J. Chen

This study shows that ZFP36L1 deficiency protects mice from alcohol-induced liver steatosis and inflammation by stabilizing Fgf21 mRNA.

The paper uses cryo-EM and AlphaFold2 to determine the structure of SARS-CoV-2 Nsp2, revealing its zinc-binding site and potential interactions with host proteins.

This paper demonstrates the use of induced pluripotent stem cells to create an isogenic system for studying genetic influences on cell-cell interactions in type 1 diabetes.

This study tests a T cell vaccine in HLA-A*02:01 mice to assess its immunogenicity against SARS-CoV-2 variants.

This paper identifies LY-CoV1404, a potent SARS-CoV-2 neutralizing antibody effective against multiple variants, including Omicron and Delta, due to its conserved epitope and resistance to common mutations.

The paper shows that SAC gene expression in fission yeast is fine-tuned through codon usage and mRNA/protein half-life strategies to ensure proper checkpoint function.

This paper introduces a hierarchical Bayesian calibration method for dynamic vegetation models, showing it improves prediction accuracy by accounting for site-to-site parameter variability.

The paper transplants mouse high fat diet microbiota into zebrafish larvae to identify microbial factors that accelerate hyperlipidaemia via MyD88 signaling.

This study shows YTHDF2, an m6A reader, enhances NK cell anti-tumor and anti-viral responses by regulating homeostasis, maturation, and effector function through STAT5 feedback and Tardbp interactions.

The paper defines the role of wild-type and patient-specific TP53 mutations in ERMS using zebrafish models, showing tp53 loss increases tumor initiation and identifying mutation-specific effects on tumor development.

This study identifies SINEs as inhibitors of CRISPR-Cas9 activity by blocking Cas9 mRNA nuclear export, enhancing genome and base editing specificity in human cells.

This study shows that rat mesenchymal stem cells express Ang1 and Ang2, which are upregulated during osteogenesis in vitro.

This study identifies high-frequency SARS-CoV-2 mutations that may compromise multiple monoclonal antibody therapies in clinical trials using a topology-based deep learning approach.

This study identifies a young gene in Arabidopsis thaliana that shows strong positive selection and contributes to morphological trait divergence through neofunctionalization.

This paper shows that SARS-CoV-2 RdRp undergoes backtracking, which may aid proofreading and antiviral resistance.

This study compares Brachypodium and Arabidopsis embryo development, finding conserved and divergent transcriptional programs with widespread heterochronic gene expression.

This paper introduces label-retention expansion microscopy (LR-ExM) to prevent fluorescence signal loss and enable high-efficiency labeling, achieving molecular resolution in visualizing clathrin-coated pits.

This study identifies that specific PIP2 binding to TMEM16A promotes calcium activation by enabling spontaneous opening of the permeation pathway in the Ca2+-bound state.

This study shows that lysosomes are regulated by TFEB and MYC to balance catabolic and anabolic processes in hematopoietic stem cells, influencing their fate and activation.

This study shows that NOX2-derived reactive oxygen species are essential for CD8+ T cell effector function by promoting T-bet expression and mTOR complex 1 activation.

The paper reports the cryo-EM structure of an amyloid fibril formed by the E196K mutation in human PrP, revealing a distinct conformation compared to wild-type PrP fibrils.

This study shows that RIPK3 phosphorylation at S165/T166 switches its function from necroptosis to apoptosis, driving corpus luteum regression via PGF2-induced apoptosis.

The paper introduces a rapid antimicrobial efficacy profiling method using clinical urine specimens, achieving 100% agreement with conventional AST methods for specific antibiotics.

This study identifies ESR1 mutations as drivers of breast cancer metastasis by altering cell adhesion and migration through genomic and transcriptomic reprogramming.

This paper develops a PET probe for subtype-selective V1A receptor imaging in peripheral organs, showing high affinity and selectivity for V1A over other vasopressin receptors.

The paper identifies immune hubs in colorectal cancer by analyzing transcriptional and spatial patterns in MMRd and MMRp tumors.

This study investigates TAK1's role in retinal neovascularization and shows that inhibiting TAK1 reduces aberrant angiogenesis in a rat model.

This study investigates the role of STARCH SYNTHASE 4 (SS4) in wheat endosperm starch granule initiation, finding that SS4 deficiency causes compound granule formation and reduced starch content.

The paper identifies two small proteins, MHA1 and MHA1L, that modulate ACD6 activity in Arabidopsis thaliana, affecting growth and defense trade-offs through calcium influx regulation.

This study identifies SNAI2 as a repressor of BIM, protecting rhabdomyosarcoma from ionizing radiation through a P53-independent mechanism.