison, docking analysis, and molecular dynamics simulation.

This study shows that lipidation of the Salmonella effector GtgE is essential for its membrane targeting and Rab32 inactivation, enabling Salmonella survival in macrophages.

The paper shows tobacco carcinogens increase ACE2 mRNA but reduce ACE2 protein levels via Skp2-mediated ubiquitination, decreasing SARS-CoV-2 infection in lung cells.

This study determines the cryo-EM structure of the yeast TRAPPIII complex bound to Rab1/Ypt1, revealing that Trs85 anchors the complex to membranes via an amphipathic helix to activate Rab1.

This study identifies 129 loci associated with 27 yield-related traits in tomato, explaining 8.8% of phenotypic variance, and highlights a candidate gene involved in leaf stomata formation and drought resistance.

PhenoImage is an open-source GUI tool for analyzing high-throughput plant phenotyping images, designed for users without programming skills.

This study compares the antimicrobial activity of bacitracin-soaked sutures to triclosan-coated sutures and unsoaked controls against Staphylococcus aureus and MRSA.

This study develops a virus-free live-cell visualization system for SARS-CoV-2 entry using a fluorescent spike trimer probe, enabling analysis of neutralizing antibodies and inhibitors.

The paper examines ACE2 expression on immune cells and finds that activated type 1 macrophages (M1) have high ACE2 expression, suggesting they may be targeted by SARS-CoV-2.

SeedExtractor is an open-source GUI tool for rapid and accurate seed size and color measurement across plant species, validated on rice with genome-wide association analysis.

The paper examines how wild emmer introgressions affect root-to-shoot growth dynamics under water stress in wheat, identifying a line with high plasticity and candidate genes for stress adaptation.

This study shows that loss of Aldob activates Akt, promoting hepatocellular carcinoma by destabilizing the Aldob/Akt/PP2A complex, and identifies SMAP as a potential therapeutic agent.

This study identifies the TRNVF motif as responsible for PI5P4Kβ's GTP binding and extended specificity to ITP and XTP, showing how its GTP preference allows it to function as a GTP sensor despite low cellular concentrations of ITP and XTP.

This study creates a single-cell transcriptome atlas of a non-human primate to explore SARS-CoV-2 targets and immune responses, identifying potential therapeutic targets and mechanisms linking IL6 to viral entry.

The paper shows acetylation of TDP-43 drives its phase separation into intranuclear spherical annuli with liquid properties, regulated by HSP70 chaperone activity and proteasome function.

The paper develops CAR-expressing iPSC-derived macrophage cells with antigen-dependent anti-cancer functions effective against both liquid and solid tumors.

This study shows that rhesus macaques infected with SARS-CoV-2 are protected from reinfection during early recovery, likely due to enhanced neutralizing antibodies.

This study shows that SARS-CoV-2 can cause mild COVID-19 in rhesus macaques through conjunctival inoculation, with distinct viral dispersion patterns compared to intratracheal inoculation.

This study infects hACE2 transgenic mice with SARS-CoV-2 and observes pathogenic effects, confirming Koch's postulates and establishing a model for vaccine and therapeutic development.

This study shows that NE-low SCLC tumors have more immune cell infiltration and higher expression of IDO and PVR compared to NE-high tumors, suggesting these as potential immunotherapy targets.

The paper investigates the origin and evolution of A-to-I RNA editing in metazoans, finding it emerged in the common ancestor and is nonadaptive in most regions except for specific taxa.

The paper introduces PI-Plat, a 3D imaging method to estimate rice inflorescence growth dynamics, showing voxel count correlates with seed number and maturation rate.

The paper uses a synthetic system to study maize auxin signaling, showing that the circuit is sensitive and functionally similar to Arabidopsis.

This study shows HIV-1 Vpr suppresses IRF7 and IFN-I expression in pDCs by degrading TET2, thereby enhancing HIV-1 replication.

This study examines the relationship between serum kisspeptin levels and male fertility, finding a strong correlation with sperm concentration and a potential threshold to distinguish obstructive from non-obstructive azoospermia.

This study examines how modified sialic acids in mucus and erythrocytes affect influenza A virus HA and NA functions, finding that these modifications inhibit viral binding and cleavage.

This study identifies determinants of sialoglycan-binding selectivity in Siglec-like adhesins and creates engineered binding proteins for specific glycan recognition.