J. Chen

This study shows that miR-200 deficiency in lung cancer cells promotes metastasis by activating cancer-associated fibroblasts through Notch signaling.

The paper presents cryo-EM structures of the SARS-CoV-2 holo-RdRp complex with nsp13 helicase, revealing interactions and a new therapeutic target.

The paper tests how a generalist natural enemy affects coexistence of competing insect species and finds that parasitism impacts coexistence through fitness differences, not niche differences, with no overall trade-off between reproductive rate and susceptibility.

The study evaluates anti-SARS-CoV-2 antibody and neutralizing titer profiles in convalescent plasma samples to determine the optimal donation window for immunotherapy.

The paper uses cryo-EM to visualize Mfd interacting with stalled RNA polymerase complexes, revealing its mechanism for initiating transcription-coupled repair.

This study shows chronic palmitic acid exposure reduces AKT in beta-cells via mTOR activation, leading to cell cycle inhibition and T2D risk.

The paper examines gut microbial communities in phenotypically divergent populations of Chilo suppressalis, finding variations linked to diet and gut compartments.

This study shows that human lung organoids can model SARS-CoV-2 infection and drug response, revealing virus targets and effective antiviral treatment.

This study shows PKD1 phosphorylates CBX8, disrupting PRC1 complex binding and promoting cell senescence by derepressing p16.

The paper designs de novo ACE2 protein decoys to neutralize SARS-CoV-2 by blocking viral entry, showing high affinity and potent in vitro inhibition.

The paper introduces a method for preparing cryoEM grids to study short-lived molecular states by rapidly dispensing sample drops and vitrifying them.

The paper sequenced genomes of Pneumocystis species from different mammals to study host specificity and evolutionary adaptations, revealing insights into the emergence of the human pathogen P. jirovecii.

This study examines the relationship between neuroendocrine and immune gene expression in SCLC, finding that variant SCLC tumors regain immune gene expression and exhibit higher tumor-immune interactions.

This study investigates how substrate recognition modulates strigolactone receptor selectivity in witchweed using molecular dynamics simulations and structural analysis.

This study identifies parasite variant surface antigens that help Plasmodium falciparum evade immune clearance in vivo using a humanized mouse model.

The paper identifies five ABCB transporters that regulate lateral root spacing in Arabidopsis by modulating auxin oscillation amplitude in outer root tissues.

This study shows that metformin chlorination byproducts are toxic to nematodes, human cells, and mice, and identifies boiling and activated carbon as effective removal methods.

This paper describes a catalase-based therapeutic for COVID-19 that reduces oxidative stress and cytokine production in human and animal models without toxicity.

This study analyzes S:A ratios across species to understand dosage compensation mechanisms in sex chromosomes, finding clade-specific patterns and supporting the sex chromosome insensitivity hypothesis.

The paper shows that disrupting cell cycle checkpoints can restore DNA damage-induced inflammation and anti-tumor immune responses in cancer cells.

The paper identifies 54% of human PH domain-containing proteins as having PIP binding affinity, using single-molecule pulldown assays and a recursive-learning algorithm.

This study shows the D614G mutation in SARS-CoV-2 spike protein increases viral infectivity and is more susceptible to elastase cleavage, with minimal impact on neutralizing antibody efficacy.

This study shows that combining controlled-release urea with 300 kg ha-1 potassium chloride improves soil fertility, plant growth, and yield of Italian ryegrass.

This study shows that increasing crop diversity enhances biomass but reduces seed yield due to lower reproductive effort in mixtures compared to monocultures.

This study compares CRISPR/Cas endonucleases for in vivo retinal gene editing and finds SpCas9 delivered via AAV7m8 achieves the highest knockout efficacy.

This study finds a strong correlation between anti-RBD and anti-ECD IgG titers and in vitro virus neutralization titers in convalescent plasma, suggesting these titers can serve as surrogates for neutralizing activity.

The paper shows iron supplementation eliminates antagonistic interactions between root-associated bacteria by revealing iron limitation drives these interactions.

This study identifies LILRB3 as a myeloid checkpoint receptor that suppresses immune responses through agonistic monoclonal antibodies, showing immunosuppressive effects in vitro and in humanized mice.

This study evaluates how the radiated brain microenvironment affects the growth of nine human glioblastoma cell lines, finding that some tumors grow faster while others grow slower in this environment.

This study identifies the tumor cell proteome of pancreatic cancer in vivo using BONCAT and DIA-MS, distinguishing it from non-tumor cells in the tumor microenvironment.