Author

P. A. Darrah

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:rat· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Organism:non-human primate· 2 Approach:statistical model· 2

Frequent Co-Authors

M. Roederer· 5 shared J. L. Flynn· 4 shared E. B. Irvine· 3 shared R. A. Seder· 3 shared G. Alter· 2 shared M. Kamath· 2 shared R. Seder· 2 shared S. M. Fortune· 2 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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5 shared papersImmunology

M. Roederer

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Author profile →

5 papers

Recent·Most cited

Antibody-mediated depletion of select T cell subsets in blood and tissue of nonhuman primates

M. S. Sutton, A. N. Bucsan, C. C. Lehman, M. Kamath, S. Pokkali, D. M. Magnani, R. Seder, P. A. Darrah, M. Roederer

The paper evaluates the depletion of T cell subsets in nonhuman primates using monoclonal antibodies, finding substantial depletion in blood and tissue with residual cells often remaining in tissue.

bioRxiv · Dec 22, 2023 · PreprintImmunology

Humoral correlates of protection against Mycobacterium tuberculosis following intravenous Bacille Calmette-Guerin vaccination in rhesus macaques

E. B. Irvine, P. A. Darrah, S. Wang, C. Wang, R. McNamara, M. Roederer, R. A. Seder, D. A. Lauffenburger, J. L. Flynn, S. M. Fortune, G. Alter

This study identifies humoral immune responses as correlates of protection against Mtb following IV BCG vaccination in rhesus macaques.

bioRxiv · Jul 31, 2023 · PreprintImmunology

Protective intravenous BCG vaccination induces enhanced immune signaling in the airways

J. M. Peters, E. B. Irvine, J. M. Rosenberg, M. H. Wadsworth, T. K. Hughes, M. Sutton, S. K. Nyquist, J. D. Bromley, R. Mondal, M. Roederer, R. Seder, P. A. Darrah, J. L. Flynn, A. K. Shalek, S. M. Fortune, B. D. Bryson

This study shows that high-dose IV BCG vaccination in rhesus macaques enhances airway immune signaling and cellular responses, improving protection against Mtb.

bioRxiv · Jul 16, 2023 · PreprintImmunology

Blood Transcriptional Correlates of BCG-Induced Protection Against Tuberculosis in Rhesus Macaques

Y. E. Liu, P. A. Darrah, J. J. Zeppa, M. Kamath, F. Laboune, D. C. Doueck, P. Maiello, M. Roederer, J. L. Flynn, R. A. Seder, P. Khatri

The paper identifies blood transcriptional signatures from BCG-vaccinated rhesus macaques that correlate with protection against tuberculosis.

bioRxiv · Nov 14, 2022Immunology

Robust IgM responses following vaccination are associated with prevention of Mycobacterium tuberculosis infection in macaques

E. B. Irvine, A. O'Neil, P. A. Darrah, S. Shin, A. Choudhary, W. Li, W. Honnen, S. Mehra, D. Kaushal, H. P. Gideon, J. L. Flynn, M. Roederer, R. A. Seder, A. Pinter, S. Fortune, G. Alter

This study shows that IV BCG vaccination in macaques induces strong IgM responses associated with reduced Mtb bacterial burden and protection.

Nature Immunology · Nov 22, 2021Peer-reviewedImmunology