J. Chen

The paper introduces SUMIC, a fast and simple method for whole-organ and large tissue 3D imaging, revealing age-related expansion of lymphatic vessels in endocrine tissues.

This study examines how breast cancer tumors evolve during early stage treatment with combination CDK and endocrine inhibitors, finding convergent resistance pathways and increased subclonal diversity with combination therapy.

This study shows Ythdc1, an m6A reader, regulates LINE1 scaffold function in mouse ESCs, affecting self-renewal and differentiation through chromatin interactions.

This paper develops a non-viral method for efficient T cell genome editing using modified plasmids, achieving CAR-T cell functionality comparable to AAV-based methods.

This study introduces a multi-enzyme directed evolution model to improve screening throughput and efficiency, revealing convergent evolution in two cytochrome P450 enzymes with distinct active sites achieving similar functions.

This study shows that the tomato NLR Sw-5b acts in both cytoplasm and nucleus to provide full resistance against tospovirus by blocking different infection stages.

This study identifies exosomal miR-224's role in maintaining hemolymph microbiota homeostasis during bacterial infection in mud crabs by modulating immune signaling pathways.

The paper introduces the Allen Cell and Structure Segmenter, an open-source toolkit for 3D segmentation of intracellular structures in fluorescence microscopy images, achieving high accuracy through classic and deep learning workflows.

The paper establishes quantitative rules for the locations, amounts, and variation of 25 cellular structures in human iPSCs using high-resolution imaging and analysis.

This study uses atomistic simulations to investigate G4-hemin interactions, revealing dynamic binding mechanisms and suggesting hemin's role in G4 folding.

This study maps the conformational space of α-synuclein monomer using simulations and experimental validations, revealing stable conformations with slow interconversion times.

This study identifies two stem-like gastric cancer subpopulations with distinct chemoresistance and survival outcomes using scRNA-seq and organoid models.

The paper identifies small-molecule inhibitors of the SARS-CoV-2 spike-ACE2 interaction, showing they block viral entry with low micromolar activity.

This study uses resonance Raman spectroscopy to identify bacterial strains and detect live/dead bacteria by analyzing carotenoid spectra under UV radiation.

The paper identifies OsMKK1 as a direct target of OsDMI3 and shows that OsDMI3-mediated phosphorylation of OsMKK1 is crucial for ABA signaling and stress responses.

This paper identifies a mammalian-unique eIF4E2-GSK3β pathway that prevents senescence and protects against hypoxia by maintaining p53 phosphorylation.

This study identifies a viral protein translation mechanism involving mitochondrial machinery and highlights mitochondria as a target for antiviral drug development.

This study uses TRACE-seq to analyze single throat swabs, integrating SARS-CoV-2 genome, microbiome, antibiotic resistance, and host response data.

This study identifies synthetic lethality between ENDOD1 and TP53, showing that their combined loss causes DNA damage and cell death, suggesting ENDOD1 as a cancer therapeutic target.

The paper evaluates methods to enhance skin permeation of decapeptide-12, finding that microneedle patches with palmitate-modified peptides provide the best delivery.

This study shows that SARS-CoV-2 proteins and anti-COVID-19 drugs can reactivate KSHV, increasing cancer risk in infected patients.

This study examines age and sex effects on resting-state EEG and fMRI frequency and amplitude in healthy adults, finding age-related changes in power and frequency but negligible sex effects.

This study compares the temporal transcriptomes of two Verticillium dahliae strains to identify pectin degradation genes linked to pathogenicity in Upland cotton.

This study investigates the relationship between respiratory-volume variability and EEG signals across brain regions, finding two regimes of EEG-RVT association with implications for cognitive processes.

This study uses single-cell RNA-seq to analyze stromal vascular fraction cells in cancer-related lymphedema, identifying lineage-specific changes and potential therapeutic targets.

This study profiles protein crotonylation in different mouse pluripotent states, identifying 3628 sites and showing that crotonyl-CoA promotes proteasome activity and delays differentiation.

This study identifies ceftazidime as a drug that inhibits SARS-CoV-2 infection by blocking the spike protein-ACE2 interaction in vitro, with an IC50 below therapeutic blood concentrations.

This study shows NLRC5 upregulates MHC-I in transmissible cancers, making MHC-I a target for anti-tumor immunity and informing immunotherapy strategies.

The paper investigates how pharmacological and genetic manipulations of Ca2+ signaling affect auxin-regulated PIN trafficking, finding contrasting results between exogenous Ca2+ manipulations and genetic mutants.

This study uses multi-region single-cell sequencing to map the spatial and cellular architecture of early-stage lung adenocarcinoma, revealing geospatial lineage evolution and potential therapeutic targets.